Rho GTPases
Rho GTPases – Emerging regulators of glucose homeostasis and metabolic health
... Keywords: Rho GTPases; Metabolism; Glucose homeostasis, GLUT4 translocation, skeletal.. 23.[r] ...
28
Rho GTPases Modulate Entry of Ebola Virus and Vesicular Stomatitis Virus Pseudotyped Vectors
... The viral GP/receptor interactions of EBOV and VSV are poorly understood, but both viruses have a broad but defined cell tropism (7, 25, 41, 45). As a first step in cell infection, entry by macropinocytosis is an ...
11
Rac and Rho GTPases in cancer cell motility control
... The Rac subfamily of Rho GTPases includes Rac1, Rac2, Rac3. Rac1 is over-expressed in various tumors and accumulating evidence indicate that Rac1-depen- dent cell signalling is important for malignant ...
14
Small Rho GTPases and Cholesterol Biosynthetic Pathway Intermediates in African Swine Fever Virus Infection
... of Rho family of small GTPases are essential key regulators of diverse critical cellular functions, including cyto- skeleton dynamics, cell cycle progression, migration, the genera- tion of reactive oxygen ...
10
The Rho GTPases Rac1, Cdc42, and RhoA Regulate APP Transport to Lysosomes and Aβ Production
... PIP5K is regulated upstream by a large number of proteins, most of which are activators of PIP5K and important to actin dynamics. The few that are most relevant to this study are Arf6, the Rho GTPases, and ...
138
DNA topoisomerase IIβ stimulates neurite outgrowth in neural differentiated human mesenchymal stem cells through regulation of Rho-GTPases (RhoA/Rock2 pathway) and Nurr1 expression
... Our findings suggest that Rho-GTPases can be a down- stream target of topo IIβ; however, knowledge on the upstream regulation of topo IIβ is also inadequate. Nurr1, a transcription factor belonging to the ...
14
Rho GTPases in A549 and Caco-2 cells dominating the endocytic pathways of nanocarbons with different morphologies
... of Rho GTPases on nanomaterials, the expression and the knock-down efficiency were first con- ...three Rho GTPase members was achieved by RNA ...
14
The involvement of Rho GTPases in plexin mediated signal transduction
... that Rho GTPases regulate axon outgrowth and ...Xenopus, Rho mutants exhibit irregular dendritic outgrowth and lack neurite extension (Luo et a l, 2000; Li et ...vitro Rho regulates neurite ...
231
Rho GTPases as therapeutic targets in Alzheimer’s disease
... Rho GTPases are an important target in human diseases such as Alzheimer’s disease (AD), cardiovascular, pulmon- ary, and neurological disorders, and cancers ...of Rho GTPases in AD ...
10
Rho GTPases and early zebrafish development
... the Rho GTPases ought to act as oncogenes, there was little if any evidence to support this until ...of Rho family members that were previously assumed to be equivalent, as well as providing possible ...
270
RhoGDI deficiency induces constitutive activation of Rho GTPases and COX-2 pathways in association with breast cancer progression
... GTPase activity assay is based on the high- affinity binding of GTP-bound GTPases to their specific effector proteins [49]. GTP-RhoA was detected using GST-rhotekin-Rho binding domain (RBD). GST-PAK1 ...
14
Leroy, Céline (2013): The role of Rho-GTPases in dendritic cell functions. Dissertation, LMU München: Medizinische Fakultät
... three Rho-GTPases were indispensable to take up dying cells, as this ability was impaired in every mouse strain (Figure ...several Rho-GTPase pathways in the Rac1N17 spleen ...different ...
98
Nanofibrillar scaffolds induce preferential activation of Rho GTPases in cerebral cortical astrocytes
... of Rho GTPase upstream regulators known to be associated with the morphological responses was demon- strated using ...the Rho GTPase family with demonstrable morphological consequences for cerebral cortical ...
15
Role of Rho GTPases and PTEN in the migration of human glioma cells
... Tumor suppressor PTEN inhibits integrin- and growth factor-mediated mitogen-activated protein (MAP) kinase signaling pathways, J Cell Biol 143,1375-83. Proliferation[r] ...
215
The evolutionary history of effectors downstream of Cdc42 and Rac
... small GTPases of the Rho family; these proteins are also important in regulating gene transcrip- ...of Rho GTPases - the Cdc42 and Rac subfamilies - are highly con- served amongst all ...
8
Distinct roles for the small GTPases Cdc42 and Rho in endothelial responses to shear stress
... that Rho GTPases bind to guanine nucleotide dissociation inhibitors (GDIs) in the ...stimulation, Rho GTPases dissociate from GDIs, translocate to the cell membrane, and become activated ...
11
Vascular endothelial growth factor (VEGF) regulation of endothelial cell behavior through the Rho family of small GTPases
... specific Rho GTPases, whereas some GEFs are more promiscuous so they activate multiple GTPases depending on the upstream ...of Rho GTPases by GEFs has been shown to stimulate ...
203
The Borg family of Cdc42 effector proteins Cdc42EP1-5.
... The activity of Borg proteins may also be regulated by alternative mechanisms. Cdc42EP2, Cdc42EP3 and Cdc42EP5 are direct substrates of the atypical MAP kinases ERK3 and MK5, and have been suggested to be relevant in the ...
8
Control of programmed cell death by Rho-like GTPases-activated signalling cascades in the developing neuron
... of Rho GTPases and stabilise the GDP-conformation by inhibiting the dissociation of GDP (Fukum oto et aL, 1990; Ueda et aL, ...that Rho GDIs could also associate w ith GTP-bound Rho, Rac and ...
237
Regulation of cell-cell adhesion in keratinocytes: The reciprocal relationship between cadherins and Rho family GTPases
... in tumorigenesis in vivo. Racl is upregulated at the RNA and protein level in breast cancer samples relative to samples from normal breast (Schnelzer et a l , 2000). High levels of active Rac3 have been demonstrated in ...
185