Rhabdoid tumors
Identification of RPL5 and RPL10 as novel diagnostic biomarkers of Atypical teratoid/rhabdoid tumors
... Rhabdoid tumors (RTs) are aggressive tumors that occur most frequently in children under 2 years ...term rhabdoid in describing KRT, due to the close histological resemblance of the tumor ...
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Loss of expression of the Neural Cell Adhesion Molecule 1 (NCAM1) in atypical teratoid/rhabdoid tumors: a new diagnostic marker?
... Malignant rhabdoid tumors (MRT) are highly aggressive em- bryonal ...teratoid/rhabdoid tumors (AT/RT) ...all rhabdoid tumors, while 5–10% are originated in the kidneys and are ...
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Atypical teratoid rhabdoid tumors: a population-based clinical outcomes study involving 174 patients from the Surveillance, Epidemiology, and End Results database (1973–2010)
... teratoid rhabdoid tumors (ATRTs) are rare, highly malignant embryonal tumors of the central nervous system (CNS) accounting for 20% of CNS tumors in children under the age of ...
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Dual Targeting of PDGFRα and FGFR1 Displays Synergistic Efficacy in Malignant Rhabdoid Tumors.
... Subunits of the SWI/SNF chromatin remodeling complex are mutated in a significant proportion of human cancers. Malignant rhabdoid tumors (MRTs) are lethal pediatric cancers characterized by a deficiency in ...
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Imaging Findings of CNS Atypical Teratoid/Rhabdoid Tumors
... of tumors of the CNS in 2000, although it had been recognized during the early 1980s as a rhabdoid tu- mor of the CNS with an unfavorable ...These tumors can arise at any location in the CNS, with ...
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Atypical Teratoid/Rhabdoid Tumors in Adult Patients: CT and MR Imaging Features
... the tumors appeared isoattenuated, and 1 of the 2 tumors contained ...the tumors on MR imaging were isointense on T1-weighted, T2-weighted, and FLAIR images, and 1 case showed restricted diffusion on ...
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Primary Intracranial Atypical Teratoid/Rhabdoid Tumors of Infancy and Childhood: MRI Features and Patient Outcomes
... RESULTS: Patients ranged in age from 4 months to 15 years (median age, 2.9 years). Primary AT/RTs were intra-axial in 94% of patients. The single primary extra-axial lesion was located in the cerebellopontine angle ...
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Disrupting LIN28 in atypical teratoid rhabdoid tumors reveals the importance of the mitogen activated protein kinase pathway as a therapeutic target
... teratoid rhabdoid tumor (AT/RT) is among the most fatal of all pediatric brain ...primary tumors and cell lines, with corresponding low levels of the LIN28- regulated microRNAs of the let-7 ...primary ...
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Atypical teratoid/rhabdoid tumors: challenges and search for solutions
... AT/RTs are aggressive CNS malignancies that require multimodality approach consisting of maximal safe sur- gery, chemotherapy, and radiotherapy. Intensive multiagent chemotherapy with alkylating agents, anthracyclines, ...
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Identification of novel binding targets of the SWI_SNF complex member SNF5 in malignant rhabdoid tumors
... GDF15 (Growth Differentiation Factor 15, NAG1, MIC-1) is a potential tumor suppressor gene that is regulated by histone acetylation (45). There is some evidence that this gene is down regulated in some brain ...
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Extraordinary disease free survival in a rare malignant extrarenal rhabdoid tumor: a case report and review of the literature
... renal rhabdoid tumors are rare, no standard therapeutic pathway exists and no randomized trials that examine the role of chemotherapy combinations or addition of new drugs have been ...
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Case Report Rhabdoid variant of urothelial carcinoma of the urinary bladder: a case report with emphasis on immunohistochemical analysis regarding the formation of rhabdoid morphology
... with rhabdoid morphology developed from the same clone as that of the non-invasive tumor cells even though the transition between them was ...malignant rhabdoid tumor of the kidney ...
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SMARCB1- and vimentin-positive esophageal carcinoma with undifferentiated components, rhabdoid features, and a good prognosis: a case report
... prominent rhabdoid features has been identified as a distinct aggressive type of malignancy [11–14], since the tumor is occasionally negative for one of the tumor-suppressor gene products, SWI/SNF-related ...
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Original Article Clear cell renal cell carcinoma with rhabdoid differentiation: report of 10 Chinese cases supporting a distinctive variant
... with rhabdoid differentiation should be dif- ferentiated from renal tumors with rhabdoid ...by rhabdoid features [18, ...Malignant rhabdoid tumor (MRT) of the kidney rarely occurs in ...
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Original Article Epithelioid sarcoma of the scalp: a case report and literature review
... epithelioid tumors by INI stains ...malignant tumors such as syno- vial sarcoma, epithelioid angiosarcoma, and malignant rhabdoid tumors of the ...malignant rhabdoid tumor (MRT), which ...
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Epigenetic synthetic lethality approaches in cancer therapy
... teratoid/rhabdoid tumors; BRCA1/2: Breast cancer type 1/2; CDK1: Cyclin-dependent kinase1; CREB1: CAMP Responsive Element Binding Protein 1; CREBBP: CREB Binding Protein; CRISPR: Clustered regularly ...
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A remarkably simple genome underlies highly malignant pediatric rhabdoid cancers
... 35 rhabdoid tumors, highly aggressive cancers of early childhood characterized by biallelic loss of SMARCB1, a subunit of the SWI/ SNF chromatin remodeling ...
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Primary Vulval Rhabdoid Tumor in an Adult: A Case Report, Immunohistochemical Profile and Literature Review
... Extrarenal malignant rhabdoid tumors (EMRTs) are rare and highly aggressive neoplasms. Although they are known to occur during infancy and childhood, their occurrence in adults is reported. EMRTs were ...
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Sporadic haemangioblastoma of the kidney with rhabdoid features and focal CD10 expression: report of a case and literature review
... Renal haemangioblastoma (RHB) is extremely uncom- mon since only four cases were definitely reported pre- viously (Table 2). Our case was specifically in line with the diagnostic clues of RHB suggested by Ip et al [5] ...
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Case Report Coexistent loss of INI1 and BRG1 expression in a rhabdoid renal cell carcinoma (RCC): implications for a possible role of SWI/SNF complex in the pathogenesis of RCC
... tinct tumors are associated with the loss expression of this protein ...malignant tumors with rhabdoid morphology including pediatric renal and extrarenal malignant rhabdoid tum- ors, atypical ...
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