Ross River
Effects of an In-Frame Deletion of the 6k Gene Locus from the Genome of Ross River Virus
... The alphaviral 6k gene region encodes the two structural proteins 6K protein and, due to a ribosomal frameshift event, the trans- frame protein (TF). Here, we characterized the role of the 6k proteins in the ...
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Persistence of Multiple Genetic Lineages within Intrahost Populations of Ross River Virus
... We examined the structure and extent of genetic diversity in intrahost populations of Ross River virus (RRV) in samples from six human patients, focusing on the nonstructural (nsP3) and structural (E2) ...
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Chimeric Sindbis-Ross River viruses to study interactions between alphavirus nonstructural and structural regions.
... and Ross River virus are alphaviruses whose nonstructural proteins share 64% identity and whose structural proteins share 48% ...Sindbis-Ross River chimeric viruses in which the structural and ...
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Entry kinetics and mouse virulence of Ross River virus mutants altered in neutralization epitopes.
... of Ross River virus (RRV) by sequencing a number of variants resistant to monoclonal antibody neutralization which were found to have single amino acid substitutions in the E2 protein ...
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A model for the dynamics of Ross River Virus in the Australian environment
... Epidemiologically, Ross River Virus (RRV) is Australia’s most important mosquito- borne disease, causing 4660 (range 1451–9551) human clinical notifications at an estimated economic cost of $15 million ...
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Decreased Virulence of Ross River Virus Harboring a Mutation in the First Cleavage Site of Nonstructural Polyprotein Is Caused by a Novel Mechanism Leading to Increased Production of Interferon Inducing RNAs
... IMPORTANCE This study gives further insight into mechanisms of type I IFN modu- lation by the medically important alphaviruses Ross River virus (RRV) and Sindbis vi- rus (SINV). By characterizing attenuated ...
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Complement Contributes to Inflammatory Tissue Destruction in a Mouse Model of Ross River Virus-Induced Disease
... as Ross River virus (RRV), chikungunya virus, o’nyong-nyong virus, mayaro virus, and others, is a global cause of debilitating musculoskeletal disease (12, ...
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Ross River Virus Glycoprotein-Pseudotyped Retroviruses and Stable Cell Lines for Their Production
... Pseudotyped retroviruses have important applications as vectors for gene transfer and gene therapy and as tools for the study of viral glycoprotein function. Recombinant Moloney murine leukemia virus (Mo-MuLV)- based ...
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Complement Receptor 3 Promotes Severe Ross River Virus-Induced Disease
... as Ross River virus (RRV), chikungunya virus, o’nyong-nyong virus, mayaro virus, and others, are mosquito-transmitted viruses that cause debilitating inflammatory disease in humans (18, 37, ...
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The non human reservoirs of Ross River virus: a systematic review of the evidence
... ‘Ross River virus’ , ‘Ross River fever’ , ‘endemic polyarthritis’ , ‘host’ , ‘reser- voir’ , ‘wild*’ , ‘captive’ , ‘population’ , ‘serolog*’ , ‘serosurvey*’ , ‘anti- bod*’ , ‘virus’ , ‘viral’ ...
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Molecular Genetic Study of the Interaction of Sindbis Virus E2 with Ross River Virus E1 for Virus Budding
... of Ross River virus that is cleaved to an E2/E1 heterodimer and transported to the cell plasma membrane, but this chimeric heterodimer fails to interact with Sindbis virus nucleocapsids, and very little ...
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Applying cusum-based methods for the detection of outbreaks of Ross River virus disease in Western Australia
... Conclusion: Our retrospective analysis of historical data suggests that, compared with the EARS algorithms, the negative binomial cusum provides greater sensitivity for the detection of[r] ...
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In Vivo Gene Transfer Using a Nonprimate Lentiviral Vector Pseudotyped with Ross River Virus Glycoproteins
... Antibody immune responses against -galactosidase and the viral protein p24 were comparable in mice receiving RRV/FIV vector or VSV-G/FIV vector and unrelated to the extent of Kupffer ce[r] ...
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Biological and genetic studies on the E2 glycoprotein of Ross River virus
... xx 4.4 4.5 4.6 4.7 5.1 5.2 5.3 5.4 Neutralization assays of the non-plaque purified, fifth CEF passage virus stocks 109 NB5092 growth in mice injected either subcutaneously or intracereb[r] ...
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Genetic heterogeneity among isolates of Ross River virus from different geographical regions.
... The aim of this study was to use RNase T1 mapping to examine the genetic relatedness of multiple isolates of RR virus from different geographical regions and to determine whether i the v[r] ...
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Attenuating Mutations in nsP1 Reveal Tissue-Specific Mechanisms for Control of Ross River Virus Infection
... R oss River virus (RRV) is a positive-sense, single-stranded RNA virus in the Alphavirus genus of the family Togaviridae (1). RRV is one of a group of related mosquito-transmitted alphavi- ruses, including ...
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Ross River virus and the necessity of multi scale, eco epidemiological analyses
... The distance between a site and the coast was also seen to be an important positive covariate at the suburb and regional spatial resolutions, with more disease further from the coast. This constrasts what is commonly ...
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Genetic and biological studies on laboratory-derived and natural isolates of Ross River virus
... XIII 2.4.5 2.4.6 Compari son of the hydropa thy profile s of E2 of differe nt alphavi ruses Neutra lisation epitope s of RRV T48 and RRV NB5092 67 68 CHAPTER 3: BIOLOGICAL STUDIES ON RR[r] ...
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Differential Induction of Type I Interferon Responses in Myeloid Dendritic Cells by Mosquito and Mammalian-Cell-Derived Alphaviruses
... lines. Ross River virus (T48 strain) was produced from the pRR64 infectious clone (generously provided by Richard Kuhn, Purdue University), which includes the full-length T48 cDNA clone (21) originally iso- ...
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Mutating Conserved Cysteines in the Alphavirus E2 Glycoprotein Causes Virus-Specific Assembly Defects
... There are 80 trimeric, glycoprotein spikes that cover the surface of an alphavirus particle. The spikes, which are composed of three E2 and E1 glycoprotein heterodimers, are responsible for receptor binding and mediating ...
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