scavenger receptor-B I
CD36: a class B scavenger receptor involved in angiogenesis, atherosclerosis, inflammation, and lipid metabolism
... this receptor-ligand pair was shown to mediate interac- tions between platelets and monocytes, tumor cells, and ...ligand scavenger receptor (see ...collagens I and ...
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Scavenger receptor class B type I regulates cellular cholesterol metabolism and cell signaling associated with breast cancer development
... Previous studies have shown that Akt can inhibit apoptosis through a variety of mechanisms, including the phosphorylation of BAD, thus preventing cytochrome c release from mitochondria and the direct inhibition of the ...
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Hepatic expression of scavenger receptor class B type I (SR BI) is a positive regulator of macrophage reverse cholesterol transport in vivo
... While direct measures of flux of macrophage-derived cholesterol mass would clearly be desirable, it is impossible to detect the small pool of cholesterol mass derived specifically from macrophages. Furthermore, ...
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Different Requirements for Scavenger Receptor Class B Type I in Hepatitis C Virus Cell-Free versus Cell-to-Cell Transmission
... The ability of HCV to infect through direct cell-to-cell contact might contribute to the escape from neutralizing anti-HCV anti- bodies and the establishment and maintenance of chronic infec- tion (47). Previous reports ...
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Original Article Relationship between SR-BI genetic polymorphism and coronary heart disease and blood lipid level
... Scavenger receptor class B type I (SR-BI) is a high density lipoprotein receptor that can selec- tively mediate cholesteryl ester absorption [1, ...
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Initiation of Hepatitis C Virus Infection Is Dependent on Cholesterol and Cooperativity between CD81 and Scavenger Receptor B Type I
... (61), scavenger receptor B type I (SR-BI) (68), which is a cellular protein that binds high-density lipoprotein (HDL), the low-density lipoprotein receptor (LDL-R) (1, 52), the C-type ...
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The Tight Junction-Associated Protein Occludin Is Required for a Postbinding Step in Hepatitis C Virus Entry and Infection
... The precise mechanisms regulating hepatitis C virus (HCV) entry into hepatic cells remain unknown. However, several cell surface proteins have been identified as entry factors for this virus. Of these molecules, ...
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Key Role of the Scavenger Receptor MARCO in Mediating Adenovirus Infection and Subsequent Innate Responses of Macrophages
... Ad entry into and activation of innate signaling in MPI cells and AMs, unlike those in BMMs, are fast and efficient. Intracellular sensing of incoming virus particles is a major process in the triggering of antiviral ...
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Hypervariable Region 1 Deletion and Required Adaptive Envelope Mutations Confer Decreased Dependency on Scavenger Receptor Class B Type I and Low-Density Lipoprotein Receptor for Hepatitis C Virus
... In summary, HVR1 deletion and HVR1 deletion adaptive en- velope mutations did not affect the amount and trafficking of Core in the H77 viral life cycle from replication to release, whereas they had a significant impact ...
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A Library of Infectious Hepatitis C Viruses with Engineered Mutations in the E2 Gene Reveals Growth-Adaptive Mutations That Modulate Interactions with Scavenger Receptor Class B Type I
... input virus reflected the more rapid growth of the adaptive mu- tant strains over the course of the FFA compared to WT virus. Given this potential confounding issue, we performed a second confirmatory viral growth assay. ...
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Targeted disruption of the class B scavenger receptor CD36 protects against atherosclerotic lesion development in mice
... ator–activated receptor-γ (PPAR-γ) ligands (30, 31). Unlike SRA I/II, CD36 is more broadly expressed (32–35) and has been shown to play a strategic role in lipoprotein and lipid metabolism (36, ...
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Hepatic overexpression of bovine scavenger receptor type I in transgenic mice prevents diet induced hyperbetalipoproteinemia
... suppressed in TgSR+/- and TgSR+/+ mice. The rise in HDL was similar in control and TgSR+/- mice, but significantly elevated in the TgSR+/+ mice. Overall, on chow, the ratio of apo-B containing lipoprotein ...
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Scavenger Receptor Class B type 1 (SR-B1) and the modifiable risk factors of stroke
... type I and type II diabetes lead to risk factors that contribute to stroke, as type I diabetics are more prone to hypertension, coronary heart disease, peripheral ar- terial disease, and stroke attributable ...
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Human scavenger receptor class B, type II (SR-BII) and cellular cholesterol efflux
... finding, I proceeded to determine whether there is a stronger interaction between cytoplasmic SR-BII and the SH3 domain o f plc-yl when either its two adjacent SH2 signalling domains are present, or the plc-yl SH3 ...
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Scavenger Receptor Class B Type I and Hepatitis C Virus Infection of Primary Tupaia Hepatocytes
... Human scavenger receptor class B type I (SR-BI) represents an HCV receptor candidate mediating the cellular binding of E2 glycoprotein to HepG2 hepatoma ...
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Protein markers of dysfunctional HDL in scavenger receptor class B type I deficient mice
... SR-BI: scavenger receptor class B type I; TC: total cholesterol; TNF-α: tumor necrosis factor α; 2DE: 2D nondenaturing agarose-polyacrylamide gel ...
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Expression of the Scavenger Receptor Class B type I (SR BI) family in Drosophila melanogaster
... In the scope of our study, where we focused our attention on three developmental times in a variety of larval tissues, we could observe highly dynamic and, in some cases, restrictive patterns of expression. Some genes ...
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Regulation of scavenger receptor, class B, type I, a high density lipoprotein receptor, in liver and steroidogenic tissues of the rat
... The role of SR-BI in cholesterol transport and steroidogen- esis in humans remains to be established. Selective uptake of HDL-cholesteryl esters has been demonstrated in primary cul- ture of human hepatocytes (60) but ...
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Scavenger receptor class B type I is a multiligand HDL receptor that influences diverse physiologic systems
... Initially, scavenger receptor activity was identified as “AcLDL receptor activity” by Brown, Gold- stein, and colleagues (2), who were developing an in vitro model for the deposition of LDL ...
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Role of Scavenger Receptor Class B Type I in Hepatitis C Virus Entry: Kinetics and Molecular Determinants
... of receptor candidates have been proposed for HCV, including CD81, heparan sulfate proteoglycans (HSPGs), the TJ- associated proteins CLDN1 and OCLN, and SR-BI (5, 6, 22, 42, 43, ...
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