RRM domain
The structure and selectivity of the SR protein SRSF2 RRM domain with RNA
... The structure of SRSF2 RRM domain comprises a four strand anti-parallel b-sheet and two a-helices. The highly ordered secondary structure elements are apparent in the ensemble of structures (Figure 1B) with ...
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Function of RRM Domains of Drosophila melanogaster ELAV: RNP1 Mutations and RRM Domain Replacements With ELAV Family Proteins and SXL
... the domain structure as follows: A, Ala- and Gln-rich amino-terminal domain; 1, RRM1; 2, RRM2; h, hinge domain; and 3, ...The RRM ribbon structure of U1A protein (Nagai et ...of domain ...
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The Arabidopsis RRM domain protein EDM3 mediates race specific disease resistance by controlling H3K9me2 dependent alternative polyadenylation of RPP7 immune receptor transcripts
... EDM2 promotes high levels of H3K9me2 at a transposon-associated proximal polyadenylation site in the first RPP7 intron and suppresses its use, thereby repressing a non-coding transcript [r] ...
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Unification of Cas protein families and a simple scenario for the origin and evolution of CRISPR-Cas systems
... single RRM domain with structural embellishments along with (in some of the Cas7 proteins) a Zn-finger domain, and so resemble polymerases in their domain ...another RRM-domain ...
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RNA-Binding Domain Proteins in Kinetoplastids: a Comparative Analysis
... The minimal set of RRM proteins. Our results with the three kinetoplastids had revealed 12 RRM proteins which had clearly been conserved from kinetoplastids to yeast or mam- mals (Table 2). These were two ...
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RRM adjacent TARDBP mutations disrupt RNA binding and enhance TDP-43 proteinopathy
... RRM1 domain in a father and son with ALS and ALS/FTD. RRM domains show marked evolutionary conservation and variation largely absent from human genome ...either RRM domain, will abolish RNA ...
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Structural basis of nucleic acid binding by Nicotiana tabacum glycine-rich RNA-binding protein: implications for its RNA chaperone function
... NtRRM domain is a canonical RRM domain that binds a CTG/CUG containing nucleic acid with low micromolar affinity and short complex ...the RRM domain also binds other RNA sequences with ...
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Translocation of Tomato Bushy Stunt Virus P19 Protein into the Nucleus by ALY Proteins Compromises Its Silencing Suppressor Activity
... N-terminal domain (amino acids [aa] 1 to 100); a central, RNA recognition motif (RRM) domain (aa 101 to 195 of AtALY2; aa 101 to 191 of AtALY3); and a C-terminal domain (aa 196 to 292 of ...
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Identification of charged amino acids required for nuclear localization of human L1 ORF1 protein
... the RRM and CTD that are conserved between mouse and human ORF1 proteins ...the RRM domain of a WT ORF1p into alanines to determine the effects of accumulated mutations ...
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Multifunctional G-Rich and RRM-Containing Domains of TbRGG2 Perform Separate yet Essential Functions in Trypanosome RNA Editing
... or RRM add-back cell ...the RRM line contained no live ...G-rich domain performs a critical function and that the RRM domain is required to facilitate or complement the G-rich region’s ...
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The structural characterisation of two DNA protectants during stress; the tandem RRM domains of mouse TDP-43 and E.coli DPS
... TAR DNA Binding protein (TDP-43) is a member of the heterogeneous nuclear ribonucleoprotein family with crucial splicing, transport and regulatory function of genetic material inside mammalian cells. Unfortunately, ...
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5G innovations for new business opportunities
... The 5G concept developed in this paper is not limited to the RAN; it covers the end-to-end path and allows the 5G network to act as a secure, reliable and flexible orchestration platform across multiple domains. The 5G ...
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Channel Optimisation and Interference Mitiqation Techniques for Advanced Cellular Mobile Communication
... Radio Resource Management In cellular networks, RRM functionalities include the partitioning of the available spectrum between base stations macro cells and small cells, resource allocat[r] ...
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A design study of VOR: A versatile optimal resolution chopper spectrometer for the ESS
... The fluxes expected on VOR are given in Fig. 7. The results are compared to flux data provided by CNCS at the SNS [3] and LET [1] at ISIS. The VOR Chopper Spectrometer can offer a ten-fold increase in flux at equivalent ...
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Evaluation of MGIT 960 Based Antimicrobial Testing and Determination of Critical Concentrations of First and Second Line Antimicrobial Drugs with Drug Resistant Clinical Strains of Mycobacterium tuberculosis
... by RRM. Since the RRM results are recorded after 4 weeks of growth, the time window allows not only the dominant susceptible population to be detected, but also the mutant subpopulation of ...
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Recent advances in radio resource management for heterogeneous LTE/LTE-A networks
... an RRM scheme is proposed based on a repeated game theory approach for LTE-A multihop ...this RRM scheme, the available PRBs are partitioned statically among the BSs ...
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RNA Recognition Motif (RRM) of La/SSB: The Bridge for Interparticle Spreading of Autoimmune Response to U1-RNP
... their RRM motifs (in the case of La/SSB, RNP-A and RNP-70 autoantigens) (2), molecular similarity of conserved se- quences within RRM could be involved in the intermolecular and ...
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Journal of Computer Networks
... This paper bridges the gap of knowledge about performance of RRM switches by developing its mathematical model which provides theoretical foundation for RRM switch analysis. Theoretical analysis of maximum ...
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Cosic’s Resonance Recognition Model for Protein Sequences and Photon Emission Differentiates Lethal and Non Lethal Ebola Strains: Implications for Treatment
... Cosic RRM are the equivalent of the molecular structure or a type of “virtual” structure, the IR should produce a non-lethal representation within the viral pro- ...
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BG-12 and its potential for the prevention of relapse in multiple sclerosis
... The first Phase III study, DEFINE (Determination of the Efficacy and safety of oral Fumarate IN rElapsing-remitting MS), enrolled 1,237 subjects with McDonald-defined RRM[r] ...
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