Ribosome biogenesis
Inhibiting eukaryotic ribosome biogenesis
... the ribosome synthe- sis pathway, we designed a strategy that allowed us to sys- tematically screen a large quantity of low molecular weight substances for effects on ribosome biogenesis in the yeast ...
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Trypanosoma brucei L11 Is Essential to Ribosome Biogenesis and Interacts with the Kinetoplastid-Specific Proteins P34 and P37
... Another possible explanation of these findings might be similar to observations in H. sapiens that the 5S RNP plays a role in helping resolve the disruption of proper ribosome biogenesis through interactions ...
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Notchless defines a stage specific requirement for ribosome biogenesis during lineage progression in adult skeletal myogenesis
... of ribosome formation promotes ribosomal proteins to bind to MDM2 and block MDM2-mediated p53 degradation, thereby inducing p53- dependent cellular responses including apoptosis and cell cycle arrest (Golomb et ...
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Location Is Everything: An Educational Primer for Use with “Genetic Analysis of the Ribosome Biogenesis Factor Ltv1 of Saccharomyces cerevisiae”
... 2013). Ribosome biogenesis involves many additional proteins and small RNAs that are responsi- ble for the multiple steps required to assemble the rRNA with ribosomal ...proteins. Ribosome assembly ...
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The tumor suppressor p53 connects ribosome biogenesis to cell cycle control: a double-edged sword
... tion by Hdm2) [9]. L5, L11, and L23 are all components of the large ribosomal 60S subunit. Can subunits of the 40S small subunit also contribute to p53 stabilization and what happens, if processing of the 18S rRNA is ...
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Activated STAT regulates growth and induces competitive interactions independently of Myc, Yorkie, Wingless and ribosome biogenesis
... in ribosome activity between winners and losers appear to be crucial to Myc- and Minute-induced cell competition and may also be required by Myc for its supercompetitor ...of ribosome biogenesis ...
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Up-regulation of ribosome biogenesis by MIR196A2 genetic variation promotes endometriosis development and progression
... genotype for immunofluorescence staining (Figure 4A). We detected total active nucleoli using anti-nucleophosmin (NPM) antibodies, and the dense fibrillar component (DFC), a region with highly active ribosome ...
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Schizosaccharomyces pombe Noc3 Is Essential for Ribosome Biogenesis and Cell Division but Not DNA Replication
... mechanisms that regulate pre-RC assembly and activation us- ing the fission yeast Schizosaccharomyces pombe as a model eukaryotic system. We therefore cloned the fission yeast S. pombe noc3 ⫹ (Spnoc3 ⫹ ) gene and ...
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The Nuclear Export Receptors TbMex67 and TbMtr2 Are Required for Ribosome Biogenesis in Trypanosoma brucei
... in ribosome biogenesis in the parasite Trypanosoma ...bosome biogenesis, including the trypanosome-specific factors P34 and ...aberrant ribosome for- mation, rRNA processing, and polysome ...
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Species Specificity in Ribosome Biogenesis: a Nonconserved Phosphoprotein Is Required for Formation of the Large Ribosomal Subunit in Trypanosoma brucei
... Ribosome biogenesis is a highly conserved process, although differences in rRNA processing are evident in many ...in biogenesis of the 60S subunit, with concurrent defects in processing of the ...
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Therapeutic dosages of aspirin counteract the IL-6 induced pro-tumorigenic effects by slowing down the ribosome biogenesis rate
... of ribosome biogenesis rate may down-regulate p53 proteasomal degradation through the RPs/Mdm2 ...for ribosome building, to bind to Mdm2, thus reducing the Mdm2-mediated proteasomal degradation of ...
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Pfisterer, Iris (2007): The role of the PeBoW-complex in ribosome biogenesis and proliferation of mouse embryonic stem cells. Dissertation, LMU München: Fakultät für Biologie
... functional ribosome biogenesis, a high amount of pre- ribosomal particles is transported into the cytoplasm for their final maturation into ...disturbed ribosome biogenesis, maturation and ...
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Malamoussi, Anastassia (2008): Peter Pan, a new link between ribosome biogenesis and cell cycle control. Dissertation, LMU München: Fakultät für Biologie
... Proteins, which can govern the activity of p53 can also act as tumor suppressors, like p14Arf. p14Arf activates p53 directly by interaction with the negative regulator of p53, Hdm2. Hdm2 plays a pivotal role in ...
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Genetic and Biochemical Interactions Among Yar1, Ltv1 and RpS3 Define Novel Links Between Environmental Stress and Ribosome Biogenesis in Saccharomyces cerevisiae
... cerevisiae, ribosome assembly is linked to environmental conditions by the coordinate transcrip- tional regulation of genes required for ribosome ...the ribosome biogenesis defect of ⌬yar1 ...
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Serial Analysis of Gene Expression Reveals Conserved Links between Protein Kinase A, Ribosome Biogenesis, and Phosphate Metabolism in Ustilago maydis
... Connections between ribosome biogenesis and PKA. Our initial analysis of the SAGE data revealed a potential connec- tion between cAMP signaling, ribosome biogenesis, and trans- lation in U. ...
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Peter Pan functions independently of its role in ribosome biogenesis during early eye and craniofacial cartilage development in Xenopus laevis
... a conserved binding site for the U8 small nucleolar RNA, which has been shown to be involved in rRNA precursor processing (Michot et al., 1999). Injection of PPan MO or ITS2 MO resulted in a significant reduction of 5.8S ...
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Activation of caspases and inhibition of ribosome biogenesis mediate antitumor activity of Chijongdan in A549 non small lung cancer cells
... that ribosome production was enhanced in cancer cells and that ribosome biogenesis played a crucial role in tumor progression ...the ribosome biogenesis related proteins, we conducted ...
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Adjacent Gene Pairing Plays a Role in the Coordinated Expression of Ribosome Biogenesis Genes MPP10 and YJR003C in Saccharomyces cerevisiae
... and ribosome biogenesis (RRB) regulon from Saccharomyces cerevisiae contains some 200 genes, the expression of which is tightly regulated under changing cellular ...
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Impaired Ribosome Biogenesis Disrupts the Integration between Morphogenesis and Nuclear Duplication during the Germination of Aspergillus fumigatus
... in ribosome biogenesis, contributes to the virulence of this fungus by supporting rapid growth at ...affects ribosome biogenesis in ...both ribosome biogenesis and polarized cell ...
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Targeted cancer therapy with ribosome biogenesis inhibitors: a real possibility?
... 80S ribosome particle. In proliferating cells, the ribosome biogenesis rate appears to be regulated by cell proliferation-controlling processes ...of ribosome biogenesis is necessary ...
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