retinal progenitor cell
Reconstruction of rat retinal progenitor cell lineages in vitro reveals a surprising degree of stochasticity in cell fate decisions
... and cell type ...rat retinal progenitor cell (RPC) undergoing a P/D division (t20:30) and a terminal D/D division (t58:11) giving rise to a three-cell clone composed of an amacrine ...
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Long-term safety of human retinal progenitor cell transplantation in retinitis pigmentosa patients
... of retinal degeneration compared to the earlier stage of the disease process in the RCS ...donor cell survival ...s retinal function may have a direct impact on postoperative recovery and should be ...
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Defining retinal progenitor cell competence in Xenopus laevis by clonal analysis
... for cell fate determination in the developing vertebrate ...individual retinal progenitor cells (RPCs) generate ...of retinal cells is formed in 2 ...a cell cycle marker, ...
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VEGF activates divergent intracellular signaling components to regulate retinal progenitor cell proliferation and neuronal differentiation
... influence progenitor cell fate ...uncommitted progenitor cells interpret and integrate signals is not well ...on progenitor cells to influence cell proliferation and ...increases ...
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Retinal horizontal cells: challenging paradigms of neural development and cancer biology
... common retinal progenitor cell population (Turner et ...these retinal progenitor cells translocate to the future outer limiting membrane (OLM) of the developing retina (the ventricular ...
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The LGN protein promotes planar proliferative divisions in the neocortex but apicobasal asymmetric terminal divisions in the retina
... transverse retinal sections with Lgn (A-C) and Ags3 (D-F) antisense ...RPL, retinal progenitor cell layer; GCL, ganglion cell ...the retinal pigment epithelium, which remains ...
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Enhanced generation of retinal progenitor cells from human retinal pigment epithelial cells induced by amniotic fluid
... immortalized cell lines [16-19]. However, of all stem cells, retinal derived progenitor cells may be a more efficient treatment for vis- ual impairment ...of retinal pigment epithelium (RPE) ...
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The identification of effectors of retinal cell fate determination through single cell transcriptomics
... each progenitor cell to its final fate as a specialized neuron is important for multiple ...uncommitted progenitor cell to a fully functioning neuron may be shared among developing central ...
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Characterizing and influencing differentiation of Retinal Progenitor Cells
... specified retinal cell types are generated from a common precursor, the retinal progenitor cell, which gives rise to all retinal cell types (Levine and Green, ...
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Hairy1 acts as a node downstream of Wnt signaling to maintain retinal stem cell like progenitor cells in the chick ciliary marginal zone
... of retinal progenitor cell differentiation (Kubo et ...keep progenitor cells undifferentiated in a wide variety of tissues (reviewed by Davis and Turner, 2001; Fisher and Caudy, 1998; Kageyama ...
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Loss of XBP1 accelerates age-related decline in retinal function and neurodegeneration
... of cell proliferation and differentiation after devel- ...of retinal cells at just two months of age ...in retinal metabolism is likely behind some age-related deterioration in retinal ...
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Floor plate derived sonic hedgehog regulates glial and ependymal cell fates in the developing spinal cord
... and cell fate specification are directed by signaling centers that provide spatial information through the localized production and secretion of protein ...of cell types along the transverse/dorsoventral ...
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Control of Caenorhabditis elegans germ-line stem-cell cycling speed meets requirements of design to minimize mutation accumulation
... a progenitor cell (blue), at the cost of a substantial increase in average pedigree ...differentiated cell production without incurring a large pedigree-depth ...stem cell located at the ...
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Cell therapy using retinal progenitor cells shows therapeutic effect in a chemically induced rotenone mouse model of Leber hereditary optic neuropathy
... from retinal ganglion cell pathology, which leads to optic nerve degeneration and ...embryonic retinal cells do not integrate into the ganglion cell layer (GCL), unlike similarly obtained ...
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The early retinal progenitor expressed gene Sox11 regulates the timing of the differentiation of retinal cells
... of retinal ganglion cells, began to be expressed; some Brn3b-positive cells expressed Sox11 ...using retinal sections at various stages as ...various retinal markers at indicated developmental ...
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Genetic chimeras reveal the autonomy requirements for Vsx2 in embryonic retinal progenitor cells
... nascent retinal neurons that induces neighboring RPCs to ...premature retinal neurogenesis and influence progression of the neurogenic wave in fish and chick ...to-peripheral retinal positions within ...
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Search for the preadipocyte progenitor cell
... Neutrophil infiltration into the lung is considered a crucial step in the patho- genesis of acute lung injury, yet data on the underlying mechanisms have been ambiguous: although selectin-mediated leukocyte rolling is ...
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Distinct roles of neuroepithelial like and radial glia like progenitor cells in cerebellar regeneration
... few cell types of distinct ...Purkinje cell layer (PL) and granule cell layer ...all cell layers, is unilaterally removed (red ...stem cell niche is indicated with a yellow dashed ...
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Stem cell therapies for retinal diseases: recapitulating development to replace degenerated cells
... stem cell-derived RPE cells has already entered early stage clinical trials, and is demonstrating safety and indications of ...candidate retinal cell entering the ...other retinal cell ...
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WNT signaling determines tumorigenicity and function of ESC derived retinal progenitors
... of 4,488 genes showed differences in expression at the level of 2-fold and more (P < 0.05). These genes primarily encoded mole- cules associated with neural differentiation, eye development, and WNT signaling (DAVID ...
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