Salmonella vaccine
Oral vaccination with a recombinant Salmonella vaccine vector provokes systemic HIV 1 subtype C Gag specific CD4+ Th1 and Th2 cell immune responses in mice
... live Salmonella enterica serov- arTyphimurium vaccine vector in mice after oral immuni- ...in Salmonella was improved when the gene was codon-optimized confirm- ing published data ...in ...
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An oral recombinant Salmonella enterica serovar Typhimurium mutant elicits systemic antigen-specific CD8+ T cell cytokine responses in mice
... recombinant Salmonella vaccine vector was constructed A prokaryotic expression cassette was developed in which the gfp gene was fused in-frame with an E coli β -galactosi- dase α -fragment sequence ...
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Oral Immunization with Attenuated Salmonella enterica Serovar Typhimurium Encoding Cryptosporidium parvum Cp23 and Cp40 Antigens Induces a Specific Immune Response in Mice
... different vaccine formulations by different routes was far more immunogenic, significantly boosting Cp23 and Cp40 serum IgG ...evaluated Salmonella vaccine strain SK100 (17) expressing Cp23 antigen ...
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Evaluation of Regulated Delayed Attenuation Strategies for Salmonella enterica Serovar Typhi Vaccine Vectors in Neonatal and Infant Mice
... for Salmonella vaccine ...attenuated Salmonella enterica serovar Typhi and Salmonella enterica serovar Typhimu- rium vaccine vectors with similar genetic backgrounds in vitro and in ...
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Antibody titers in turkeys increase after multiple booster vaccinations with an attenuated Salmonella live vaccine
... a Salmonella strain present in the caecum is associ- ated with the antibody-response and the protectiveness against infection with virulent strains, although the antibody response might not be the cause of protec- ...
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Efficacy of a Salmonella live vaccine for turkeys in different age groups and antibody response of vaccinated and non vaccinated turkeys
... about Salmonella infections in turkeys are still scarce, although certain aspects of the humoral immune response have been studied before ...live Salmonella vaccine for its ability to induce primary ...
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Animal Models for Salmonellosis: Applications in Vaccine Research
... certain Salmonella serovars to readily infect ...candidate vaccine and/or predict how a potential vaccine may perform in ...on Salmonella clinical syndromes and pathogenesis and then summarize ...
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Analysis of Spleen Induced Fimbria Production in Recombinant Attenuated Salmonella enterica Serovar Typhimurium Vaccine Strains
... a Salmonella vaccine strain to deliver a guest ...attenuated vaccine strains, 9088, to delete three fimbrial operons while the fourth operon was constitutively ...in Salmonella virulence and ...
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Regulated Delayed Shigella flexneri 2a O-antigen Synthesis in Live Recombinant Salmonella enterica Serovar Typhimurium Induces Comparable Levels of Protective Immune Responses with Constitutive Antigen Synthesis System
... attenuated Salmonella strains. However, a hybrid E.coli vaccine failed to protect Shigella infection in humans because it had no capacity to invade epithelial cells and showed only weak protection even with ...
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PREPARATION AND EVALUATION OF CHEMICALLY INACTIVATED SALMONELLA ENTERITIDIS VACCINE IN CHICKENS
... killed Salmonella vaccine has the ability to stimulate beneficial antibody ...attenuated vaccine is able to induce mucosal, cellular immune responses in chickens ...
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A DNA Vaccine versus Attenuated Vaccine to Protect against Salmonella Infection in Chickens
... DNA vaccine containing Salmonella genomic DNA encapsulated in a liposome as a vector and a live attenuated Salmonella vaccine comprising 5 attenuated Salmonella serovars that were ...
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Protective immunity against Trichinella spiralis in mice elicited by oral vaccination with attenuated Salmonella-delivered TsSP1.2 DNA
... attenuated Salmonella, the sIgA has crucial roles for expelling or sacrificing intestinal parasites ...typhimurium vaccine showed protection against ...attenuated Salmonella carrying ...attenuated ...
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Salmonella Typhi-specific multifunctional CD8+ T cells play a dominant role in protection from typhoid fever in humans.
... for Salmonella Typhi from day 5 post-challenge or, oral temperature ≥38 °C, persisting continuously for at least 12-h in the absence of anti-pyretic medica- tion, occurring from 72-h after ...
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Importance of Salmonella Typhi-Responsive CD8+ T Cell Immunity in a Human Typhoid Fever Challenge Model
... Since very few data are available on the baseline immune responses in the context of typhoid fever, the reasons for the dis- parity observed between baseline responses against S. Typhi and clinical outcome between the ...
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Oral infection with the Salmonella enterica serovar Gallinarum 9R attenuated live vaccine as a model to characterise immunity to fowl typhoid in the chicken
... 9R vaccine strain developed in the 1950s, has a 'semi-rough' lipopolysaccharide structure, but the nature of its attenuation is not known ...9R vaccine strain still results in systemic dis- ease with ...
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Natural and vaccine-mediated immunity to Salmonella Typhimurium is impaired by the helminth Nippostrongylus brasiliensis
... bacterium, Salmonella Typhimurium against which we have also developed an experimental porin vaccine, and the second is an invasive helminth, Nippostrongylus brasiliensis, that models aspects of hookworm ...
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Why the development of effective typhoid control measures requires the use of human challenge studies.
... Salmonella Typhi (S. Typhi) has affected mankind for the last 50,000 years (Kidgell et al., 2002; Roumagnac et al., 2006), how- ever the precise pathogenesis in humans has largely remained a mystery (Crump and ...
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T- and B-Cell Immune Responses of Patients Who Had Undergone Colectomies to Oral Administration of Salmonella enterica Serovar Typhi Ty21a Vaccine
... Ty21a vaccine. Similar frequencies of Salmonella IgA antibody responses in the jejunal fluids of healthy volunteers after oral immunization with the same and other derivatives of Ty21a vaccine have ...
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IgG Responses to Porins and Lipopolysaccharide within an Outer Membrane Based Vaccine against Nontyphoidal Salmonella Develop at Discordant Rates
... A single Gram-negative bacterium can contain millions of LPS molecules (41), and each O-Ag can contain over a hundred repeats (42), although in GMMA, estimates suggest that numbers of O-Ag repeats are lower than in WT ...
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Not All Antigens Are Created Equally: Progress, Challenges, and Lessons Associated with Developing a Vaccine for Leishmaniasis
... Besides traditional recombinant expression approaches, many antigens have also been investigated in DNA vaccines (20). VL patients possess antibodies against the hemoglobin receptor (HbR) of Leishmania, and this protein ...
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