Second-line injectable drugs
Diagnostic Performance of the New Version (v2 0) of GenoType MTBDRsl Assay for Detection of Resistance to Fluoroquinolones and Second Line Injectable Drugs: a Multicenter Study
... and second-line injectable drugs (SLID) is steadily increasing, especially in eastern Euro- pean countries, posing a serious threat to effective tuberculosis (TB) infection control and ...
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Performance of the New Version (v2 0) of the GenoType MTBDRsl Test for Detection of Resistance to Second Line Drugs in Multidrug Resistant Mycobacterium tuberculosis Complex Strains
... The overall performance of MTBDRsl v2.0 determined in our study was similar to that reported in the only other published study evaluating this test. Tagliani et al. found sensitivity and spec- ificity values for direct ...
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A Study on Molecular Detection of Mutations Associated with Second Line Anti-tuberculosis Drug Resistance
... first line anti-TB drugs, have emerged worldwide and seriously threaten TB control and prevention ...first- line antibiotics must be replaced with second-line drugs that are more ...
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The GenoType® MTBDRsltest for resistance to second-line anti-tuberculosis drugs (Protocol)
... These drugs are two of the most effective and widely-used anti-TB drugs that form part of the standardized first-line regimen for drug-susceptible ...fluoroquinolone drugs and ...
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Frequency and patterns of second-line resistance conferring mutations among MDR-TB isolates resistant to a second-line drug from eSwatini, Somalia and Uganda (2014–2016)
... anti-TB drugs, rifampicin and ...three second-line injectable drugs: amikacin (AMK), kanamycin (KAN), and capreomycin (CAP) ” ...anti-TB drugs, and the World Health Organization ...
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The diagnostic accuracy of the GenoType®MTBDRslassay for the detection of resistance to second-line anti-tuberculosis drugs (Review)
... These drugs are two of the most effective and widely- used anti-TB drugs that form part of the standardized first-line reg- imen for drug-susceptible ...with drugs belonging to the ...
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Nephrotoxicity and ototoxic symptoms of injectable second-line anti-tubercular drugs among patients treated for MDR-TB in Ethiopia: a retrospective cohort study
... with injectable treatment, but final treatment outcomes were also recorded after standard duration of ...anti-TB drugs at baseline, other co-morbidities and concomitant medications, description of TB type, ...
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Prevalence of Pre - Extensively Drug Resistance Tuberculosis (Pre XDR-TB) & Extensively Drug Resistance Tuberculosis (XDR-TB) among Pulmonary Multidrug Resistance Tuberculosis at a Tertiary Care Hospital, Jamnagar
... anti-TB drugs (Rifampicin and/or Isoniazid) with additional resistance to second-line ...three injectable second-line drugs ...TB drugs, patient are left with ...
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Totally Drug-Resistant Tuberculosis (TDR-TB): An Overview
... first line- antitubercular drugs in addition to resistant to any fluoroquinolones ...three injectable second-line anti-TB drugs ...anti-TB drugs (FLD) and ...
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Extensively drug-resistant tuberculosis: epidemiology and management
... and second-line drugs beyond those included in the ...all second-line injectable agents (n = 68, treat- ment success 34%), and made still worse by the further addition of ...
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Increased Tuberculosis Patient Mortality Associated with Mycobacterium tuberculosis Mutations Conferring Resistance to Second Line Antituberculous Drugs
... of second-line injectables (KAN MICs of ⬎ 20 to 80 g/ml) (1, 13), corresponding to resistance levels that may exceed the clinical efficacy of KAN and other injectable drugs ...that ...
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Detection of Resistance to Second Line Antituberculosis Drugs by Use of the Genotype MTBDRsl Assay: a Multicenter Evaluation and Feasibility Study
... The inability of the assay to detect resistance to kanamycin in our study significantly affected its performance characteristics in regard to the detection of resistance to the group of injectable drugs and ...
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Rapid Detection of Mycobacterium tuberculosis Resistance to Second Line Drugs by Use of the Manual Mycobacterium Growth Indicator Tube System
... three injectable second-line drugs (kanamycin [KAN], amika- cin [AK], and/or capreomycin [CM]) is a real threat for TB control programs ...first-line drugs but also to ...
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Deficient supplies of drugs for life threatening diseases in an African community
... We noted that the supply of anti-malarial drugs was some- what better than that of drugs used to treat pneumonia. There could be various explanations for this, including the fact that malaria, along with ...
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Plasma concentrations of second-line antituberculosis drugs in relation to minimum inhibitory concentrations in multidrug-resistant tuberculosis patients in China: a study protocol of a prospective observational cohort study
... In this prospective observational cohort study, we present a comprehensive, translational approach to TDM studies in MDR-TB, likely to be of benefit in future trials in the area. Multiple blood sampling and individual ...
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From micro- to nanostructured implantable device for local anesthetic delivery
... surgery and release LAs in a tailored manner. Irrespective of the origin of pain, management is necessary in clinical prac- tice leading to essential benefits including shorter hospital stay and improved patient ...
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Head-to-head comparison of 1-year aripiprazole long-acting injectable (LAI) versus paliperidone LAI in comorbid psychosis and substance use disorder: impact on clinical status, substance craving, and quality of life
... Our results showed both drugs to be safe, with tolerable side effects. Each drug produced side effects that would have been expected by its oral formulation, that is, akathisia with aripiprazole and ...
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The Application of the Therapeutic Drug Monitoring (TDM) of First and Second-Line Drugs for Multidrug-Resistant Tuberculosis Patients (MDRTB)
... Due to an unfamiliarity of TDM related to MDRTB in Thailand, there were still some limitations including numbers of experts in TDM skills, knowledge and skills, budget available, and the responsibility of both health ...
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Performance evaluation of the compounding robot, APOTECAchemo, for injectable anticancer drugs in a Japanese hospital
... ophilized drugs during the study period are shown in ...lyophilized drugs in advance (pre-reconstitution) in January 2015 and then this practice boosted in June 2015 Table 1 Concentrations of ...
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Comparison of heart failure risk and medical costs between patients with type 2 diabetes mellitus treated with dapagliflozin and dipeptidyl peptidase-4 inhibitors: a nationwide population-based cohort study
... © The Author(s) 2020. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you ...
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