Sabin vaccine
Determinants of attenuation and temperature sensitivity in the type 1 poliovirus Sabin vaccine.
... 1 Sabin vaccine strain, a series of recombinant viruses were constructed by using infectious cDNA clones of the virulent type 1 poliovirus P1/Mahoney and the attenuated type 1 vaccine strain ...
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Evolution of the Sabin Vaccine into Pathogenic Derivatives without Appreciable Changes in Antigenic Properties: Need for Improvement of Current Poliovirus Surveillance
... A type 2 poliovirus, BLR-319-07-28 (hereinafter referred to as PV2/Bel), was isolated from stools of 3-year-old boy, an inhabitant of the Gomel region, Belarus, collected on May 2007 on day 6 after the onset of acute ...
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Sabin Vaccine Reversion in the Field: a Comprehensive Analysis of Sabin-Like Poliovirus Isolates in Nigeria
... their vaccine history, where the probability of acquiring infection from vac- cination is given by equation 9 of reference ...for vaccine take in Nigerian AFP cases relative to that in healthy trial ...
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An antigen chimera of poliovirus induces antibodies against human papillomavirus type 16.
... The fact that the modified chimeric viruses exhibit dual antigenicity and immunogenicity led us to explore the possibility of using the Sabin vaccine strain of poliovirus type 1 as a vec[r] ...
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Genotype specific RNA probes for direct identification of wild polioviruses by blot hybridization
... three Sabin vaccine strain-specific probes (Sab1/VP1, Sab2/ VP1, and Sab3/VP1 [referred to here as Sab1, Sab2, and Sab3, respectively]) (6), and the four wild genotype-specific probes (Ande1, Braz1, Braz3, ...
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Direct Detection of Sabin Poliovirus Vaccine Strains in Stool Specimens of First Dose Vaccinees by a Sensitive Reverse Transcription PCR Method
... Orimune vaccine reported an increased fre- quency of occurrence of PV revertants and an increased du- ration of virus excretion in the stools of vaccinees who were immunized with IPV followed by OPV compared to ...
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The human hookworm vaccine
... Hookworm Vaccine is ...hookworm vaccine, the Sabin Vaccine Institute is partnering with public sector vaccine manufacturers in so-called innovative developing countries (IDCs) such as ...
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Mapping of attenuating sequences of an avirulent poliovirus type 2 strain.
... When the 5' noncoding region of the type 3 Sabin vaccine strain, known to carry a strong attenuating mutation at base 472, was substituted for that of P2/Lansing, the recombinant was dra[r] ...
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Long-Term Circulation of Vaccine-Derived Poliovirus That Causes Paralytic Disease
... the Sabin vaccine strain isolated in a case of paralytic poliomyelitis from a 7-month-old immunocompetent baby in an apparently adequately immunized ...1) vaccine-derived ...their vaccine ...
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Molecular and Antigenic Characterization of a Highly Evolved Derivative of the Type 2 Oral Poliovaccine Strain Isolated from Sewage in Israel
... and vaccine- derived polioviruses (4, 5, 11, 12, 15; ...the Sabin vaccine strains upon administration of oral poliovaccine (OPV) are frequently associated with reversion of the attenuated pheno- type ...
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Modulation of humoral response to a 12-amino-acid site on the poliovirus virion.
... Several strains of the virus including the Sabin vaccine strains of all three serotypes and the parental neurovirulent strains of poliovirus 1 [Mahoney] and poliovirus 3 [Leon] have been[r] ...
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Detection of Emerging Vaccine Related Polioviruses by Deep Sequencing
... RNA extraction and DNA generation. RNA was extracted from frozen stool samples on a QIAcube instrument using the RNeasy minikit (both from Qiagen, Germantown, MD) according to the manufac- turer’s instructions. Five ...
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viruses-07-02894.pdf
... and Sabin variants (Figure ...the Sabin I ...the Sabin I polymerase, keeping in mind that other mutations in the Sabin I virus may have also played a role in regards to the polymerase changes ...
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Nucleotide variation in Sabin type 3 poliovirus from an Albanian infant with agammaglobulinemia and vaccine associated poliomyelitis
... as vaccine-related isolates having >1 % nucleotide divergence from the cor- responding type 3 or type 1 Sabin strain in the genome coding for the major capsid surface protein, VP1 (or ...
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Multiplex PCR based titration (MPBT) assay for determination of infectious titers of the three Sabin strains of live poliovirus vaccine
... poliovirus vaccine (OPV), which stimulates robust systemic and mucosal immunity [2] and serves to immunize close contacts as well as vacci- nees ...of Sabin strains in stools; those ...
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Antigenic Evolution of Vaccine-Derived Polioviruses: Changes in Individual Epitopes and Relative Stability of the Overall Immunological Properties
... The Sabin oral poliovirus vaccine (OPV) readily undergoes changes in antigenic sites upon replication in ...original vaccine, small changes, if any, in the neutralizing capacity of human or rabbit ...
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Cohesive fracture analysis using Powell-Sabin B-splines
... Powell-Sabin B-splines, which are based on triangles, are employed to model cohesive crack propagation without a predefined interface. The method removes limitations that adhere to isogeometric analysis regarding ...
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Genomic Features of Intertypic Recombinant Sabin Poliovirus Strains Excreted by Primary Vaccinees
... single Sabin 1 pattern (not ...of Sabin 1 and Sabin 3 patterns ...original Sabin 1 strain and a recombinant genome ...the Sabin 1 HinfI restriction site at nucleotide position 5980 ...
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Direct agglutination test for diagnosis of Toxoplasma infection: method for increasing sensitivity and specificity
... A method that increases the sensitivity and specificity of the direct agglutination AG test for diagnosis of Toxoplasma gondii infection is described.. Qualitative results in the Sabin-F[r] ...
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Scattered data fitting on surfaces using projected Powell-Sabin splines
... Sabin macro-element to solve the interpolation problem in the tangent plane. Its key feature is that it is constructed from only nine pieces of data, the values and gradients at the three vertices of the ...
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