SARS-CoV main protease
Virtual screening of potential inhibitors for SARS-CoV-2 main protease
... of SARS-CoV-2 pandemic, several efforts have been done to identify pharmacological agents that inhibit the virus entry, avoid the virus replication or blocks the assembly of new viruses ...confirmed ...
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Potential of Plant Bioactive Compounds as SARS-CoV-2 Main Protease (M pro ) and Spike (S) Glycoprotein Inhibitors: A Molecular Docking Study
... The major flavanone glycoside in the citrus peel is hesperidin [77]. Docking scores of this compound with S protein and M pro were -10.4 and -8.3, respectively. Utomo et al. [78] have docked hesperidin against S protein ...
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Virtual Screening of Approved Clinic Drugs with Main Protease (3CLpro) Reveals Potential Inhibitory Effects on SARS-CoV-2
... By using high-throughput virtual screening, 23 approved drugs with binding energy below -11kcal / mol were obtained as candidate drugs (Fig. 1). The result included 7 peptides or peptide analogs and 17 small molecule ...
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ZINC44018332, ZINC2101723, ZINC2094526, ZINC2094304, ZINC2104482, ZINC3984030,
... The SARS-CoV-2 ORF1ab code for polyprotein 1ab (pp1ab) is where the main protease Mpro is found, which is similar to a key enzyme in the processing of the picornavirus family ...The ...
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The Papain-Like Protease from the Severe Acute Respiratory Syndrome Coronavirus Is a Deubiquitinating Enzyme
... (34). SARS, which emerged in China in late 2002, is a pulmonary infection with a reported fatal outcome of 10% ...The SARS coronavirus (SARS-CoV) is an envel- oped, single-stranded ...
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Virtual Screening based prediction of potential drugs for COVID-19
... SARS-CoV-2 is the betacoronavirus responsible for the COVID-19 pandemic. It was listed as a potential global health threat by WHO due to high mortality, high basic reproduction number and lack of clinically ...
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Journal_of_Virology-2018-Zheng-e01504-18.full.pdf
... (MERS- CoV) as the model ...lysosomal protease activities from different host species and tissue cells are an important determinant of the species and tissue tropism of ...of SARS and MERS ...
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Investigating Potential Inhibitory Effect of Uncaria tomentosa (Cat`s claw) against the Main Protease 3CL Pro of SARS-CoV-2 by Molecular Modeling
... The 2019 novel coronavirus (2019-nCoV) known also as the severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) is a part of Coronavirus Family (CoV) and was initially identified in Wuhan, ...
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Potential inhibitors of SARS-CoV-2 Main protease (M pro ) identified from the library of FDA approved drugs using molecular docking studies
... Corona Virus Infectious Disease-2019 (COVID-19) outbreak originated recently at Wuhan, China in December 2019. It has already spread rapidly to more than 200 countries and has been declared a pandemic by WHO. It is ...
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An insilico study to identify hidden features of Spike protein and Main protease of SARS-Cov2
... This domain shows higher number of cysteine which are positionally conserved. It forms a beta- sandwich by two sheets with parallel and antiparallel strands. These domains are possibly involved in adhesion and ...
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High throughput virtual screening to discover inhibitors of the main protease of the coronavirus SARS-CoV-2
... SARS-CoV-3 main protease, which would explain the age divide in terms of COVID-19 ...against SARS-CoV-2 ...that SARS-CoV-2 uses for host entry and which in ...
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High throughput virtual screening to discover inhibitors of the main protease of the coronavirus SARS-CoV-2
... In late 2019, COVID-19, another member of the Coronaviridae family previously unknown was identified and implicated in a global epidemic of respiratory systems. On March 11 th 2020, the World Health Organization (WHO) ...
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Identification of Pharmacophoric features and novel compounds for inhibition of SARS-Cov-2 Main Protease
... the SARS- CoV-2 or ...of SARS CoV-2 being related to SARS have been proved by their phylogenetic studies and can be correlated for the research and development of novel antiviral drugs ...
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The main protease of SARS-CoV-2 as therapeutic target to development specific drugs to treat COVID-19
... serine protease 2 (TMPRSS2) are responsible for the attachment to the angiotensin-converting enzyme 2 (ACE2) receptor and entry into the cell targets ...serine protease hydrolyzes specific peptide bonds in ...
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Variable Structural Networks at the Active Site of the SARS-CoV and SARS-CoV2 Main Proteases
... coronavirus, SARS-CoV2 (CoV2), constituted a ...with SARS-CoV (CoV) that was identified in 2003 [3,4]. CoV is highly dependent on the main protease (M pro , or 3C-Like ...
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Supplementary Materials: High throughput virtual screening to discover inhibitors of the main protease of the coronavirus SARS-CoV-2
... Figure S1: Chemical fragments majorly featured in the top performing 9,515 synthetic com- pounds obtained from screening against the crystal structure of the SARS-CoV-2 main pro- tease 3[r] ...
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Quantitative Proteomics Analysis Reveals BAG3 as a Potential Target To Suppress Severe Acute Respiratory Syndrome Coronavirus Replication
... with SARS-CoV and the coronavirus mouse hepatitis virus (MHV) could be autophagosomes, while MHV infection appears to induce autophagy and inhibition of autophagy leads to sup- pression of MHV growth (52, ...
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0096-08.pdf
... of SARS-CoV HSR1 obtained from Vero E6-infected cells, a primer pair and probe specific for the detection of the sub- genomic nucleocapsid RNA were ...of SARS-CoV in Vero E6 and kidney cell ...
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Vaccines_to_prevent_severe_acute_respira.pdf
... MVA, SARS-CoV S protein has been expressed by several groups (Bisht et ...of SARS-CoV titers in the upper and lower respiratory tract after ...of SARS-CoV in the respiratory ...
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Induction of Specific Immune Responses by Severe Acute Respiratory Syndrome Coronavirus Spike DNA Vaccine with or without Interleukin-2 Immunization Using Different Vaccination Routes in Mice
... in SARS-CoV DNA vaccines, and therefore, its immune-modulating effects on the SARS-CoV S-protein DNA vaccine were investigated in the current ...
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