Ross River virus
A model for the dynamics of Ross River Virus in the Australian environment
... Epidemiologically, Ross River Virus (RRV) is Australia’s most important mosquito- borne disease, causing 4660 (range 1451–9551) human clinical notifications at an estimated economic cost of $15 ...
20
Specific Ablation of Antiviral Gene Expression in Macrophages by Antibody-Dependent Enhancement of Ross River Virus Infection
... Ross River virus (RRV) is an indigenous Australian arthropod-borne alphavirus responsible for epidemic polyarthritis (EPA), myalgia, and lethargy in ...natural virus receptor and by Fc ...
6
Complement Contributes to Inflammatory Tissue Destruction in a Mouse Model of Ross River Virus-Induced Disease
... as Ross River virus (RRV), chikungunya virus, o’nyong-nyong virus, mayaro virus, and others, is a global cause of debilitating musculoskeletal disease (12, ...chikungunya ...
12
Persistence of Multiple Genetic Lineages within Intrahost Populations of Ross River Virus
... and Ross River) cause fever, rash, and arthritis in humans and are associated with infrequent, but major, outbreaks of disease ...(5). Ross River virus (RRV) infects more than 20 ...
5
Decreased Virulence of Ross River Virus Harboring a Mutation in the First Cleavage Site of Nonstructural Polyprotein Is Caused by a Novel Mechanism Leading to Increased Production of Interferon Inducing RNAs
... IMPORTANCE This study gives further insight into mechanisms of type I IFN modu- lation by the medically important alphaviruses Ross River virus (RRV) and Sindbis vi- rus (SINV). By characterizing ...
15
Complement Receptor 3 Promotes Severe Ross River Virus-Induced Disease
... as Ross River virus (RRV), chikungunya virus, o’nyong-nyong virus, mayaro virus, and others, are mosquito-transmitted viruses that cause debilitating inflammatory disease in ...
10
A Tyrosine-to-Histidine Switch at Position 18 of the Ross River Virus E2 Glycoprotein Is a Determinant of Virus Fitness in Disparate Hosts
... including Ross River virus (RRV), chikungunya virus (CHIKV), o’nyong-nyong virus, and Mayaro virus, are a group of mosquito- transmitted viruses with positive-sense, ...
15
Ross River virus and the necessity of multi scale, eco epidemiological analyses
... Table 3. Relationships and importance of individual covariates in explaining the Ross river virus infection count per area across three spatial scales. Vector abundance and (Shannon) diversity of ...
33
The non human reservoirs of Ross River virus: a systematic review of the evidence
... ‘Ross River virus’ , ‘Ross River fever’ , ‘endemic polyarthritis’ , ‘host’ , ‘reser- voir’ , ‘wild*’ , ‘captive’ , ‘population’ , ‘serolog*’ , ‘serosurvey*’ , ‘anti- bod*’ , ...
13
Adaptive Mutations in Sindbis Virus E2 and Ross River Virus E1 That Allow Efficient Budding of Chimeric Viruses
... from Ross River virus (RR) and the rest of the genome was derived from Sindbis virus (SIN), was almost nonviable because of a defect in budding ...in virus formation (12, 14, 16, 44), ...
8
An Amino Acid Substitution in the Coding Region of the E2 Glycoprotein Adapts Ross River Virus To Utilize Heparan Sulfate as an Attachment Moiety
... of Ross River virus strain NB5092 in avian cells has been previously shown to select for virus variants that have enhanced replication in these ...effect. Ross River virus ...
7
Molecular Genetic Study of the Interaction of Sindbis Virus E2 with Ross River Virus E1 for Virus Budding
... Sindbis virus will form a heterodimer with glycoprotein E1 of Ross River virus that is cleaved to an E2/E1 heterodimer and transported to the cell plasma membrane, but this chimeric ...
6
Characterization of Ross River Virus Tropism and Virus-Induced Inflammation in a Mouse Model of Viral Arthritis and Myositis
... infectious virus was detectable in the ankle joints of RRV-infected mice by plaque assay by 12 hpi; however, infec- tious RRV has not yet been recovered from the joints of RRV-infected patients ...with Ross ...
13
Effects of an In-Frame Deletion of the 6k Gene Locus from the Genome of Ross River Virus
... alphavirus Ross River virus (RRV) in infected cells and in mice, using a novel 6k in-frame deletion ...corresponding virus had increased sensitivity to a higher ...wild-type virus, with ...
10
Entry kinetics and mouse virulence of Ross River virus mutants altered in neutralization epitopes.
... of Ross River virus (RRV) by sequencing a number of variants resistant to monoclonal antibody neutralization which were found to have single amino acid substitutions in the E2 protein ...
6
Attenuating Mutations in nsP1 Reveal Tissue-Specific Mechanisms for Control of Ross River Virus Infection
... of virus RNA and/or antigen in musculoskeletal tis- sues (21, 22), (iii) mononuclear inflammatory infiltrates in joints and muscle tissue (19, 22–24), and (iv) disease signs, such as mus- culoskeletal pain and ...
14
Genetic heterogeneity among isolates of Ross River virus from different geographical regions.
... The aim of this study was to use RNase T1 mapping to examine the genetic relatedness of multiple isolates of RR virus from different geographical regions and to determine whether i the v[r] ...
10
Mosquito excreta: a sample type with many potential applications for the investigation of Ross River virus and West Nile virus ecology
... high virus concentration [50]. Studies to test Japanese encephalitis virus (JEV) vaccines using Rhesus macaques exposed intranasally to JEV required at least ...viable virus in excreta would be even ...
18
In Vivo Gene Transfer Using a Nonprimate Lentiviral Vector Pseudotyped with Ross River Virus Glycoproteins
... Forest virus, and Sindbis virus all belong to the alphavirus family, they appear to utilize different cellular molecules as receptors for cell binding and/or ...bis virus to cells ...bis ...
11
Ross River Virus Envelope Glycans Contribute to Type I Interferon Production in Myeloid Dendritic Cells
... Additional virus inactivation by UV light (as de- scribed above) was performed prior to titration by twofold serial dilutions across the ...encephalomyocarditis virus was added to each well at an MOI of ...
10