self-renewal
HPV16 E2 protein modifies self renewal and differentiation rate in progenitor cells of human immortalized keratinocytes
... The presence of mRNA from transcription factors SOX2 , NANOG and OCT4 (Fig. 1, panels d and e), whose expression has been reported for progenitor cells in normal keratinocytes [56, 61], only in the α6- integrin bri /CD71 ...
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Loss of quiescence and self-renewal capacity of hematopoietic stem cell in an in vitro leukemic niche
... Also, it has been reported that fast-dividing cells have limited self-renewal and reconstitution capabilities [44, 45]. We have also recently shown, that HSC in a leukemic microenvironment set with REH ...
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p53 enables metabolic fitness and self renewal of nephron progenitor cells
... of self-renewal potential (Cicalese et ...restricts self-renewal capacity and the size of the stem and/or progenitor pool, data from mouse embryonic stem cells suggest that p53 serves as a ...
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Three steps to the immortality of cancer cells: senescence, polyploidy and self-renewal
... important for tumour control as if the immune response is suppressed, cancer develops [9,10]. Recent work shows that tetraploid cells specifically (in a colon cancer cell-line at least) upregulate the immunostimulatory ...
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Integrin Rac signalling for mammary epithelial stem cell self renewal
... Background: Stem cells are precursors for all mammary epithelia, including ductal and alveolar epithelia, and myoepithelial cells. In vivo mammary epithelia reside in a tissue context and interact with their milieu via ...
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Optogenetic stimulation inhibits the self-renewal of mouse embryonic stem cells
... Mouse embryonic stem cells (mESCs) derived from the inner cell mass of blastocysts are considered multi- pluripotent with the characteristic of rapid self-renewal [1]. MESCs have been widely used to study ...
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The NOTCH1-HEY1 pathway regulates self-renewal and epithelial-mesenchymal transition of salivary adenoid cystic carcinoma cells
... Our previous study demonstrated a close relationship between the NOTCH signaling pathway and salivary adenoid cystic carcinoma (SACC). Its receptor gene, NOTCH1, and its downstream gene, HES1, contribute to the ...
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ERK inhibition promotes neuroectodermal precursor commitment by blocking self-renewal and primitive streak formation of the epiblast
... and had little effect on OCT4 expression (Fig. 3d, e, Add- itional file 4: Figure S3A – D). However, PD0325901 treat- ment inhibited both NANOG and OCT4 efficiently, representing a more powerful effect for EpiSC ...
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Self-Renewal and Differentiation of Adipose-Derived Stem Cells (ADSCs) Stimulated by Multi-Axial Tensile Strain in a Pneumatic Microdevice
... Because the self-renewal capacity of the ADSCs could be induced by the mechanical stretching, investigation of the cell proliferation was conducted. The ADSCs (isolated from the tissue samples of patient #1 ...
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RhoGDIα suppresses self-renewal and tumorigenesis of glioma stem cells
... in GSCs. As expected, Ectopic expression of RhoGDIα inhibited RhoA activity. Consistently, the phosphorylated level of myosin phosphatase (MYPT1) which is associated with the activity of ROCK1 also decreased (Figure 5A). ...
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S6K1 regulates hematopoietic stem cell self renewal and leukemia maintenance
... Our studies reveal that the self-renewal of HSCs and leukemic potential of these cells are similarly dependent on S6K1. Further- more, loss of S6K1 in HSCs increases the susceptibility of mice to repeated ...
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Spermatogonial Stem Cells: A Review of Essential Factor for Self-Renewal and Differentiation
... Fig. 1: A schematic representation of signaling model towards self-renewal and differentiation of SSC. BCL6b: B cell CLL/lymphoma 6; bFGF: Basic fibroblast growth factor; EGF: Epidermal growth factor; ETV5: ...
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Ash1l controls quiescence and self renewal potential in hematopoietic stem cells
... normal HSCs, cells could efficiently engraft the BM and establish durable hematopoiesis in Ash1l-deficient mice, suggesting poor competition of residual HSCs for niche space. Despite profound defects in transplantation ...
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SIRT1 suppresses self renewal of adult hippocampal neural stem cells
... NSC self-renewal, Notch signaling represses the expression of pro-neuronal genes through Notch targets, such as Hes1 and Hes5 (Louvi and Artavanis-Tsakonas, ...aNSC self-renewal (Meletis et ...
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Akt mediates self renewal division of mouse spermatogonial stem cells
... study self-renewal, as it is possible to collect high numbers of stem cells for molecular characterization and genetic manipulation (Kanatsu-Shinohara et ...the self- renewal of ES cells, ...
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Neural stem cells: balancing self renewal with differentiation
... in self- renewal is to identify mutations that alter spindle orientation without disrupting cortical polarity; this has only been shown for one, perhaps two, genes so ...
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Targeting self-renewal pathways in myeloid malignancies
... regulate self-renewal capacity [58], its role in LSCs is still not fully defined, however various reports suggest it can suppress differentiation and augment the immature cell phenotype in myeloid ...
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Mammary stem cells, self renewal pathways, and carcinogenesis
... of self-renewal and multi-lineage differentiation ...the self-renewal and differentiation of normal mammary stem and progenitor cells (see ...
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Stem cells, senescence, neosis and self-renewal in cancer
... newly synthesized viable genome to the daughter Raju cells, while retaining the non-viable defective polyploid genome, which is eliminated after the production of daughter Raju cells. The latter also display some degree ...
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Hmga2 regulates self renewal of retinal progenitors
... RPC self-renewal depends upon modulation of Hmga2 transcript levels, not their presence alone, points to the significance of stoichiometry in Hmga2 expression levels for cells acquiring the ...
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