Reverse Transcriptase Inhibitors
AZOLES AS NON NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS (NNRTIs): MINI REVIEW
... anti-reverse transcriptase inhibitors, are significantly ...HIV-1 reverse transcriptase inhibitors activity (Pauwels et ...
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A Novel Molecular Mechanism of Dual Resistance to Nucleoside and Nonnucleoside Reverse Transcriptase Inhibitors
... HIV-1 reverse transcriptase (RT) were observed to exhibit dual resistance to nucleoside and nonnucleoside reverse transcriptase inhibitors (NRTIs and ...
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Susceptibility of Human Endogenous Retrovirus Type K to Reverse Transcriptase Inhibitors
... of reverse transcriptase inhibitors in HK2 viral ...these inhibitors interfere with the replication capacity of the viral genome of HK2 virus particles released by NCCIT ...of ...
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Comparative Study of Various Non-Nucleoside Reverse Transcriptase Inhibitors on Different Reverse Transcriptase Enzyme
... nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs/ NTRIs) and non-nucleoside reverse tran- scriptase inhibitors (NNRTIs), protease inhibitors and HIV integrase ...
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Susceptibility of lamivudine resistant hepatitis B virus to other reverse transcriptase inhibitors
... The emergence of resistant hepatitis B virus (HBV), with mutations in the YMDD motif of the poly- merase gene after treatment with lamivudine, is becoming an important clinical problem. In this study, susceptibility of ...
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AN INSIGHT TO STRUCTURAL ANALYSIS OF COUMARINS AS NON NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS
... Standard regimen of anti-retroviral therapy (ART) consists of two NRTIs plus one NNRTI or protease inhibitors (PI). NNRTI has been one of the key components against HIV-1 replication and infection. Nevirapine ...
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(Alkylamino) piperidine bis(heteroaryl)piperizine analogs are potent, broad-spectrum nonnucleoside reverse transcriptase inhibitors of drug-resistant isolates of human immunodeficiency virus type 1 (HIV-1) and select for drug-resistant variants of HIV-1IIIB with reduced replication phenotypes.
... potent inhibitors of NNRTI-resistant ...broad-spectrum inhibitors involved the in vitro screening of a diverse series of BHAP analogs against recombinant RTs car- rying either the Pro-2363Leu or Tyr-1813Cys ...
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Virtual Screening for Novel HIV-Reverse Transcriptase Inhibitors
... HIV–1 (human immunodeficiency virus type–1) is the disease causing agent for AIDS. It is pathogenic retrovirus which joined in a long polypeptide chain when viral RNA is translated into a polypeptide sequence. It ...
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HIV-1 and HIV-2 Reverse Transcriptases: Different Mechanisms of Resistance to Nucleoside Reverse Transcriptase Inhibitors
... virus. Reverse transcriptase (RT) is an enzyme that contains two enzymatic activities, a DNA polymerase that can copy either an RNA or DNA template, and an RNase H, which degrades RNA if the RNA is part of ...
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Development of QSAR model for indoyl aryl sulfone derivatives as reverse transcriptase inhibitors
... marketed drugs nevirapine, delaviridine, and efavirenz are significant example of such inhibitors. At the molecular level NNTRIs act by a specific allosteric effect arising from noncompetitive binding to a ...
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PROGRESS AND PROSPECTS IN THERAPEUTICS AGAINST HIV INFECTION
... nucleoside reverse transcriptase inhibitors (NsRTIs) plus a third antiretroviral drug for treatment-naive patients with AIDS that include non- nucleoside reverse transcriptase ...
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Post-exposure prophylaxis for non-occupational exposure to HIV: experience in NSW one year after the introduction of the guidelines
... For percutaneous exposures, where the source is known to be HIV positive and with a significant blood exposure to high HIV titre, PEP comprising triple-combination therapy (two nucleoside reverse ...
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Rilpivirine analogs potently inhibit drug resistant HIV 1 mutants
... Nonnucleoside reverse transcriptase inhibitors (NNRTIs) are a class of antiretroviral compounds that bind in an allosteric binding pocket in HIV-1 RT, located about 10 Å from the polymerase active ...
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Non-Hepatic Adverse Effects of Antiretroviral Therapy for HIV Treatment and Care
... Nucleoside Reverse Transcriptase Inhibitors: NRTIs are the backbone of ART and are majorly associated with lactic acidosis and lipodystrophy ...
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Antiretroviral resistance in HIV 1 patients at a tertiary medical institute in Saudi Arabia: a retrospective study and analysis
... 3 Comparison of the resistance causing mutations reported internationally and at KFSH&RC in the NRTI’s nucleoside reverse transcriptase inhibitors group of ART.. The Blue ribbon represen[r] ...
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Selection and analysis of human immunodeficiency virus type 1 variants with increased resistance to ABT-538, a novel protease inhibitor.
... including reverse transcriptase, integrase, and protease ...Unlike reverse transcriptase inhibitors, which are only effective in blocking viral replication in acutely infected cells, ...
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Human Immunodeficiency Virus Type 1: Resistance to Nucleoside Analogues and Replicative Capacity in Primary Human Macrophages
... nucleoside reverse transcriptase inhibitors (NRTIs) are one of the main drug classes used in the treatment of human immunodeficiency virus type 1 (HIV-1) ...inhibit reverse transcription ...
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Early loss of bone mineral density is correlated with a gain of fat mass in patients starting a protease inhibitor containing regimen: the prospective Lipotrip study
... nucleoside reverse transcriptase inhibitors (NRTI) and of protease inhibitors (PI) on adipose tissue differentiation and on lipid metabolism have been described ...non-nucleosidic ...
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Viral Evolution in Response to the Broad-Based Retroviral Protease Inhibitor TL-3
... with reverse transcriptase inhibitors in combination with protease inhibitors has proven to suppress human immunodeficiency virus type 1 (HIV-1) replication to undetectable levels in patients ...
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Once-Daily Highly Active Antiretroviral Therapy for HIV-Infected Children: Safety and Efficacy of an Efavirenz-Containing Regimen
... bility and effectiveness of a once-daily regimen of efavirenz with 3 nucleoside reverse transcriptase inhibitors as first-line or second-line highly active antiretro- viral therapy in a [r] ...
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