Scavenger receptor BI
Cholesterol binding, efflux, and a PDZ interacting domain of scavenger receptor–BI mediate HDL initiated signaling
... to scavenger receptor–BI (SR-BI) mediates cholesterol ...B scavenger receptors revealed that the C-terminal cytoplasmic PDZ-interacting domain and the C-terminal transmembrane domains ...
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Identification of a Residue in Hepatitis C Virus E2 Glycoprotein That Determines Scavenger Receptor BI and CD81 Receptor Dependency and Sensitivity to Neutralizing Antibodies
... CD81, scavenger receptor BI (SR-BI), and ...altered receptor dependency is accompanied by an increased sensitivity to neutralization by soluble CD81 and enhanced binding of recombinant ...
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Scavenger Receptor BI and BII Expression Levels Modulate Hepatitis C Virus Infectivity
... Hepatitis C virus (HCV) enters cells via a pH- and clathrin-dependent endocytic pathway. Scavenger receptor BI (SR-BI) and CD81 are important entry factors for HCV internalization into target ...
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Hepatoma Cell Density Promotes Claudin-1 and Scavenger Receptor BI Expression and Hepatitis C Virus Internalization
... To determine the effect(s) of increased SR-BI and CLDN1 cell contact expression on HCV infection, subconfluent and confluent Huh-7.5 cells were inoculated with JFH-1 or J6/JFH HCVcc for up to 6 h, and infectivity ...
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Differential effects of scavenger receptor BI deficiency on lipid metabolism in cells of the arterial wall and in the liver
... deficient mice are even slightly increased. We show that on a Western-type diet SRBI deficiency also did not alter the hepatic expression of HMG-CoA reductase, cholesterol 7 ␣ -hydroxylase, LDL receptor, CD36, ...
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In vivo regulation of scavenger receptor BI and the selective uptake of HDL cholesteryl esters in rat liver parenchymal and Kupffer cells
... Western Blot Analysis of Hepatic SR-BI Expression: Effect of F IG . 2. Western blot analysis of hepatic SR-BI expression after EE treatment or a high-cholesterol diet. Cell membranes from parenchymal and ...
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An apoA-I mimetic peptide facilitates off-loading cholesterol from HDL to liver cells through scavenger receptor BI
... carriers have low plasma HDL but are nevertheless protected from atherosclerosis, and SR-BI knockout mice have high plasma HDL but more advanced atherosclerotic lesions than their wildtype counter- parts. The ...
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Increased apolipoprotein M induced by lack of scavenger receptor BI is not activated via HDL-mediated cholesterol uptake in hepatocytes
... SR-BI − / − mice on a C57BL/6 background were kindly provided by Nanjing Medical University. The genotypes of the offspring of these mice were analyzed using the base-quenched probe method and gel electrophoresis, ...
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Hyperalphalipoproteinemic scavenger receptor BI knockout mice exhibit a disrupted epidermal lipid barrier
... To gain insight in the effects and underlying causes of differences observed between the barrier lipid pro fi le of WT control and SR-BI − / − mice, the expression of genes involved in skin lipid biosynthesis, up- ...
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Scavenger receptor BI plays a role in facilitating chylomicron metabolism
... of scavenger receptor class B type I (SR- BI) in mediating the selective uptake of high density lipoprotein (HDL) cholesterol esters is well ...additional receptor systems like the LDL ...
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Macrophage scavenger receptor CD36 is the major receptor for LDL modified by monocyte generated reactive nitrogen species
... Cells. Thioglycolate-elicited mouse peritoneal macrophages (MPM) from wild-type (C57BL/6) and CD36-null mice (42) were isolated and cultured as described (15). Resident MPM were similarly harvested from mice not ...
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Scavenger receptor class B type I is a multiligand HDL receptor that influences diverse physiologic systems
... “scavenger receptor” and the proposal (1, 3) that these receptors participate in the innate immune system by serving as pattern recognition receptors (5) that bind a wide variety of components of pathogens ...
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Expression of alpha 2 macroglobulin receptor/low density lipoprotein receptor related protein and scavenger receptor in human atherosclerotic lesions
... three receptor systems have been characterized that could be involved in the development of foam cells: alpha 2-macroglobulin receptor/LDL receptor-related protein (alpha 2 MR/LRP), scavenger ...
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New Insight into Mechanisms of Allograft Transplantation in the Rat by Differential Display: Macrophage Scavenger Receptor-A Brings to Light
... macrophage scavenger receptor-A (MSR-A) was clearly overexpressed in GIC from rejected compared to tolerant grafts and by quantitative RT/PCR; it exhibited up to 25-fold induction in mRNA expression on day ...
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Receptor-mediated phagocytosis of myelin by macrophages and microglia
... due solely to myelin phagocytosis, however recently it has been shown that native LDLs are present within the CNS, and that modified lipid-protein adducts, detected using antibodies derived against modified LDLs, are ...
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Dominant negative mutations of the scavenger receptor Native receptor inactivation by expression of truncated variants
... decrease in the uptake and degradation of Ac LDL but did not decrease the degradation of beta-migrating very low density lipoprotein, which is LDL receptor-mediated. These results demonstrate that expression of ...
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Vitamin D3 Induces Gene Expression of Ox-LDL Scavenger Receptors in Streptozotocin-Induced Diabetic Rat Aortas: New Insight into the Role of Vitamin D in Diabetic Atherosclerosis
... ox-LDL scavenger receptors in animal models of atherosclerosis is needed to confirm our ...that scavenger receptor expression is up-regulated in hyperglycemia and diabetes ...
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Is the class A macrophage scavenger receptor (SR A) multifunctional? — The mouse’s tale
... LDL receptor-deficient back- ground, which promotes susceptibility to diet-induced disease, the absence of SR-A only results in a marginal lesion reduction (16); for mice on the apoE3Leiden transgenic background, ...
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Hepatic uptake of a modified low molecular weight heparin in rats
... Because of their heterogeneous composition, it is difficult to study the pharmacokinetics of these drugs. We now report on a new method for labeling low molecular weight heparins with 131I by binding tyramine to the ...
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Selective targeting of microglia by quantum dots
... Our finding that QDs are selectively taken up by microglia is consistent with previous observations that QDs were localized to macrophages and microglia that infiltrate experimental gliomas [19]. However, in con- trast ...
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