Selective estrogen-receptor modulators
Selective estrogen receptor modulators: tissue specificity and clinical utility
... Abstract: Selective estrogen receptor modulators (SERMs) are a diverse group of nonsteroidal compounds that function as agonists or antagonists for estrogen receptors (ERs) in a target ...
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The effect and safety of postmenopausal hormone therapy and selective estrogen receptor modulators on kidney outcomes in women: a protocol for systematic review and meta-analysis
... and selective estrogen receptor modulators on kidney outcomes in ...including selective estrogen receptor modulators, on kidney function and albuminuria, as well as ...
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Estrogen receptor transcription and transactivation Estrogen receptor alpha and estrogen receptor beta: regulation by selective estrogen receptor modulators and importance in breast cancer
... the estrogen receptor (ER), now referred to as selective estrogen receptor modulators (SERMs), can demonstrate remarkable differences in activity in the various estrogen ...
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Breast related effects of selective estrogen receptor modulators and tissue selective estrogen complexes
... combined estrogen-progestin therapy, and a small increased risk of breast cancer and breast pain or ...cancer. Selective estrogen receptor modulators (SERMs) provide bone protection, ...
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Selective estrogen receptor modulators inhibit growth and progression of premalignant lesions in a mouse model of ductal carcinoma in situ
... The model described here was derived by transplanting focal mammary lesions from mouse mammary tumor virus (MMTV) polyomavirus middle T (PyV-mT) transgenic mice to syngeneic wild-type host mammary fat pads. The ...
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The differential effects of bisphosphonates, SERMS (selective estrogen receptor modulators), and parathyroid hormone on bone remodeling in osteoporosis
... as receptor activator of nuclear factor kappa B ligand (RANKL) and macrophage-colony stimulating factor (M-CSF), released in the bone microenvironment by osteogenic cells and by marrow stroma (Hughes et al 1996; ...
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Genome-wide transcriptional regulation of estrogen receptor targets in fallopian tube cells and the role of selective estrogen receptor modulators
... tube) estrogen receptor expression was confirmed and interaction with its ligand, estradiol, triggered mRNA and protein induction of progesterone receptor ...as estrogen receptor ...
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Selective estrogen receptor modulator (SERM) for the treatment of osteoporosis in postmenopausal women: focus on lasofoxifene
... Abstract: Selective estrogen receptor modulators (SERMs) represent a class with a growing number of compounds that act as either estrogen receptor agonists or antagonists in a ...
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Current treatment options for postmenopausal vaginal atrophy
... Abstract: Vulvovaginal atrophy (VVA) is a silent epidemic that affects up to 50%–60% of postmenopausal women who are suffering in silence from this condition. Hormonal changes, especially hypoestrogenism inherent in ...
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Identification and characterization of noncalcemic, tissue selective, nonsecosteroidal vitamin D receptor modulators
... tissue-selective estrogen receptor modulators (SERMs) that are agonist in bone and antagonist or transcriptionally inactive in breast and uterine cells (21, 22), we synthesized ...
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The Transactivating Function 2 (AF 2) of Estrogen Receptor (ER) α Is Indispensable for ERα Mediated Physiological Responses and AF 1 Activity
... Various estrogen receptor antagonists and selective estrogen receptor modulators (SERMs) have been de- veloped in pharmaceutical research by analyzing deriva- tives of certain ...
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Beliefs About Medication and Uptake of Preventive Therapy in Women at Increased Risk of Breast Cancer: Results From a Multicenter Prospective Study
... In a meta-analysis of 9 randomized trials, women at increased risk of breast cancer had at least a 30% lower risk of the disease if they used selective estrogen receptor modulators.2 The[r] ...
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Lead Optimization of Benzoxepin Type Selective Estrogen Receptor (ER) Modulators and Downregulators with Subtype Specific ER alpha and ER beta Activity
... extremely selective effect on ...pure estrogen antagonist 5, a known SERD, downregulates the expression of ERα and was used as a positive ...the estrogen-signaling process and thus inducing ...
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Effects of Estrogen Receptor Modulators on Morphine Induced Sensitization in Mice Memory
... 46. Nickelsen T, Lufkin EG, Riggs BL, Cox DA, Crook TH. Raloxifene hydrochloride, a selective estrogen receptor modulator: safety assessment of effects on cognitive function and mood in ...
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Benzoxepin Type Selective Estrogen Receptor (ER) Modulators and Downregulators with Subtype Specific ERalpha and ERbeta Activity
... a selective palladium-catalyzed and copper- assisted direct C-H (hetero)-arylation of thiazolo[5,4-f]quinazolin-9(8H)-one has been developed with aryl halides as coupling partners under microwave ...
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Discovery of Selective Estrogen Receptor Covalent Antagonists for the Treatment of ERαWT and ERαMUT Breast Cancer.
... the receptor, either through covalent or non-covalent interactions, or a combination of both, in a primary or allosteric binding ...the receptor is in the antagonist conformation ...
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Estrogen receptor transcription and transactivation Estrogen receptor knockout mice: what their phenotypes reveal about mechanisms of estrogen action
... mammals. Estrogen is primarily known for its role in the development and functioning of the female reproductive ...for estrogen in male fertility, bone, the circulatory system and immune system have been ...
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Original Article The expression of transcription factor BORIS and its association with the estrogen receptor beta (ER-β) in cervical carcinogenesis
... Because of these discrepancies, various re- search groups evaluated and compared 7 [39], 8 [40] and 11 [41] different ER-β antibodies to determine those best at detecting ER-β through IHC. The 14C8 antibody proved to be ...
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The effect of environmental stress and selective glucocorticoid receptor modulators on chicken and human leukaemia cells
... glucocorticoid receptor can be considered as one mechanism involved in regulation of GR mediated target gene ...Glucocorticoid receptor has been described to undergo methylation (Guo et ...
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The Effects of Estrogen Receptors' Antagonist on Brain Edema, Intracranial Pressure and Neurological Outcomes after Traumatic Brain Injury in Rat
... that estrogen reduces BBB damage in the ischemia model through constraining the expression of the matrix metaloproteinase 2 and 9 genes and the vascular endothelial growth factor ...
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