RIG-I-like receptor
RIG-I-Like Receptor and Toll-Like Receptor Signaling Pathways Cause Aberrant Production of Inflammatory Cytokines/Chemokines in a Severe Fever with Thrombocytopenia Syndrome Virus Infection Mouse Model
... type I interferon (IFN-I) receptor 1-deficient (IFNAR1 ⫺/⫺ ) mice have been established as nonlethal and lethal models of SFTSV in- fection, ...gene I (RIG-I)-like ...
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The Z Proteins of Pathogenic but Not Nonpathogenic Arenaviruses Inhibit RIG-i-Like Receptor-Dependent Interferon Production
... inhibits RIG-iN- and MDA5N-induced IFN-  activation in a luciferase (LUC)-based promoter ...-Gal, RIG-iN, or MDA5N plasmids. neg, negative control (no RIG-iN or MDA5N ...the RIG-iN- and ...
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Bothe, Viktoria (2019): Identification and characterization of activators and modulators in the antiviral RIG-I-like receptor pathway. Dissertation, LMU München: Medizinische Fakultät
... that RIG-I is not translocated to MAVS but is always in close surrounding and just needs an activating trigger or that activated RIG-I is not biotinylated because it binds to the CARD domain ...
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Mitophagy Enhances Oncolytic Measles Virus Replication by Mitigating DDX58/RIG-I-Like Receptor Signaling
... The success of future clinical trials with oncolytic viruses depends on the identification and the control of mechanisms that mod- ulate their therapeutic efficacy. In particular, little is known about the role of ...
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Subcellular Localizations of RIG-I, TRIM25, and MAVS Complexes
... The RIG-I-like receptor (RLR) family is composed of cytoplasmic sensors and, to date, three members have been described: RIG-I (retinoic acid-inducible gene 1), MDA5 (melanoma ...
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Porcine Deltacoronavirus Accessory Protein NS6 Antagonizes Interferon Beta Production by Interfering with the Binding of RIG-I/MDA5 to Double-Stranded RNA
... the RIG-I-like receptor (RLR) signaling pathway, specifically RIG-I, MDA5, and their downstream molecules MAVS, TBK1, IKK , and ...by RIG-I/MDA5, resulting in the ...
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C-type lectin receptors and RIG-I-like receptors: new points on the oncogenomics map
... receptors, RIG-I-like receptors, and the proteins of their signaling pathways with various aspects of cancer development may include confounding host, bacterial, or environmental factors in different ...
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RIG I is responsible for activation of type I interferon pathway in Seneca Valley virus infected porcine cells to suppress viral replication
... Toll-like receptor (TLRs), RIG-I-like receptor (RLRs), nucleo- tide oligomerization domain-like receptor (NLRs) and cytosolic DNA sensors [11, ...(LGP2). ...
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The nucleotide binding oligomerization domain containing protein 1 (NOD1) polymorphism S7N does not affect receptor function
... containing receptor (NLR) family needs to be tightly regulated in order to control the inflammatory response to exogenous and endogenous danger ...the RIG-I like ...alter receptor ...
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RIG-1 receptor expression in the pathology of Alzheimer’s disease
... TLRs, RIG-I-like receptors (RLR), NOD-like receptors (NLR), and C-type lectin re- ceptors ...(LGP2). RIG-1 recognizes relatively short dsRNA (up to 1 kb) whereas MDA5 detects long dsRNA ...
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Kirchhofer, Axel (2009): Structural and Functional Analysis of RIG-I Like Helicases -: Modulating Spectral Properties of the Green Fluorescent Protein with Nanobodies. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... of RIG-I RD the 5’-triphosphate interaction site could be mapped to a previously identified positively charged groove, employing structure-guided mutants in RNA binding ...in RIG-I RD are not ...
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The RIG I pathway is involved in peripheral T cell lymphopenia in patients with dermatomyositis
... that RIG-I overexpression and activation by pppRNA could induce apoptosis in T lymphocyte ...Therefore, RIG-I-mediated apoptosis may be one of the possible mechanisms of T cell lymphopenia in ...
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Thogoto Virus Infection Induces Sustained Type I Interferon Responses That Depend on RIG-I-Like Helicase Signaling of Conventional Dendritic Cells
... Mice. MyD88-deficient (MyD88 ⫺/⫺ ) mice were provided by Shizuo Akira (1), TRIF-deficient (TRIF ⫺/⫺ ) mice were from Bruce Beutler (16), and IPS-1-defi- cient (IPS-1 ⫺/⫺ ) mice were provided by Ju ¨rg Tschopp (27). For ...
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Enhanced Influenza Virus-Like Particle Vaccination with a Structurally Optimized RIG-I Agonist as Adjuvant
... costimulatory receptor 4-1BB, major histocom- patibility complex (MHC) class II molecules HLA-DRA and HLA- DQA, and a regulator of antigen presentation, CD74, were all dramatically upregulated by M8 treatment in ...
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Importance of innate mucosal immunity and the promises it holds
... recognition receptor molecules, including toll-like receptors, NOD-like receptors, and RIG-I-like ...recognition receptor molecules recognize various invading pathogens ...
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Gene Expression of Nucleic Acid-Sensing Pattern Recognition Receptors in Children Hospitalized for Respiratory Syncytial Virus-Associated Acute Bronchiolitis
... infected infants, although a trend toward a higher expression of MDA-5, RIG-1, and TLR-8 was observed in infants with HBoV infection compared to that of infants with RV infection. Factors influencing PRR mRNAs ...
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Kinetic discrimination of self/non-self RNA by the ATPase activity of RIG-I and MDA5
... of RIG-I and MDA5 Despite intensive investigations, the mechanism of RIG-I and MDA5 activation remains only partly ...CARD-hel RIG-I reveals an auto-repressed state with the ...
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Sensing of RNA Viruses: a Review of Innate Immune Receptors Involved in Recognizing RNA Virus Invasion
... gene I (RIG-I) contains an ssRNA/dsRNA (ss/dsRNA)-binding C-terminal domain (CTD) which, when unbound, functions as a repressor domain (RD) ...the RIG-I protein contains the DExD/H ...
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Andreeva, Liudmila (2018): Cytosolic DNA sensing via cGAS: long, U-shaped and other DNA ligands and cellular co-factors. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... sensors like NAIP2/NLRC4 inflammasome assembly [617], recognition of structured DNA and cGAS fibril formation might also occur separately in a biological ...context. Like for MDA5 dsRNA receptor ...
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Caenorhabditis elegans RIG I Homolog Mediates Antiviral RNA Interference Downstream of Dicer Dependent Biogenesis of Viral Small Interfering RNAs
... that RIG-I can translocate on long dsRNA powered by ATP hydrolysis (35), a similar translocase activity predicted for DRH-1 (34) would facilitate the rapid translocation of the known DCR-1/RDE-4/DRH-1 ...
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