RNA polymerase II
Interaction of RNA polymerase II and the small RNA machinery affects heterochromatic silencing in Drosophila
... of RNA Polymerase II to centromeric repeats, in dynamic equilibrium with Epe1, which pro- motes transcription ...by RNA Pol II occurs and an increase in the deposition of Ago1, Clr4 and ...
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Transcription of Hepatitis Delta Virus RNA by RNA Polymerase II
... the RNA genome of hepatitis delta virus (HDV) involves redirection of RNA polymerase II (Pol II), a host enzyme that normally uses DNA as a ...HDV RNA transcription, a ...
10
RNA Polymerase II during Transcript Elongation: deaiing with DNA damage and staying phosphorylated
... DNA, RNA polymerase II, RNA, and CSB to recruit TFIIH correlates well with this suggestion ...a polymerase which was stalled by nucleotide omission instead of by a DNA ...eukaryotic ...
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Efficacy of RNA polymerase II inhibitors in targeting dormant leukaemia cells
... We have shown that transcriptional RP2 inhibitors are better able than conventional agents to target dormancy-enriched AML cells. We hypothesised that a therapeutic window might exist for dormant cancer cells because of ...
11
Human Pcf11 enhances degradation of RNA polymerase II-associated nascent RNA and transcriptional termination
... of RNA polymerase II (Pol II) for most eukaryotic protein-coding ...Pol II transcrip- tional termination is the 3’-end processing factor, ...Pol II elongation complexes from ...
10
A Divergent Transcription Factor TFIIB in Trypanosomes Is Required for RNA Polymerase II-Dependent Spliced Leader RNA Transcription and Cell Viability
... SL RNA gene ...SL RNA gene ...Pol II or TbTBP was removed from the extract during the immunodepletion of TbTFIIB ...SL RNA gene promoter ...to RNA Pol II, as robust transcription ...
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Kettenberger, Hubert (2005): Structure of the Complete RNA Polymerase II Elongation Complex and its Interaction with the Elongation Factor TFIIS. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... 10-subunit RNA polymerase II core (Cramer et ...complete polymerase crystals, this crystal form (see Table 8) has a much lower solvent content of around 56 %, and a much larger area of the ...
142
A Role for Histone Chaperones in Regulating RNA Polymerase II
... Transcription is a highly regulated cellular process in which dysfunction leads to disease. One lev- el of regulation is chromatin structure which protects promoters from transcription factor bind- ing. To circumvent ...
10
RNA footprint mapping of RNA polymerase II molecules stalled in the intergenic region of polyomavirus DNA.
... of RNA polymerases be displaced during elongation ...by RNA poly- merase in the intact ...of RNA polymerase II transcribing from the upstream C2 gene ...by RNA polymerase ...
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Bacterial control of host gene expression through RNA polymerase II
... of RNA polymerase II–dependent (Pol II–dependent) host gene ...Pol II–dependent transcription were modified, Pol II phosphorylation was inhibited, and pathogen-specific signaling ...
15
Phosphorylation of Serine 177 of the Small Hepatitis Delta Antigen Regulates Viral Antigenomic RNA Replication by Interacting with the Processive RNA Polymerase II
... with RNA polymerase II (RNAP II), the enzyme assumed to be responsible for antigenomic RNA ...RNAP II (RNAP IIA), which generally binds at the transcription initiation ...RNAP ...
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A Yeast Heterogeneous Nuclear Ribonucleoprotein Complex Associated With RNA Polymerase II
... of RNA polymerase II (pol II) in pre-mRNA ...essential RNA-binding protein that shares homology with mammalian CTD-binding proteins and is thought to regulate mRNA abundance by binding ...
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Expression of RNA virus proteins by RNA polymerase II dependent expression plasmids is hindered at multiple steps
... from RNA viruses by RNA polymerase II (Pol II) dependent cellular promoters might be explained by lack of critical elements required for pre-mRNA stabilisation, mRNA processing and/or ...
10
Mutation of large T-antigen-binding site A, but not site B or C, eliminates stalling by RNA polymerase II in the intergenic region of polyomavirus DNA.
... To determine whether binding of large T antigen to viral DNA is required to block elongation by RNA polymerase II, we examined the level of RNA polymerase stalling on the late strand of [r] ...
10
Compromised RNA polymerase III complex assembly leads to local alterations of intergenic RNA polymerase II transcription in Saccharomyces cerevisiae
... our RNA-Seq data at these loci reveal that the extended 5′-ends observed in tfc6 mutants may normally be con- strained by assembled Pol III complexes that prevent an upstream promoter from acting in a ...
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Armache, Karim (2005): Crystal structures of the complete 12-subunit RNA polymerase II and its subcomplex Rpb4/7, and modeling of RNA polymerases I and III. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... nuclear RNA polymerases, which were discovered between 1965-1970 by Robert Roeder (Roeder and Rutter, 1969a and b, ...1970). RNA Pol I transcribes 18S and 28S rRNA, RNA Pol III snRNAs, tRNAs and ...
126
Post-transcriptional regulation of RNA polymerase II levels in Caenorhabditis elegans.
... ulated: To ask whether control of ama-1 polypeptide synthesis is transcriptional or post-transcriptional, we compared the steady-state levels of ama-1 mRNA from staged cultures[r] ...
9
The positions of TFIIF and TFIIE in the RNA polymerase II transcription preinitiation complex.
... Pol II-TFIIF complex proposed that TFIIF mainly binds to the central cleft and clamp regions of Pol II 24 ...Pol II active site can affect transcriptional start site ...
35
Identification of Kinase Inhibitors that Target Transcription Initiation by RNA Polymerase II
... We further characterized these compounds by analyzing their half maximal inhibitory concentrations (IC50) to measure their individual effectiveness of the drugs towards transcription, specifically using the p21 promoter ...
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The positions of TFIIF and TFIIE in the RNA polymerase II transcription preinitiation complex.
... The four peptide fragments generated by in vitro translation and used for co-immune precipitation with the Tfg2 dimerization domain are listed below.. Blue dots denote the locations of c[r] ...
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