SDF-1α/CXCR4
Combination of Atorvastatin–Endurance Training Has Positive Effect on Apoptosis and Protein Expression of SDF-1α/CXCR4 Axis after Myocardial Infarction in Rat's Heart Tissue
... cognate CXCR4 receptor on the stem and progenitor cells and plays a crucial role in gathering and recruitment of stem cells into the infarcted ...that SDF-1α induced mobilization of the bone ...
5
Hypoxia-inducible factor 1α (HIF-1α) and reactive oxygen species (ROS) mediates radiation-induced invasiveness through the SDF-1α/CXCR4 pathway in non-small cell lung carcinoma cells
... factor 1α (HIF-1α), which is induced by hypoxia, confers protection against cell death and plays an adaptive ...factor 1α (SDF-1α), also known as C-X-C motif chemokine 12 (CXCL12), can ...
15
Modulation of stromal cell-derived factor 1 alpha (SDF-1α) and its receptor CXCR4 in Porphyromonas gingivalis-induced periodontal inflammation
... of SDF-1α at inflamma- tion sites serves as a potent chemoattractant to recruit circulating or residing CXCR4-expressing cells to lesions, with high differentiation and proliferation potential to act ...
8
Original Article Granulocyte colony-stimulating factor suppresses SDF-1α/CXCR4 and mobilizes regulatory T cells in acute myelogenous leukemia
... intracellular CXCR4 levels were found to be elevated in a subset of AML cases ...of SDF-1α/CXCR4 signaling repre- sents a novel strategy for targeting leukemia/ bone marrow microenvironment ...
11
Paracrine SDF-1α signaling mediates the effects of PSCs on GEM chemoresistance through an IL-6 autocrine loop in pancreatic cancer cells
... paracrine SDF- 1α ...the SDF-1α/CXCR4 signaling pathways may be a promising therapeutic strategy for overcoming chemoresistance in pancreatic ...
13
Original Article Icariin administration is associated with enhanced homing of bone marrow-derived progenitor cells, increased levels of CXCR-4/SDF-1α homing factors, and attenuated brain injury in a rat stroke model
... and CXCR4 are significantly elevated. These results raise the possibility that the SDF-1α/ CXCR4 axis might play a crucial role in regulat- ing BMSC migration in the ischemic brain. Icariin ...
10
Stromal cell derived factor 1alpha protects stem cell derived insulin producing cells from glucotoxicity under high glucose conditions in vitro and ameliorates drug induced diabetes in rats
... roles. SDF- 1/CXCR4 axis modulates cell migration and cell survival during develop- ment and tissue remodeling ...Moreover, SDF-1α /CXCR4 is an obligatory component in the maintenance ...
10
PubMedCentral-PMC5711687.pdf
... in SDF-1α protein levels between the non-infarcted control group and the four experimental infarcted ...increase SDF-1α protein levels, compared with the CON group at 60 minutes after ...
11
Original Article SDF-1α promotes repair of myocardial ischemic necrosis zones in rats
... CXC, SDF-1α causes chemotaxis. Abbott et al. [28] found that SDF-1α mRNA expression increased 48 h and 72 h after myocardial infarction, and it recovered 7 d ...later. SDF-1α ...
12
SDF-1α Reduces Human Natural Killer Cell Cytotoxicity against Chronic Myelogenous Leukemia K562 Cells
... the SDF- 1α/CXCR4 ...study, SDF-1α has been reported to modulate the immune- suppression in B cell lymphoma microenvironment through the accumulation of regulatory T cells that was ...
8
Cancer-associated fibroblasts promote the progression of endometrial cancer via the SDF-1/CXCR4 axis
... of SDF-1α and (3) CAFs promoted EC cells progression via the SDF-1/ CXCR4 axis in a paracrine-/autocrine-dependent man- ...(4) SDF-1α expression was upregulated and was as- ...
15
Mobilization of hematopoietic stem cells from the bone marrow niche to the blood compartment
... of HSPCs from the bone marrow niche. Intriguingly, while optimal mobilization occurs in the morning in mice (Zeitgeber time 5), HSC mobilization circadian control is inverted in humans, with peak mobilization occurring ...
8
Hypoxia-induced the upregulation of stromal cell-derived factor 1 in fibroblast-like synoviocytes contributes to migration of monocytes into synovium tissue in rheumatoid arthritis
... Hypoxia is a constant feature of synovial microenviron- ment in RA. Synovial hypoxia is thus considered a poten- tial pathogenic factor in RA. It has been demonstrated that oxygen tension in the synovial fluid of RA ...
11
Purinergic P2X4 receptors and mitochondrial ATP production regulate T cell migration
... minutes), or with the mitochondrial membrane potential and ROS- sensitive dye MitoTracker Red CM-H2Xros (100 nM, 10 minutes) in cell culture medium buffered with 20 mM HEPES. To image ATP release at the cell surface, ...
13
Original Article Estrogen receptor ESR1 promotes BMSCs cell proliferation and migration via regulation of SDF-1/CXCR4 signaling
... Abstract: Stromal cell-derived factor-1 (SDF-1) and its membrane receptor C-X-C chemokine receptor type 4 (CXCR4) are involved in the proliferation and migration of multiple stem cell types which are ...
8
High expression of CXCR4, CXCR7 and SDF 1 predicts poor survival in renal cell carcinoma
... of CXCR4 in 48 ...of CXCR4 was observed in all specimens of RCC, with fewer cases show- ing additional membranous or nucleolar ...clear CXCR4 expression has been described in breast cancer [15] and ...
8
Field cancerisation in colorectal cancer
... 2005 Keratinocyte growth factor receptor expression in normal colorectal epithelial cells and differentiated type of colorectal cancer.. 2008 Expression of SDF-1 alpha and nuclear CXCR4 [r] ...
292
Original Article Expression of SNCG, MAP2, SDF-1 and CXCR4 in gastric adenocarcinoma and their clinical significance
... MAP2, SDF-1, CXCR4 and GAPDH amplification 50 ng cDNA templates; made to a total volume of 20 μl with sterile H 2 ...of SDF-1 mRNA, CXCR4 mRNA and GAPDH (2) mRNA have a molecular weight of 103 ...
10
CXC chemokine receptor 4 expressed in T cells plays an important role in the development of collagen induced arthritis
... from Cxcr4 +/+ /Lck-Cre or Cxcr4 flox/flox /Lck-Cre mice were harvested and cultured in the presence or absence of 50, and 100, 200 μ g/ml of denatured IIC at 37°C for 72 hours, and T-cell proliferation was ...
14
Electroacupuncture preconditioning reduces cerebral ischemic injury via BDNF and SDF 1α in mice
... of SDF-1α in the ...and SDF-1α, colocalized within the cerebral vascular endothelium, was observed throughout the ischemic cortex following ...
9