scavenger receptor class BI
Regulations of the key mediators in inflammation and atherosclerosis by Aspirin in human macrophages
... the scavenger receptor class BI (SR-BI) and ATP-binding cassette transporter A1 (ABCA1) to promote cholesterol efflux in the foam cells at the plaques, and the role of NF- B in the ...
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Cholesterol binding, efflux, and a PDZ interacting domain of scavenger receptor–BI mediate HDL initiated signaling
... typical class II PDZ domain interaction (24). Furthermore, SR-BI deleted of the last C-terminal leucine (SR-BIΔ509) failed to interact with PDZK1 in vitro ...the receptor in close proxim- ity to ...
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Hepatic expression of scavenger receptor class B type I (SR BI) is a positive regulator of macrophage reverse cholesterol transport in vivo
... While direct measures of flux of macrophage-derived cholesterol mass would clearly be desirable, it is impossible to detect the small pool of cholesterol mass derived specifically from macrophages. Furthermore, ...
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Hyperalphalipoproteinemic scavenger receptor BI knockout mice exhibit a disrupted epidermal lipid barrier
... Scavenger receptor class B type I (SR-BI) mediates the selective uptake of cholesteryl esters (CE) from high- density lipoproteins (HDL). An impaired SR-BI function leads to ...
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Human scavenger receptor class B, type II (SR-BII) and cellular cholesterol efflux
... this receptor to be linked to a particular function in future cholesterol efflux and mobilisation ...surface receptor. Individual CHO-SR-BI/II cells were isolated for cloning by serial dilution, as ...
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Scavenger receptor BI plays a role in facilitating chylomicron metabolism
... introduce scavenger receptor class B type I (SR-BI) as a new player in postprandial lipid ...for scavenger class A receptors. In addition to CE, SR-BI selec- tively takes ...
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Protein markers of dysfunctional HDL in scavenger receptor class B type I deficient mice
... SR-BI: scavenger receptor class B type I; TC: total cholesterol; TNF-α: tumor necrosis factor α; 2DE: 2D nondenaturing agarose-polyacrylamide gel ...
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CD36: a class B scavenger receptor involved in angiogenesis, atherosclerosis, inflammation, and lipid metabolism
... CD36 colocalizes with caveolin-1 in specialized plasma membrane microdomains known as caveolae (11). These cholesterol- and sphingolipid-enriched structures may serve to concentrate signaling molecules and facilitate the ...
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Regulation of scavenger receptor, class B, type I, a high density lipoprotein receptor, in liver and steroidogenic tissues of the rat
... The numerous effects of estrogen on plasma lipoprotein levels, hepatic function, and pituitary function, led us to di- rectly assess the effects of a trophic hormone on SR-BI expres- sion in rat testes, where ...
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Original Article Relationship between SR-BI genetic polymorphism and coronary heart disease and blood lipid level
... of scavenger receptor class B type I (SR-BI) exon 1 and intron 5 on blood lipid level and susceptibility to coronary heart disease (CHD) of Chinese Han popula- tion in ...
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Scavenger receptor class B type I is a multiligand HDL receptor that influences diverse physiologic systems
... multiligand scavenger receptor that binds anionic phospholipids and modi- fied proteins to be involved in pattern recognition for host defense and/or removal of senescent/apoptotic cells (1, ...one ...
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The rs5888 single nucleotide polymorphism in scavenger receptor class B type 1 (SCARB1) gene and the risk of premature coronary artery disease: a case-control study
... Scavenger receptor class B type1 (SCARB1, also called SR-BI) is a multiligand cell surface receptor expresses both in macrophages and in the liver, indicating a major role for in the ...
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Differential effects of scavenger receptor BI deficiency on lipid metabolism in cells of the arterial wall and in the liver
... deficient mice are even slightly increased. We show that on a Western-type diet SRBI deficiency also did not alter the hepatic expression of HMG-CoA reductase, cholesterol 7 ␣ -hydroxylase, LDL receptor, CD36, ...
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Expression of the Scavenger Receptor Class B type I (SR BI) family in Drosophila melanogaster
... In the scope of our study, where we focused our attention on three developmental times in a variety of larval tissues, we could observe highly dynamic and, in some cases, restrictive patterns of expression. Some genes ...
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Anti class a scavenger receptor autoantibodies from systemic lupus erythematosus patients impair phagocytic clearance of apoptotic cells by macrophages in vitro
... that class A scavenger receptors expressed on the marginal zone macrophage play an important role in the link between apoptotic cells clearance and immune ...
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Identification of a Residue in Hepatitis C Virus E2 Glycoprotein That Determines Scavenger Receptor BI and CD81 Receptor Dependency and Sensitivity to Neutralizing Antibodies
... CD81 is a critical coreceptor for HCV particle entry (40, 45). The mutant virus demonstrated a 10-fold increase in the sen- sitivity to neutralization by hCD81 LEL, suggesting an in- creased affinity of the gps for CD81 ...
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Scavenger Receptor Class B type 1 (SR-B1) and the modifiable risk factors of stroke
... SR-B1 is a complex receptor affected by many comor- bidities associated with stroke. The current literature shows that SR-B1 has both positive and negative effects. Some of the risk factors, such as smoking and ...
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LRP: a multifunctional scavenger and signaling receptor
... While the locations of the ligand recognition sites for all ligands within LRP are not yet known, two general approaches have been successfully employed to identi- fy the regions responsible for binding a number of lig- ...
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Association between APOE, SCARB1, PPARα polymorphisms and serum lipids in a population of Lithuanian adults
... Morabia A et al. found higher LDL-C in women with the T allele [9]. We did not observe any association between the SCARB1 genotype and dyslipidemia in women. Several studies have shown that a rare T variant was ...
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Hepatoma Cell Density Promotes Claudin-1 and Scavenger Receptor BI Expression and Hepatitis C Virus Internalization
... of receptor expression by pseudolinear profiling of individual cells confirmed that CLDN1 and SR-BI cell contact expression was significantly enhanced in confluent compared to subconfluent cells ...
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