S100A8/S100A9
Inflammation and pancreatic cancer: molecular and functional interactions between S100A8, S100A9, NT-S100A8 and TGFβ1
... products, S100A8 resulted in a series of low mo- lecular weight peptides, which were more abundant at 2280 ...original S100A8 protein, this being five aa longer than the PDAC-associated NT-S100A8 ...
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Autoinhibitory regulation of S100A8/S100A9 alarmin activity locally restricts sterile inflammation
... diseases. S100A8/S100A9 are the most abundant alarmins in many clinically relevant disorders, such as rheuma- toid arthritis or other autoimmune diseases, inflammatory lung or bowel diseases, allergies, or ...
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S100A9 regulates cisplatin chemosensitivity of squamous cervical cancer cells and related mechanism
... 9. Korndörfer IP, Brueckner F, Skerra A. The crystal structure of the human (S100A8/S100A9)2 heterotetramer, calprotectin, illustrates how con- formational changes of interacting alpha-helices can ...
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S100A9 protein is a novel ligand for the CD85j receptor and its interaction is implicated in the control of HIV 1 replication by NK cells
... and S100A8/S100A9 complexes were almost ex- clusively expressed by p24- MDDC and were up regulated and down regulated respectively on p24- MDDC during the course of a productive HIV-1 infection (Figure 3, ...
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Amyloid-β peptide-induced extracellular S100A9 depletion is associated with decrease of antimicrobial peptide activity in human THP-1 monocytes
... S100A8, S100A9 and S100A12, as endogenous pro- teins associated with inflammation, are proposed to act as damage-associated molecular pattern (DAMP) initia- tors of innate immunity ...[29]. ...
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Decreases in serum levels of S100A8/9 (calprotectin) correlate with improvements in total swollen joint count in patients with recent onset rheumatoid arthritis
... of S100A8/9 measured in our study were higher, which can be explained by the use of various antibodies to detect different epitopes in differ- ent ...on S100A8/ S100A9 heterocomplex formation and ...
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S100A8/A9 increases the mobilization of pro inflammatory Ly6Chigh monocytes to the synovium during experimental osteoarthritis
... including S100A8 and S100A9, were mea- sured in the synovium and BM cells isolated from the contralateral ...for S100A8, S100A9 and ...
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S100A8/A9, a potent serum and molecular imaging biomarker for synovial inflammation and joint destruction in seronegative experimental arthritis
... serum S100A8/A9 has been widely accepted as a powerful serum biomarker to assess disease activity and to predict therapy response [8], its role as a serum biomarker in seronegative arthritis is still under ...
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Increased proinflammatory endothelial response to S100A8/A9 after preactivation through advanced glycation end products
... with S100A8/S100A9, however, a marked dif- ference was seen between AGE prestimulated and control cells, as only HUVEC sensitized by AGEs showed a signif- icant proinflammatory response, evidenced by ...
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S100A8 and S100A9 in experimental osteoarthritis
... by S100A8, S100A9, or the heterocomplex, gene expression in all cultures including controls was subsequently cor- rected for total RNA [22] and the effect of added S100 proteins expressed as fold change ...
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Expression of S100A8 correlates with inflammatory lung disease in congenic mice deficient of the cystic fibrosis transmembrane conductance regulator
... of S100A9 was not investigated, the results suggested that CF pathology relates to abnormal regulation of the immune ...of S100A8 between individual G551D CF lungs, and since these mice were of a mixed ...
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Fcγ receptor mediated influx of S100A8/A9 producing neutrophils as inducer of bone erosion during antigen induced arthritis
... alarmin S100A8/A9, which has been shown to directly in- duce osteoclast activity in vitro via TLR4 signaling ...of S100A8 coinciding with lower neutrophil numbers in the joints of Fc γ RI,II,III,IV − / − ...
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S100A8 inhibits PDGF-induced proliferation of airway smooth muscle cells dependent on the receptor for advanced glycation end-products
... of S100A8 to RAGE in a variety of cell lines [18, 30]. The S100A8 pro- tein has been reported to promote tumor cell growth [18], to mediate endotoxin-induced cardiomyocyte dys- function [30], to activate NK ...
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Visualization of Tumor-Immune Interaction - Target-Specific Imaging of S100A8/A9 Reveals Pre-Metastatic Niche Establishment
... for S100A8/A9 in priming organs such as the brain and lung, for metastastic predisposition, has been demonstrated in murine breast cancer models ...revealed S100A8/A9 as marker of poor prognosis ...
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Visualization of Tumor-Immune Interaction - Target-Specific Imaging of S100A8/A9 Reveals Pre-Metastatic Niche Establishment.
... an S100A9-specific antibody labeled with Indium-111 (In-111) in ...systemically. S100A9-specific SPECT imaging showed a higher tracer uptake in lungs, spleen and tumor of mice, implanted with metastatic ...
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High expression of <em>S100A8</em> gene is associated with drug resistance to etoposide and poor prognosis in acute myeloid leukemia through influencing the apoptosis pathway
... of S100A8 mRNAs (GenBank No: NM_002964.4). The sense primer for S100A8 was 5 ′ -CCGAGTGTCCTCAGTATATCAGGA-3 ′ and the anti- sense primer 5 ′ -GCCCATCTTTATCACCAGAATGA-3 ′ ...assays. S100A8 ...
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Tumor microenvironment-derived S100A8/A9 is a novel prognostic biomarker for advanced melanoma patients and during immunotherapy with anti-PD-1 antibodies
... protein S100A8/A9 in melan- oma tissue and analyzed the prognostic and predictive value of serum S100A8/A9 for metastatic melanoma pa- tients and in the setting of immune-checkpoint inhibitor ...that ...
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Predictive value of serum calprotectin (S100A8/A9) for clinical response after starting or tapering anti TNF treatment in patients with rheumatoid arthritis
... Objectives calprotectin (S100a8/a9) has been correlated with disease activity in rheumatoid arthritis (ra). the aim of this study was to investigate the predictive value of serum calprotectin for clinical response ...
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Calprotectin (S100A8/A9) has the strongest association with ultrasound detected synovitis and predicts response to biologic treatment: results from a longitudinal study of patients with established rheumatoid arthritis
... proteins S100A8 and S100A9 (also called myeloid-related protein 8 [ MRP8 ] and MRP14 ), found mainly in circulating neu- trophils and monocytes and in macrophages in RA syn- ovial tissue [3, ...
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The S100A8/A9 heterodimer amplifies proinflammatory cytokine production by macrophages via activation of nuclear factor kappa B and p38 mitogen activated protein kinase in rheumatoid arthritis
... and S100A9 are secreted as complexes from neu- trophils and monocytes after activation of protein kinase C in a novel pathway requiring an intact microtubule network ...The S100A8/A9 heterodimer, originally ...
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