RICH LIPOPROTEINS
Metabolism of apolipoproteins B 48 and B 100 of triglyceride rich lipoproteins in patients with familial dysbetalipoproteinemia
... triglyceride-rich lipoproteins was studied in three adults with familial dysbetalipoproteinemia ...The lipoproteins were labeled with 125I and injected intravenously into fasted ...
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Endothelial HO-1 induction by model TG-rich lipoproteins is regulated through a NOX4-Nrf2 pathway
... TG-rich lipoproteins likely contribute to the development of endothelial dysfunction, albeit via unknown ...TG-rich lipoproteins is regulated through a NOX4-Nrf2 ...
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Characterization of remnants produced during the metabolism of triglyceride rich lipoproteins of blood plasma and intestinal lymph in the rat
... density lipoproteins, all remnants were similar in these ...of lipoproteins, in which a core of nonpolar lipids is covered by a monolayer of polar lipids and ...triglyceride-rich lipoproteins ...
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Influence of lysophosphatidylcholine on the C apolipoprotein content of rat and human triglyceride rich lipoproteins during triglyceride hydrolysis
... hydrolysis with an increase in lysophosphatidylcholine and loss of C-apolipoproteins in both fractions. These inverse changes of lysophosphatidylcholine and C-apolipoproteins during lipid-hydrolysis suggest a causal ...
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Liver heparan sulfate proteoglycans mediate clearance of triglyceride rich lipoproteins independently of LDL receptor family members
... receptors, suggesting that heparan sulfate participates in the clearance of cholesterol-rich lipoproteins as well. Mutant mice synthesized VLDL normally but showed reduced plasma clearance of human VLDL and ...
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ApoC III inhibits clearance of triglyceride rich lipoproteins through LDL family receptors
... ApoC-III–depleted lipoproteins were injected into ...TG-rich lipoproteins primarily through a hepatic clearance mechanism mediated by the LDLR/LRP1 ...
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Syndecan 1 is the primary heparan sulfate proteoglycan mediating hepatic clearance of triglyceride rich lipoproteins in mice
... triglyceride-rich lipoproteins (TRLs) arise from dietary fats in the intestine (chylomicrons) and de novo–synthesized lipids in the liver ...nant lipoproteins arising from LPL-mediated lipolysis are ...
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Triglyceride-rich lipoproteins as a causal factor for cardiovascular disease
... TG-rich lipoproteins (TRLs; ie, very low- density lipoproteins plus chylomicrons) and their ...atherogenic lipoproteins (including LDL, TRL, and TRL remnants), provides a better indication of ...
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Metabolism of triglyceride rich lipoproteins during alimentary lipemia
... triglyceride-rich lipoproteins paralleled the apo B elevations in controls and NTG ...triglyceride-rich lipoproteins in the HTG group was not accompanied by an increase of C ...
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An apolipoprotein E synthetic peptide targets to lipoproteins in plasma and mediates both cellular lipoprotein interactions in vitro and acute clearance of cholesterol rich lipoproteins in vivo
... cholesterol-rich lipoproteins and lipoprotein receptors, an NH2-terminal acetylated apoE dimer peptide was ...with lipoproteins in plasma, whereas nonacylated peptides were poor lipid ...density ...
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Prolonged postprandial responses of lipids and apolipoproteins in triglyceride rich lipoproteins of individuals expressing an apolipoprotein epsilon 4 allele
... the lipoproteins that appear to accumulate to a greater extent in persons with an apo E4/3 phenotype (chylo- micron remnants, VLDL remnants, and LDL) are thought to be atherogenic (36) and may account for the ...
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Secretion of Cholesterol Rich Lipoproteins by Perfused Livers of Hypercholesterolemic Rats
... density lipoproteins (VLDL) and low density lipoproteins (LDL), and a fatty liver which contains cholesterol ester as its major ...cholesterol rich and contains apoE as well as ...
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Distinct murine macrophage receptor pathway for human triglyceride rich lipoproteins
... apolipoprotein (apo)-E, fail to bind to the LDL receptor, yet tryp-VLDL and HTG-VLDL cross- compete for binding to P388D1 macrophage receptors, indicating that these lipoproteins bind to the same sites. The ...
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Apolipoprotein E synthesized by adipocyte and apolipoprotein E carried on lipoproteins modulate adipocyte triglyceride content
... ApoE is a major component of very low density lipopro- teins (VLDL), remnant lipoproteins (RLPs) and high dens- ity lipoproteins (HDL). In the early 1970s, ApoE was firstly discovered as a protein component ...
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Recent progress in the study of brown adipose tissue
... Adipose depots in different parts of the body have unique micromorphology and molecular markers. According to their distinct physiological roles, adipose tissue in mam- mals is categorized into white adipose tissue (WAT) ...
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Increased inflammation, endoplasmic reticulum stress and oxidative stress in endothelial and macrophage cells exacerbate atherosclerosis in ApoCIII transgenic mice
... Since endothelial cells and macrophages play crucial roles in atherosclerosis, we examined whether triglyceride-rich lipoproteins (TRLs), the major lipoproteins, in plasma of ApoCIIItg m[r] ...
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Comparison of the effects of fibrates versus statins on plasma lipoprotein(a) concentrations: a systematic review and meta-analysis of head-to-head randomized controlled trials
... Statins have been shown to modestly decrease Lp(a) levels in individuals with familial hypercholesterolemia [71], but the mechanism of this effect remains elusive. This slight reduction could be explained by the strong ...
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Cell surface heparan sulfate proteoglycans contribute to intracellular lipid accumulation in adipocytes
... The availability of circulating triacylglycerol-rich lipopro- teins for adipocyte utilization and storage relies on transport of these particles across the endothelial barrier. Transcytosis of albumin across ...
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Triglyceride enrichment of HDL enhances in vivo metabolic clearance of HDL apo A I in healthy men
... TG-rich lipoproteins may enhance the lipolytic transformation and subsequent metabolic clearance of HDL particles in hypertriglyceridemic ...into lipoproteins containing apo A-II (LpAI:AII) and those ...
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Association of plasma lipoproteins with postheparin lipase activities
... Studies were designed to explore the association of lipoprotein lipase (LPL) and hepatic triglyceride lipase (HTGL) activities with lipoproteins in human postheparin plasma (PHP). The major peak of LPL activity ...
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