Retinoic Acid Receptor
The retinoic acid receptor-α modulators ATRA and Ro415253 reciprocally regulate human IL-5+ Th2 cell proliferation and cytokine expression
... Retinoic acid (RA) is the bioactive form of vitamin A; all-trans-retinoic acid (ATRA) is the most abundant form of RA found in the ...inoic acid receptor (RAR) deficient mice ...
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Characterization of cDNAs encoding two chick retinoic acid receptor alpha isoforms and distribution of retinoic acid receptor alpha, beta and gamma transcripts during chick skin development
... Int J De, BioI 39 587 596 (1995) Original Article Characterization of cDNAs encoding two chick retinoic acid receptor a isoforms and distribution of retinoic acid receptor a, Band y transcripts during[.] ...
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All trans retinoic acid modulates the retinoic acid receptor alpha in promyelocytic cells
... all-trans retinoic acid (RA), the active metabolite of vitamin A, is an efficient alternative to chemotherapy in the treatment of acute promyelocytic leukemia ...the retinoic acid ...
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Fenretinide mediated retinoic acid receptor signalling and inhibition of ceramide biosynthesis regulates adipogenesis, lipid accumulation, mitochondrial function and nutrient stress signalling in adipocytes and adipose tissue
... In addition to the bene fi cial effect of FEN in vivo, we recently demonstrated that FEN (similarly to RA) is able to inhibit 3T3- L1 adipocyte differentiation by blocking transcription of C/EBP a and PPAR g , master ...
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Tissue expression of retinoic acid receptor alpha and CRABP2 in metastatic nephroblastomas
... cellular retinoic acid-binding protein 2 (CRABP2) and to the ac- tivity on RA receptors, designated retinoic acid receptors (RARs) and retinoid X receptors (RXRs) [8 – ...10]. Retinoic ...
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Role of the retinoic acid receptor beta (RARbeta) during mouse development
... Int J Un Bioi ~I ~25 ~~7 (19nl Original A rlirl,' Role of the retinoic acid receptor beta (RAR~) during mouse development NORBERT B GHYSELINCK VALERIE DUPE ANDREE DIE RICH, NADIA MESSADDEO, JEAN MARIE[.] ...
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All trans retinoic acid converts E2F into a transcriptional suppressor and inhibits the growth of normal human bronchial epithelial cells through a retinoic acid receptor dependent signaling pathway
... to retinoic acid receptor- and E2F-dependent pathways as potential mediators of retinoid-induced growth arrest in normal HBE cells and have implications for the use of retinoids in clinical trials on ...
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Hypermethylation and loss of retinoic acid receptor responder 1 expression in human choriocarcinoma
... cently, retinoic acid receptor responder 1 ( RARRES1 ), also known as Tazarotene-induced gene 1 ( TIG1 ), was identified as an important tumor suppressor gene [4, ...novel retinoic acid ...
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Rearrangements of the retinoic acid receptor alpha and promyelocytic leukemia zinc finger genes resulting from t(11;17)(q23;q21) in a patient with acute promyelocytic leukemia
... Cytogenetic study of a patient with acute promyelocytic leukemia (APL) showed an unusual karyotype 46,xy,t(11;17) (q23;21) without apparent rearrangement of chromosome 15. Molecular studies showed rearrangements of the ...
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CaMKII regulates retinoic acid receptor transcriptional activity and the differentiation of myeloid leukemia cells
... Retinoic acid receptors (RARs) are members of the nuclear hormone receptor family and regulate the proliferation and differentiation of multiple different cell types, including promyelocytic leukemia ...
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Retinoic acid receptor regulation of epimorphic and homeostatic regeneration in the axolotl
... of retinoic acid receptors (RAR α , RAR β and RAR γ ...to retinoic acid DNA response elements (RAREs) located near RA target genes (Chambon, ...
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A fourth subtype of retinoic acid receptor-related orphan receptors is activated by oxidized all-trans retinoic acid in medaka (Oryzias latipes)
... Luciferase reporter assay for medaka bmal1a or cyp26a1 The entire protein-encoding region (corresponding to amino acids 1–473) and stop codon of the medaka rord1 (the same amino acid sequence used in phylogenetic ...
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Induction of intermediate mesoderm by retinoic acid receptor signaling from differentiating mouse embryonic stem cells
... and retinoic acid (RA) on the induction of intermediate mesoderm from mESCs under defined, serum-free, adherent, monolayer culture ...RA receptor (RAR) agonist, but not by retinoid X receptor ...
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Identification and Characterization of Human Genomic Binding Sites for Retinoic Acid Receptor/Retinoid X Receptor Heterodimers
... the retinoic acid receptors (RARs), which is a member of the nuclear receptor super ...to retinoic acid response elements ...synthetic retinoic acids have been widely used and ...
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Retinoic acid receptor signaling is necessary in steroidogenic cells for normal spermatogenesis and epididymal function
... Previous studies have shown that all three RAR isomers are expressed in the epididymis and lack of RA results in epithelial cells of the epididymis undergoing squamous metaplasia (Wan et al., 1992; Akmal et al., 1996; ...
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A phosphorylation defective retinoic acid receptor mutant mimics the effects of retinoic acid on EGFR mediated AP-1 expression and cancer cell proliferation
... type receptor possessed slight anti- AP-1 activity in the absence of ligand (20% reduction compared to control cells transfected with blank expres- sion ...
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Human skin levels of retinoic acid and cytochrome P 450 derived 4 hydroxyretinoic acid after topical application of retinoic acid in vivo compared to concentrations required to stimulate retinoic acid receptor mediated transcription in vitro
... individual retinoic acid receptors (RARs) or retinoid X receptor-alpha (RXR-alpha) and a chloramphenicol acetyl transferase (CAT) reporter plasmid containing a retinoic acid responsive ...
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Retinoid X receptor and retinoic acid response in the marine sponge Suberites domuncula
... cystophora retinoic acid X receptor (RXR_TRICYS; AF091121), Platyhelminthes Schistosoma mansoni retinoic acid receptor RXR (RXR_SCHMA; AF094759) and ...X receptor RXR-2 ...
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Molecular evolution and expression profile of the chemerine encoding gene RARRES2 in baboon and chimpanzee
... the retinoic acid receptor responder 2 (RARRES2) gene is an adipocytesecreted protein with autocrine/paracrine functions in adipose tissue, metabolism and inflammation with a recently described ...
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<p>A rare case of acute promyelocytic leukemia with IRF2BP2-RARA fusion; and literature review</p>
... Acute promyelocytic leukemia (APL) is characterized by the fusion of retinoic acid receptor alpha (RARA) with promyelocytic leukemia (PML). In addition, about 2% APL patients present variant fusions. ...
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