RNA splicing
Cytoplasmic mislocalization of RNA splicing factors and aberrant neuronal gene splicing in TDP-43 transgenic pig brain
... rant RNA splicing was recently found to occur with- out aggregation and loss of nuclear TDP-43 ...abnormal splicing of MNHC II-B in transgenic pig and ALS patient ...
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Kaposi's Sarcoma-Associated Herpesvirus ORF57 Functions as a Viral Splicing Factor and Promotes Expression of Intron-Containing Viral Lytic Genes in Spliceosome-Mediated RNA Splicing
... promotes RNA splicing of K8  pre-mRNAs. Total RNA from HeLa or HEK-293 cells cotransfected as described above was prepared 48 h after transfection and analyzed for K8 by ...on splicing of K8 ...
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RNA processing genes characterize RNA splicing and further stratify lower-grade glioma
... ASEs. RNA splicing activities are governed by RNA processing genes, and our findings showed that worse survival-associated RNA processing genes were most enriched in RNA ...
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Intronic sequences and 3' splice sites control Rous sarcoma virus RNA splicing.
... McNALLY AND BEEMON DISCUSSION We demonstrate with heterologous constructs that the control of RSV RNA splicing involves both cis-acting negative regulatory sequences within the intron of[r] ...
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RBFox1 mediated RNA splicing regulates cardiac hypertrophy and heart failure
... an RNA splicing regulator, RBFox1 (also known as A2BP1), as a prominent regulator of alternative RNA splicing during heart ...of RNA splicing and is required for a conserved ...
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RNA Splicing in a New Rhabdovirus from Culex Mosquitoes
... requires RNA splicing for viral mRNA ...stranded RNA viruses require RNA splicing, which contributes both pro- teomic diversity and regulation of gene expression ...such RNA ...
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Viral Oncogenes, Noncoding RNAs, and RNA Splicing in Human Tumor Viruses
... Viral oncogenes are responsible for oncogenesis resulting from persistent virus infection. Although different human tumor viruses express different viral oncogenes and induce dif- ferent tumors, their oncoproteins often ...
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Alternative RNA splicing: contribution to pain and potential therapeutic strategy
... alternative splicing relating specifically to nociceptive systems was the production of calcitonin gene-related peptide (CGRP) encoded by the calcitonin gene [1], a neuropeptide intimately associated with ...
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RNA Splicing at Human Immunodeficiency Virus Type 1 3′ Splice Site A2 Is Regulated by Binding of hnRNP A/B Proteins to an Exonic Splicing Silencer Element
... of splicing at splice site ...total RNA was isolated from the cells at 48 h after ...primers, RNA was analyzed by RT-PCR for the relative levels of individual mRNAs of both intermediate ...⬃4.0-kb ...
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Hepatitis B virus transcript produced by RNA splicing.
... Lanes: a, end-labeled 4X174 HaeIII fragments; b, end-labeled MspI fragments of pBR322; c, uniformly labeled DNA probe used in Si nuclease analysis; d, end-labeled FspI-BstEII fragment; e[r] ...
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Simian immunodeficiency virus displays complex patterns of RNA splicing.
... Colonies representing the PCR amplification products of the primer pairs PCRAR-PCR25 and PCRSTATPCR25 were initially screened by hybridization with oligonucleotide probes specific for sp[r] ...
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Activation of thermosensitive RNA splicing and production of a heat-labile P85gag-mos kinase by the introduction of a specific deletion in murine sarcoma virus-124 DNA.
... To determine whether thermosensitive splicing is an intrinsic property of MuSVtsllO RNA specified by the 1,487-base deletion or a result of a cellular defect, we examined an "equivalent"[r] ...
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Role of TAR RNA splicing in translational regulation of simian immunodeficiency virus from rhesus macaques.
... The ability of these splicing mutations to reduce the accumulation of both viral RNA and protein as well as the production of cell-free virions is most simply explained by a decrease in [r] ...
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Spliceosomal Proteomics in Trypanosoma brucei Reveal New RNA Splicing Factors
... total RNA from the final eluate and detected the spliceosomal U snRNAs by primer extension assays ...SL RNA and the five U snRNAs copurified with ...total RNA prepared from cell lysates except that ...
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RNA splicing in Borna disease virus, a nonsegmented, negative-strand RNA virus.
... Previous Northern blot analysis of RNA from BDV-infected rat brain tissue has shown that two viral transcripts, a 6.1-kb RNA and a 1.5-kb RNA, lack regions that are internal to two other[r] ...
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Mir-434-5p mediates skin whitening and lightening
... of RNA splicing in this intronic RNAi effect, we further tested three different SpRNAi-RGFP expression systems as shown in Figure 3D: 1, vector expressing intron-free RGFP without any pre-miRNA insert; 2, ...
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SR protein splicing factors interact with the Rous sarcoma virus negative regulator of splicing element.
... full-length RNA must be maintained in an unspliced form, as the unspliced RNA serves both as mRNA for structural proteins and virion-associated enzymatic proteins and as genomic RNA for progeny ...
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Exonic Splicing Enhancer-Dependent Selection of the Bovine Papillomavirus Type 1 Nucleotide 3225 3′ Splice Site Can Be Rescued in a Cell Lacking Splicing Factor ASF/SF2 through Activation of the Phosphatidylinositol 3-Kinase/Akt Pathway
... exonic splicing enhancers, each containing two ASF/SF2 (alternative splicing factor/splicing factor 2) binding sites, are located between the two 3 ⴕ splice sites and have been identified as ...
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Estimation of alternative splicing isoform frequencies from RNA-Seq data
... alternative splicing events, specialized splicing arrays have been developed for genome-wide interrogation of both annotated exons and exon-exon ...by splicing arrays is typically insufficient for ...
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RNA biology of disease-associated microsatellite repeat expansions
... SC-35 splicing speckles after ...SC-35 splicing speckles [274]. RNA containing CAG, CUG and GGGGCC repeats were also shown to localize to SC-35 splicing speckles and nuclear speckles [132, ...
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