retinoic acid-inducible gene 1
The development of recombinant Adenoviral vaccines to target pneumovirus infection
... Upon infection, RSV enters the respiratory tract, where it infects lung epithelial cells. This stimulates Toll-like receptors (TLRs); TLR3/9 recognises double-stranded RNA and TLR7/8 recognise single-stranded RNA (Kawai, ...
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Gene Expression of Nucleic Acid-Sensing Pattern Recognition Receptors in Children Hospitalized for Respiratory Syncytial Virus-Associated Acute Bronchiolitis
... in acid nucleic recognition in the initiation of innate immunity and the orchestration of adaptive immunity, the aim of this study was to determine whether any heterogeneity of PRR expression in the airway tracts ...
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Human serum RNase-L level is inversely associated with metabolic syndrome and age
... well. Retinoic acid-inducible gene 1 (RIG-1), in turn, is activated by these cleavage RNAs, and the down- stream signals trigger the production of inflammatory cytokines, such as ...
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Interactions between the Influenza A Virus RNA Polymerase Components and Retinoic Acid-Inducible Gene I
... Interactions between viral proteins and host factors govern the adaptation and pathogenicity of viruses in different hosts. In this regard, the influenza virus RNP complex plays a vital role (6, 63, 64). Influenza virus ...
16
Mismatches in the Influenza A Virus RNA Panhandle Prevent Retinoic Acid-Inducible Gene I (RIG-I) Sensing by Impairing RNA/RIG-I Complex Formation
... To study the effect of these mismatches on RIG-I activation, we designed synthetic dsRNAs based on the H1N1 Taiwan NS seg- ment that mimic the influenza virus panhandles, with or without mismatches (see Fig. 1A and 3A). ...
5
Coexpressed RIG-I Agonist Enhances Humoral Immune Response to Influenza Virus DNA Vaccine
... applications. Retinoic acid-inducible gene I (RIG-I) is a critical cytoplasmic double-stranded RNA (dsRNA) pattern receptor re- quired for innate immune activation in response to viral ...
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Retinoic acid inducible gene I Activates innate antiviral response against human parainfluenza virus type 3
... Human parainfluenza virus type 3 (HPIV3) is an envel- oped non-segmented negative-sense single stranded (NNS) RNA virus that belongs to the paramyxovirus fam- ily [1]. HPIV3 is a lung tropic virus known to cause ...
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Inhibition of Retinoic Acid-Inducible Gene I-Mediated Induction of Beta Interferon by the NS1 Protein of Influenza A Virus
... Based on the proposed central role for RIG-I as a cellular sensor of viral products resulting in activation of IRF-3 and induction of IFN-  and also based on the fact that the NS1 of influenza virus inhibits the ...
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ERF and ETV3L are retinoic acid inducible repressors required for primary neurogenesis
... Knockdown of ERF or ETV3/3L expanded the Geminin and Zic2 expression domain comparable with that observed in Rarα-MO and Rarγ-MO embryos. Expansion of Zic2 leads to the inhibition of Xngnr-1, which normally ...
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Dengue Virus Subverts the Interferon Induction Pathway via NS2B/3 Protease-IκB Kinase ε Interaction
... the retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) are important PRRs that recognize the viral rep- lication intermediate, double-stranded RNA (dsRNA) ...
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Rotavirus nonstructural protein 1 antagonizes innate immune response by interacting with retinoic acid inducible gene I
... NSP1 inhibits RIG-I mediated IFN- b promoter activation To investigate further the potential host target of NSP1, we tested the inhibition effects of NSP1 on IFN-b pro- moter activation induced by several key innate ...
9
COMPREHENSIVE REVIEW ON TREATMENT OF CANCER USING RETINOIC ACID RECEPTORS
... Retinol and vitamin A derivatives influence cell differentiation, proliferation and apoptosis and play an important physiologic role in a wide range of biological processes. Retinol is obtained from foods of animal ...
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Human primary airway epithelial cells isolated from active smokers have epigenetically impaired antiviral responses
... CS affects the first lines of defense by increasing air- way epithelial permeability, causing tissue disruption, and decreasing mucociliary clearance [33]. Many studies have shown that CS exerts detrimental effects on ...
11
RIPPLY3 is a retinoic acid inducible repressor required for setting the borders of the pre placodal ectoderm
... mRNA (indicated in Fig. 9). mCherry mRNA was added to each injection solution to keep the total amount of mRNA constant. Embryos were allowed to develop until stage 11, and then homogenized in 10 l/embryo lysis buffer ...
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Engineering Saccharomyces ceresisiae for the Secretion of an Extracellular Lipase
... be genetically modified to produce selected substances in relatively high amounts. Additionally, S. cerevisiae has emerged as a viable and versatile host for the synthesis of lipid compounds of high commercial interest ...
94
A phosphorylation defective retinoic acid receptor mutant mimics the effects of retinoic acid on EGFR mediated AP-1 expression and cancer cell proliferation
... binding to nuclear receptor corepressors such as NCoR and SMRT in the absence of ligand inhibits activation of RA responsive genes [3,4]. Ligand binding displaces the repressors and recruits coactivator proteins such as ...
9
TBX1, a DiGeorge syndrome candidate gene, is inhibited by retinoic acid
... Whole-mount in situ hybridization was performed essentially as de- scribed using digoxigenin antisense riboprobes constructed from linear- ized plasmids (Alexander et al., 1998). Plasmids encoding zebrafish ventricular ...
7
The retinoic acid receptor-α modulators ATRA and Ro415253 reciprocally regulate human IL-5+ Th2 cell proliferation and cytokine expression
... Figure 1 may be due to several potential mechanisms, including: enhanced Th2 differentiation, enhanced Th2 cytokine expression, pre- ferential Th2 proliferation, or inhibition of Th2 ...
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Characterisation of chicken RXR-γ
... didehydroretinoic acid (DD) and the synthetic retinoid p-(([E]-2-[5,6,7,8-tetrahydro- 5,5,8,8-tetramethyl-2-naphtyl-6,7-propenyl))benzoic acid (TTNPB or ...
250
Modulation of procollagen gene expression by retinoids Inhibition of collagen production by retinoic acid accompanied by reduced type I procollagen messenger ribonucleic acid levels in human skin fibroblast cultures
... of retinoic acid ethyl ester (RO-10-9359) resulted in a slight increase in procollagen production in these ...all-trans-retinoic acid was accompanied by a similar reduction in pro alpha 2(I) ...
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