Retinoid X Receptor
Retinoid X Receptor Antagonists
... Retinoid X receptor (RXR) antagonists are not only useful as chemical tools for biological research, but also are candidate drugs for treatment of various diseases, including diabetes and allergy, ...
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Activation of retinoid X receptor by bexarotene attenuates neuroinflammation via PPARγ/SIRT6/FoxO3a pathway after subarachnoid hemorrhage in rats
... Retinoid X receptor (RXR) is a member of the NR2B nuclear receptor ...hormone receptor superfamily and exerts an anti-inflammatory effect in many neurological diseases ...
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Retinoid X receptor and retinoic acid response in the marine sponge Suberites domuncula
... acid X receptor (RXR_TRICYS; AF091121), Platyhelminthes Schistosoma mansoni retinoic acid receptor RXR (RXR_SCHMA; AF094759) and ...mansoni retinoid X receptor RXR-2 mRNA ...
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Vitamin D receptor, Retinoid X receptor and peroxisome proliferator-activated receptor γ are overexpressed in BRCA1 mutated breast cancer and predict prognosis
... estrogen receptor, progesterone receptor and/or ...D Receptor (VDR), Retinoid X Receptor (RXR) and Peroxisome Proliferator-activated Receptor γ (PPAR γ ) are known to ...
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Proteasomal degradation of retinoid X receptor α reprograms transcriptional activity of PPARγ in obese mice and humans
... partner retinoid X receptor α (RXRα), but not RXRβ, in visceral WAT from obese humans and ...for retinoid and thyroid hormone receptors (SMRT) upon agonist ...
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Retinoid X receptor alpha transactivates the hepatitis B virus enhancer 1 element by forming a heterodimeric complex with the peroxisome proliferator-activated receptor.
... Human hepatitis B virus (HBV) infectivity is characterized by a marked hepatotropism. The pathological manifestations of HBV infection include cirrhosis of the liver, which can lead to liver failure and death (11). ...
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Dual targeting of retinoid X receptor and histone deacetylase with DW22 as a novel antitumor approach
... Retinoid X receptor (RXR), a well-known molecular target in several human tumors [6], executes its biological functions with retinoid acid receptor (RAR) to modulate the transcriptional ...
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An antagonist of the retinoid X receptor reduces the viability of Trichuris muris in vitro
... functional receptor, sequence conservation was analysed more ...a retinoid X receptor, is does suggest that it is a functional nuclear hormone receptor and is closely related to the RXR ...
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Silencing Retinoid X Receptor Alpha Expression Enhances Early-Stage Hepatitis B Virus Infection In Cell Cultures
... farnesoid X receptor (FXR), hepatocyte nuclear factor 4 ␣ (HNF-4 ␣ ), peroxisome proliferator-activated receptor alpha (PPAR ␣ ), retinoid X receptor alpha (RXR ␣ ), and ...
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The retinoid X receptor from mud crab: new insights into its roles in ovarian development and related signaling pathway
... arthropods, retinoid X receptor (RXR) is a highly conserved nuclear hormone ...ecdysone receptor (EcR), RXR is known to be vital importance for various physiological ...
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Interaction of human beta 1 thyroid hormone receptor and its mutants with DNA and retinoid X receptor beta T3 response element dependent dominant negative potency
... hormone receptor (h-TR beta) gene are associated with the syndrome of generalized resistance to thyroid ...with retinoid X receptor beta (RXR ...
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Retinoids increase human apo C III expression at the transcriptional level via the retinoid X receptor Contribution to the hypertriglyceridemic action of retinoids
... the retinoid X receptor (RXR), since LG1069 (4-[1-(5,6,7,8- tetrahydro-3,5,5,8,8-pentamethyl-2-naphtalenyl)ethenyl]ben- zoic acid), a RXR-specific agonist, but not TTNPB (( E ) - ...
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Mitogen activated protein kinase inhibits 1,25 dihydroxyvitamin D3–dependent signal transduction by phosphorylating human retinoid X receptor α
... retinoid X receptor α (hRXRα) is the predominant RXR expressed in these cells (17). Interestingly, VDR/RXR com- plexes formed on vitamin D response element (VDRE) oligonucleotides can be supershifted ...
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Original Article Retinoid X receptor ligand regulates RXRα/Nur77-dependent apoptosis via modulating its nuclear export and mitochondrial targeting
... nuclear receptor family, it can form different source dimers with other nuclear receptors, thus be involved in cellular signal transduction ...nuclear receptor, and our research is mainly on the study of ...
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Retinoid X receptor alpha is a spatiotemporally predominant therapeutic target for anthracycline-induced cardiotoxicity
... tion of two large-scale human genetic studies revealed rs2229774 [retinoic acid receptor (RARG)] and rs28714259 (intergenic region) as two susceptible variants to AIC (9, 10). Through a GWAS analysis of decline ...
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Effect of a retinoid X receptor partial agonist on airway inflammation and hyperresponsiveness in a murine model of asthma
... The levels of IL-5 and IL-13 in the culture supernatant in OVA-re-stimulated lung MNCs isolated from OVA-sensitized and -challenged mice were significantly suppressed in OVA/OVA/NEt-4IB [r] ...
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Retinoid X receptor and peroxisome proliferator activated receptor gamma agonists cooperate to inhibit matrix metalloproteinase gene expression
... To further investigate this mechanism, we returned to the PPAR literature. The model describing inhibition of proinflam- matory genes by a SUMOylated form of PPAR proposed by Pascual and colleagues [14] is attractive ...
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<p>Synergistic effect of a retinoid X receptor-selective ligand bexarotene and docetaxel in prostate cancer</p>
... Cyclin D1 is involved in G1/S transition, 21 but the results of cell cycle analysis showed no DTX-induced G1/S arrest, suggesting an insigni fi cant role for cyclinD1 in the combination t[r] ...
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Studies of the expression and function of the retinoid-x-receptor y gene in rodent embryonic development
... R X R y is expressed prior to differentiation during the early stages of myogenesis because the Myf-5 gene, which is coexpressed with RXRy, is expressed prior to, as well as after the initiation of skeletal muscle ...
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A retinoid X receptor partial agonist attenuates pulmonary emphysema and airway inflammation
... proliferator-activated receptor γ (PPARγ) were reported to exhibit enhanced cigarette smoke (CS)-induced airway inflammation and emphysematous changes in the lungs ...liver X receptor (LXR) in the ...
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