Scavenger receptor class B type 1
Association of rs5888 SNP in the scavenger receptor class B type 1 gene and serum lipid levels
... The scavenger receptor class B type 1 (SCARB1) is the HDL receptor which binds HDL-C with high ...LDL-C receptor pathway, and plays an important role in reverse ...
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Scavenger Receptor Class B type 1 (SR-B1) and the modifiable risk factors of stroke
... Stroke is a devastating disease that affects populations around the world. Stroke is in the top three causes of mortality, and projections expect it to remain there in 2020 [1]. There are two primary categories of ...
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The rs5888 single nucleotide polymorphism in scavenger receptor class B type 1 (SCARB1) gene and the risk of premature coronary artery disease: a case-control study
... Logistic regression model was constructed to test the independent relationship between the rs5888 variants and the presence of CAD with the SNP coded as 0, 1, or 2 based on the number of risk (T) alleles. Analyses ...
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Glycine N-Methyltransferase Deficiency Affects Niemann-Pick Type C2 Protein Stability and Regulates Hepatic Cholesterol Homeostasis
... (ABCG1), scavenger receptor class B type 1 (SR-B1), 3-hydroxy-3-methyl-glutaryl- coenzyme A reductase (HMGCR), Niemann-Pick type C1 protein (NPC1), lysosome-associated ...
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Lupin protein isolate versus casein modifies cholesterol excretion and mRNA expression of intestinal sterol transporters in a pig model
... C1-like 1, scavenger receptor class B, type 1) were lower in pigs fed lupin protein isolate than in those who received casein (P < ...
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Protein markers of dysfunctional HDL in scavenger receptor class B type I deficient mice
... Plasma high-density lipoprotein (HDL) is a well-estab- lished cardiovascular protective factor with multiple functions, including mediating reverse cholesterol trans- port, and exerting anti-oxidative, anti-inflammatory, ...
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Scavenger Receptor Class B Type I and Hepatitis C Virus Infection of Primary Tupaia Hepatocytes
... FIG. 5. Specific and dose-dependent binding of anti-tupaia and human SR-BI antibodies to tupaia SR-BI. (A) Specific binding of rabbit anti-SR-BI (NB 400-104, left panel), mouse anti-tupaia SR-BI (middle panel), and mouse ...
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Hypervariable Region 1 Deletion and Required Adaptive Envelope Mutations Confer Decreased Dependency on Scavenger Receptor Class B Type I and Low-Density Lipoprotein Receptor for Hepatitis C Virus
... for 1 h at 37°C in four replicates with anti-ApoE MAb (1D7) in the indicated dilution series, along with four replicates with 50 g/ml of control antibody (mouse IgG1) and 6 replicates with medium ...
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Original Article Relationship between SR-BI genetic polymorphism and coronary heart disease and blood lipid level
... of scavenger receptor class B type I (SR-BI) exon 1 and intron 5 on blood lipid level and susceptibility to coronary heart disease (CHD) of Chinese Han popula- tion in ...exon ...
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Regulation of scavenger receptor, class B, type I, a high density lipoprotein receptor, in liver and steroidogenic tissues of the rat
... pared from human plasma by zonal centrifugation (4) and labeled with 3,3 9 -dioctadecylindocarbocyanine (DiI) from Molecular Probes, Inc. (Eugene, OR) as described (36). Labeled HDL preparations, which contained no ...
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Human scavenger receptor class B, type II (SR-BII) and cellular cholesterol efflux
... Since both HDL cholesterol and phospholipids are almost completely absent in plasm a from patients with Tangier disease, it was initially concluded that ABCAl functions to transport both o f these lipids across the plasm ...
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The Tight Junction-Associated Protein Occludin Is Required for a Postbinding Step in Hepatitis C Virus Entry and Infection
... protein 1, was required for HCV ...CD81, scavenger receptor class B type I, and claudin-1 were not affected upon occludin ...
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Role of Scavenger Receptor Class B Type I in Hepatitis C Virus Entry: Kinetics and Molecular Determinants
... lipoprotein receptor of 509 amino acids (aa) with cytoplasmic C- and N-terminal domains separated by a large extracellular domain (1, 13, ...endocytic receptor (45, 46, 51, ...putative ...
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Different Requirements for Scavenger Receptor Class B Type I in Hepatitis C Virus Cell-Free versus Cell-to-Cell Transmission
... Addition of C167 to the cocultures impaired the transmission of J6/JFH-1 to target cells in a dose-dependent manner but, intrigu- ingly, had no effect on clone 2 cell-to-cell spread (Fig. 4B). These findings ...
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Scavenger receptor class B type I regulates cellular cholesterol metabolism and cell signaling associated with breast cancer development
... rehydrated. Sections were treated with 20 μg/ml protein- ase K from Roche Applied Science (Indianapolis, IN, USA) for 15 min at room temperature and washed, and peroxidase activity was blocked by incubation in 3% ...
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Scavenger receptor class B type I is a multiligand HDL receptor that influences diverse physiologic systems
... multiligand scavenger receptor that binds anionic phospholipids and modi- fied proteins to be involved in pattern recognition for host defense and/or removal of senescent/apoptotic cells (1, ...one ...
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Hepatic expression of scavenger receptor class B type I (SR BI) is a positive regulator of macrophage reverse cholesterol transport in vivo
... Conversely, SR-BI–knockout mice have markedly increased ath- erosclerosis despite increased plasma levels of HDL-C (13–15), suggesting the possibility of impaired RCT. SR-BI–deficient or –attenuated mice have been shown ...
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Scavenger receptor class B member 1 protein: hepatic regulation and its effects on lipids, reverse cholesterol transport, and atherosclerosis
... Many of these SNPs are located downstream of the coding region, indicating that expression levels of SR-BI, likely in the liver, may be important for human HDL regulation. Interestingly, CD36 has not been associated at ...
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CD36: a class B scavenger receptor involved in angiogenesis, atherosclerosis, inflammation, and lipid metabolism
... which TSP-1/CD36 exerts an antiangiogenic response (37). A model of this pathway is shown in Figure 1. Studies in several cell types have shown that CD36 physically associates with nonreceptor protein ...
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Targeted disruption of the class B scavenger receptor CD36 protects against atherosclerotic lesion development in mice
... dothelial space and specific uptake of modified lipoproteins by scavenger receptors. Oxidative modi- fication of LDL is considered to be an essential step in the conversion of LDL into an atherogenic ligand for ...
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