Secreted factors
An RNAi screen for secreted factors and cell-surface players in coordinating neuron and glia development in Drosophila
... WG-derived factors that modulate neuronal development in the fly ...for secreted factors and cell-surface receptors, we identified 13 knockdown lines that caused defects in the development of R ...
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The WIF domain of the human and Drosophila Wif 1 secreted factors confers specificity for Wnt or Hedgehog
... The Hedgehog (Hh) and Wnt signaling pathways are crucial for development as well as for adult stem cell maintenance in all organisms from Drosophila to humans. Aberrant activation of these pathways has been implicated in ...
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Pleiotropic effects of cancer cells’ secreted factors on human stromal (mesenchymal) stem cells
... to secreted factors present in conditioned media (CM) from a panel of human tumor cell lines covering a spectrum of human cancers (breast, prostate, lung, colon, and head and ...
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Inflammatory priming enhances mesenchymal stromal cell secretome potential as a clinical product for regenerative medicine approaches through secreted factors and EV-miRNAs: the example of joint disease
... with secreted factors, MSC-derived EVs have been shown to replicate the therapeutic effects observed with the entire secretome [78] by transfer of DNA, pro- teins/peptides, lipids, organelles, mRNAs, and ...
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Therapeutic Potential of Lung Spheroid Cell-Secreted Factors in Rodent Models of Pulmonary Fibrosis.
... In summary, we report here novel acellular therapeutic agents, namely LSC-CM and LSC-EXO, that are shown to be safe and effective in the treatment of bleomycin- and silica- induced pulmonary fibrosis in rodents. The ...
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Cataloguing of Potential HIV Susceptibility Factors during the Menstrual Cycle of Pig-Tailed Macaques by Using a Systems Biology Approach
... other factors that increase risk of HIV-1 acquisition ...of secreted factors and spe- cific regulatory protein assays to extensively explore proteins that are at play in the genital tracts of ...
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Immunoregulatory potential of mesenchymal stem cells following activation by macrophage-derived soluble factors
... with secreted factors from human monocyte-derived macrophages polarized toward a pro-inflammatory or an anti-inflammatory phenotype using standard two-dimensional (2D) culture ...priming factors for ...
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Soluble factors secreted by differentiating embryonic stem cells stimulate exogenous cell proliferation and migration
... growth factors that were differentially expressed by differentiating ESCs and the impact of this complex mixture of secreted factors on different somatic cell types found in most ...
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Targeting microenvironment in cancer therapeutics
... (EMT), secreted factors, cancer-associated fibroblasts (CAFs), the host immune response, and tumor-associated microphages (TAM) are critical for cancer progression and ...
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Adipose stem cells can secrete angiogenic factors that inhibit hyaline cartilage regeneration
... In addition to affecting hypertrophic differentiation, the length of exposure to ASC-secreted factors and the time points measured appear to be important variables in reg- ulating chondrocyte phenotype. ...
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Primary tumor- and metastasis-derived colon cancer cells differently modulate connexin expression and function in human capillary endothelial cells
... The factors secreted by less motile SW620 cells do not affect Cx43 expression but up-regulate the expression of the connexin Cx32 through an activation of the chemokine receptor ...SW620 secreted ...
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Molecular mechanisms and treatment strategies for Dupuytren’s disease
... The current hypothesis that we are working on is that DD cells modify their extracellular environment by secreting (or depleting) molecules that promote (or inhibit) myofibroblast differentiation in their collagenous ...
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Mechanically stimulated bone cells secrete paracrine factors that regulate osteoprogenitor recruitment, proliferation, and differentiation
... and secreted factors within the conditioned media were collected and used to evaluate mesenchymal stem cell (MSC) and osteoblast recruitment, proliferation and ...Paracrine factors secreted by ...
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Contrasted evolutionary constraints on secreted and non-secreted proteomes of selected Actinobacteria
... pairwise Ka/Ks ratio analysis of all the orthologous genes; both core and non-core (please refer to ‘Secretory protein vs. non-secretory protein in Pairwise comparison’ section). The normal distribution (Gaussian) curve ...
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Genomics and proteomics approaches to the study of cancer-stroma interactions
... Fibroblasts, as other cells in tumor microenvironments, need to maintain close communication with cancer cells, promoting proliferation, recruitment of inflamma- tory cells and acquisition of invasive characteristics. ...
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Trps1 activates a network of secreted Wnt inhibitors and transcription factors crucial to vibrissa follicle morphogenesis
... To identify the transcriptional targets of Trps1 in the developing vibrissa follicle, we performed microarray hybridization analysis, comparing expression patterns in the whisker pads of[r] ...
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Androgen receptor in Sertoli cells regulates DNA double-strand break repair and chromosomal synapsis of spermatocytes partially through intercellular EGF-EGFR signaling
... Other factors or signaling events potentially act as downstream effectors of AR signaling and must be activated or ...disordered factors or signaling events require modification, our rescue experiments may ...
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Activated hepatic stellate cells promote angiogenesis via interleukin 8 in hepatocellular carcinoma
... In this paper, we demonstrated that a-HSCs played an important role in angiogenesis associated with HCC. A-HSCs secreted IL-8, which in turn stimulated hepatoma cells (Hep3B and Huh-7) to express angiogenic ...
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Controlling Thermogenesis: Understanding the Role of PRDM16 in the Development and Function of Brown Fat
... First, many of the thermogenic inducers, like Irisin, Bmp8b, Orexin, NPs, Sirt1, etc. were identified very recently as having effects on brown/beige fat biology. While the early findings are very promising, many more ...
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Staphylococcal Virulence Factors on the Skin of Atopic Dermatitis Patients
... teases, and lipase (22, 23). Superantigens include toxic shock syndrome toxin-1 (TSST- 1), staphylococcal enterotoxins (SEs), and staphylococcal enterotoxin-like toxins (SEls) (24). Superantigens are commonly ...
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