Rho GTPase activating protein
Control of Polarized Growth by the Rho Family GTPase Rho4 in Budding Yeast: Requirement of the N-Terminal Extension of Rho4 and Regulation by the Rho GTPase-Activating Protein Bem2
... six Rho GTPases in the budding yeast but is com- mon in Rho4 homologs in other yeasts and filamentous ...a Rho GTPase-activating pro- tein (RhoGAP) for Cdc42 and Rho1, by yeast two-hybrid, ...
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The Rgd1p Rho GTPase-Activating Protein and the Mid2p Cell Wall Sensor Are Required at Low pH for Protein Kinase C Pathway Activation and Cell Survival in Saccharomyces cerevisiae
... YPD medium. Transcription of SLT2 is activated slightly, ap- proximately twice as much, while that of PST1, one of the outputs of Slt2 activation, is activated up to fivefold. In this study, we described how the ...
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Rho GTPase activating protein 18: a biomarker associated with good prognosis in invasive breast cancer
... The associations of both nuclear and cytoplasmic ARGAP18 with the cadherin switch in the current data; E-cadherin loss and N-cadherin gain, as well as the negative association with the EMT triggers TGFβ1 and PIK3CA (Zhao ...
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Secretory Pathway-Dependent Localization of the Saccharomyces cerevisiae Rho GTPase-Activating Protein Rgd1p at Growth Sites
... tory vesicles when SEC6 is impaired (24, 27, 78). A strain (7165) with the sec6-4 mutation expressing Rgd1p-6⫻HA from its chro- mosomal locus and containing the pUG36-GFP-SEC4 plasmid expressing GFP-Sec4p from the MET25 ...
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RPE phagocytic function declines in age related macular degeneration and is rescued by human umbilical tissue derived cells
... two Rho GTPase effectors, PLD1 and PAK3, were upregulated by the treatment, suggesting that hUTC-secreted RTK ligands, such as GDNF, BDNF and HGF, and possibly other RTK ligands and factors, could enhance ...
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‘Medusa head ataxia’: the expanding spectrum of Purkinje cell antibodies in autoimmune cerebellar ataxia. Part 2: Anti-PKC-gamma, anti-GluR-delta2, anti-Ca/ARHGAP26 and anti-VGCC
... ARHGAP26: Rho GTPase-activating protein 26; ATXN1: ataxin-1; BAR: Bin – amphiphysin – Rvs; beta-NAP: neuronal adaptin-like protein; CARP VIII: carbonic anhydrase- related protein ...
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Antibodies to the inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) in cerebellar ataxia
... anti-Rho GTPase-activating protein 26 (ARH- GAP26) (Santa Cruz, Heidelberg, Germany); goat anti- Homer3 (Santa Cruz); rabbit anti-protein kinase C gamma (PKCγ) (Santa Cruz); mouse ...
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GTPase-Activating Proteins for Cdc42
... The Rho-type GTPase, Cdc42, has been implicated in a variety of functions in the yeast life cycle, including septin organization for cytokinesis, pheromone response, and haploid invasive ...called ...
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Hyphal Guidance and Invasive Growth in Candida albicans Require the Ras-Like GTPase Rsr1p and Its GTPase-Activating Protein Bud2p
... and Rho-type GTPases regulate many morphogenetic processes in eukaryotes, including polarity establishment, cell proliferation, and directed growth in response to extracellular ...Ras-like GTPase Rsr1p and ...
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Isolation and characterisation of α2-chimaerin cDNA encoding a p21rac GTPase-activating protein with an SH2 domain
... a protein that has extensive sequence similarity to a putative heterogeneous nuclear RNP protein, GRP33; it contains a tyrosine-rich region at the carboxyl terminal, and it is able to bind RNA (Wong et ...
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Ras GTPase-Activating Protein Regulation of Actin Cytoskeleton and Hyphal Polarity in Aspergillus nidulans
... Ras-like protein that does not appear to play a role in hyphal growth ...second protein (the AN3434 product [branch 4]) is more distantly related to RasA/B and, notably, appears to be specific of aspergilli ...
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Lrg1p Is a Rho1 GTPase-Activating Protein Required for Efficient Cell Fusion in Yeast
... Lrg1p protein is depicted ...for Protein Sequences ...a Rho GAP homology domain (755–910 aa) are represented by the open ...the Rho-GAP homology domain (rhoGAP⌬) are indicated by the ...
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Regulation and structure/function relationships of the Rac1 GTPase-activating protein, n-chimaerin
... inactivates Rho by ADP-ribosylation at residue Asn41 (Paterson et a l , ...of Rho in cells involved microinjecting recombinant Rho proteins into fibroblasts (Ridley and Hall, ...G14VRhoA ...
278
Purification and functional characterization of brain and recombinant chimaerin, a p21rac GTPase activating protein
... the GTPase activity of microinjected ras (Trahey and McCormick, ...membrane protein that is heavily tyrosine phosphorylated in stimulated ...hnRNP protein, GRP33, and recombinant p62 binds nucleic ...
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Biochemical characterisation of rho/rac GTPases and their GTPase activating proteins in humans and Dictyostelium discoideum
... Initial experiments with rhoA sought to determine what fluorescent changes, if any, occurred when mant nucleotides bound to rhoA, and also during mantGTP cleavage to mantGDP. The stoichiometric rhoA.mantGTP 1:1 complex ...
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The Arf GTPase Activating Protein Family Is Exploited by Salmonella enterica Serovar Typhimurium To Invade Nonphagocytic Host Cells
... The members of the human Arf GAP family exhibit diverse Arf substrate specificities and can be divided into subfamilies known as ACAP, ADAP, ARAP, ASAP, ArfGAP, and GIT (14) (see Ta- ble S1 in the supplemental material). ...
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The Arf-GTPase-Activating Protein Gcs1p Is Essential for Sporulation and Regulates the Phospholipase D Spo14p
... SPO14, encoding the major Saccharomyces cerevisiae phospholipase D (PLD), is essential for sporulation and mediates synthesis of the new membrane that encompasses the haploid nuclei that arise through meiotic divisions. ...
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Role of IQGAP3 in metastasis and epithelial–mesenchymal transition in human hepatocellular carcinoma
... binding protein-1 (LTBP1), 5 ′ -CTTGGGCTT- GAGCACGTATT-3 ′ (forward) and 5 ′ -GCCCAGAT- GACCTTAACCCT-3 ′ (reverse); and glyceraldehyde 3-phosphate dehydrogenase (GAPDH), 5 ′ -TTGAGGT- CAATGAAGGGGTC-3 ′ (forward) ...
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Lymphangioleiomyomatosis — a wolf in sheep’s clothing
... of activating and inactivating mutations revealed only TSC2 mutations and not mutations in TSC1, RHEB, or other candidate loci, consistent with a necessary and sufficient role for TSC muta- tions in the ...
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Regulation of localization and function of the Rho family small GTPase, Rnd3
... of protein-protein ...specific protein interacts have particular significance for the biological functions of that ...interacting protein partners for Rnd3, both to enhance understanding of ...
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