Sequestration and cytoadherence
Cytoadherence and Severe Malaria
... reduce cytoadherence as might be expected from previous work, and there is some evidence that fever temperatures might act in the opposite way to reduce endothelial cell binding (Craig, unpublished ...to ...
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Pathogenesis of cerebral malaria - inflammation and cytoadherence
... disease. Cytoadherence of iRBC of the PfEMP1-DC8 and DC13 variants to endothelial receptors (like EPCR and ICAM-1) leads to sequestration and a reduction in microvascular ...
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Cytoadherence and virulence the case of Plasmodium knowlesi malaria
... for cytoadherence and, therefore, sequestration of late tro- phozoite and schizont infected erythrocytes from the peripheral blood circulation in ...
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Investigations of anti-adhesion and endothelial environment for plasmodium falciparum cytoadherence
... falciparum pRBC rosettes. Here, we investigate that effect by using sulphated polysaccharides and modified heparin for their effect to interrupt pRBC sequestration. We found that not all sulphated compounds or ...
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Cerebral malaria is associated with differential cytoadherence to brain endothelial cells
... have cytoadherence properties that enable them to bind to brain endothelium and thus enhancing their sequestration in that site has not been ...IE sequestration than CM cases (Milner et al, ...
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A semi-synthetic glycosaminoglycan analogue inhibits and reverses Plasmodium falciparum cytoadherence.
... Polysaccharides such as dextran sulfate and fucoidan can inhibit adhesion of P . falciparum to host receptors such as CSA and CD36 [12–14] and regioselectively modified polysaccha- rides, including modified carrageenans ...
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Specific receptor usage in Plasmodium falciparum cytoadherence is associated with disease outcome.
... falciparum variants from the field as shown in this study and in laboratory lines [63] that exhibit differential adhesion abilities to all three ICAM-1 proteins. When we tested patient isolates for their ability to bind ...
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Thrombin Cleavage of Plasmodium falciparum Erythrocyte Membrane Protein 1 Inhibits Cytoadherence
... falciparum sequestration, which would have allowed for the examination of PfEMP1 cleavage in the complex milieu of an acute infection, the presence of thrombin in cerebral microvessels and the inverse correlation ...
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ICAM 1 is a key receptor mediating cytoadherence and pathology in the Plasmodium chabaudi malaria model
... parasite sequestration in the liver occurs concomitantly with a reduced load in the spleen, thus peripheral blood parasitaemia increases and parasite clearance is ...parasite sequestration in the liver is ...
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Amplification of P. falciparum Cytoadherence through Induction of a Pro-Adhesive State in Host Endothelium.
... efficient sequestration of IE seen early in an infection in the absence of profound systemic host activation and the pathophys- iology of severe malaria based on the targeted recruitment of parasite variants to ...
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Continued cytoadherence of Plasmodium falciparum infected red blood cells after antimalarial treatment.
... to sequestration of trophozoite-stage infected red blood cells in the ...of cytoadherence is mediated by binding of the parasite protein PfEMP-1 on the surface of infected red blood cells to endothelial ...
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In vitro inhibition and reversal of Plasmodium falciparum cytoadherence to endothelium by monoclonal antibodies to ICAM 1 and CD36
... Background: Sequestration of parasitized red blood cells from the peripheral circulation during an infection with Plasmodium falciparum is caused by an interaction between the parasite protein PfEMP1 and receptors ...
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In vitro inhibition and reversal of Plasmodium falciparum cytoadherence to endothelium by monoclonal antibodies to ICAM 1 and CD36
... Background: Sequestration of parasitized red blood cells from the peripheral circulation during an infection with Plasmodium falciparum is caused by an interaction between the parasite protein PfEMP1 and receptors ...
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Automated counting for Plasmodium falciparum cytoadherence experiments
... One of the major challenges for malaria cytoadherence assays has been the counting. These assays are also notoriously variable, requiring several replicates that add to this burden. In this paper we have ...
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Atorvastatin prevents Plasmodium falciparum cytoadherence and endothelial damage
... These data suggest that atorvastatin increases the Akt expression within endothelial cells. The data presented here demonstrate that atorvastatin can be used to reduce the cytoadherence of P. falciparum on ...
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Broad inhibition of Plasmodium falciparum cytoadherence by (+)-epigallocatechin gallate.
... existing cytoadherence rather than just inhibition of new binding and testing the compound for disruption of ICAM-1-dependent IE binding in the context of endothelial ...
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carbon sequestration
... Initial treatment and maintenance costs contribute to the overall costs of a carbon sequestration program. The U.S. Forest Service maintains extensive records on the costs of domestic afforestation and ...
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INTRODUCTION SEQUESTRATION IMPACTS
... requirements. Sequestration could also have significant impact on the DNS organization because it could cause reductions in resource allocation across all functional areas in the security ...
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Imaging in bronchopulmonary sequestration
... the sequestration is removed after birth via ...the sequestration, and a laser fiber is targeted at the abnormal blood vessel going to the ...the sequestration, causing it to stop ...the ...
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Carbon sequestration in the agroecosystem
... Reduction of amount CO 2 is possible by carbon sequestration to the soil. Fixation potential of EU–15 agricultural land is c. 16–19 mil t C . year −1 . Amount and composition of post–harvest residues is es- ...
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