Serotonin transporter (SERT)
Altered inflammatory responsiveness in serotonin transporter mutant rats
... the SERT gene that is associ- ated with enhanced vulnerability to depressive disorders ...the serotonin transporter show, when compared to LL carriers, a proinflammatory phenotype, measured as the ...
10
Child Maltreatment Influences Methylation Density of Serotonin Transporter Gene (5HTTLPR) Depending on Genotype
... However, some meta-analyses have not supported the interaction effect of the short variant of the serotonin transporter and environmental adversity (Munafò, Durrant, Lewis & Flint, 2009; Risch et al., ...
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INFLUENCE OF SEROTONIN TRANSPORTER-LINKED POLYMORPHIC REGION (5-HTTLPR) VARAINTS ON CLINICAL OUTCOMES IN THAI PATIENTS WITH DEPRESSIVE DISORDER
... of serotonin transporter polymorphism and clinical outcomes (Thai HRS-D score, psychiatrist evaluation and side effects) were investigated by Chi-square ...
5
Alteration of serotonin transporter density and activity in fibromyalgia
... platelet SERT is altered. Our previous studies demonstrated an alteration of SERT density and of the uptake rate of SERT in psychiatric patients ...of SERT on platelet membranes, the higher ...
6
Molecular and functional characterization of the Gulf toadfish serotonin transporter SLC6A4
... elevated SERT in the toadfish liver could be linked to a role in 5-HT ...of SERT expression and 5-HT production in the liver could enable the regulation of synthesized 5-HT and its movement to other ...and ...
11
Neuroinflammation and amyloid-beta 40 are associated with reduced serotonin transporter (SERT) activity in a transgenic model of familial Alzheimer’s disease
... elevated SERT immunoreactivity has been observed by 3 months of age, ...of SERT, which may decrease the level of extracellular 5-HT, contrast the degenerative reductions in the levels of several ...
13
Polymorphisms of serotonin transporter gene and psychological status in patients with multiple sclerosis
... flare-ups. Serotonin transmission is modified in some brain regions of patients with MS, and these changes may contribute to their psychiatric ...the serotonin reuptake transporter (SERT) gene ...
6
Beneficial effects of trimetazidine on expression of serotonin and serotonin transporter in rats with myocardial infarction and depression
... Trimetazidine has been used clinically as long-term treatment of myocardial ischemia, but there is currently a lack of in- depth understanding of the mechanism by which it works for this purpose. In this experiment, we ...
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Impulsivity, gender, and the platelet serotonin transporter in healthy subjects
... the SERT promoter polymorphism (SLC6A4*C), a blunted fenfluramine-induced prolactin release and aggres- sive impulsivity, in a group of abstinent alcoholic patients and healthy volunteers, while suggesting that ...
7
Lower serotonin transporter binding in patients with cervical dystonia is associated with psychiatric symptoms
... between SERT and DAT binding influences the motor phenotype of CD, more specifically whether a patient develops jerks or ...striatal SERT/DAT ratio was higher in PD patients suffering Table 2 Regression ...
7
Polymorphisms of the serotonin transporter and receptor genes: susceptibility to substance abuse
... Abstract: Serotonin (5-hydroxytryptamine [5-HT]) is an important neurotransmitter implicated in regulating substance-use disorder (SUD) acquisition, maintenance, and ...5-HT transporter-linked poly- morphic ...
9
Association of serotonin and dopamine gene pathways with behavioural subphenotypes in dementia
... the serotonin transporter gene (SERT) polymorphism STin2 and “psychosis”; the dopamine transporter gene (DAT) 3= variable number tandem repeats (VNTR) and “agitation”; and the dopamine ...
13
dat sar 2 beta substituted tropanes pdf
... the serotonin transporter (SERT), norepi- nephrine transporter (NET), and muscarinic receptors and compared to the parent ligands 2 and 3 (Table ...or SERT as did compound ...over ...
9
SERT-to-DAT ratios in early Parkinson’s disease do not correlate with the development of dyskinesias
... Methods: Between 1995 and 1998, 50 patients with early-stage untreated PD, diagnosed according to clinical criteria, and reduced striatal [ 123 I] β -carboxymethyoxy-3-beta-(4-iodophenyl) tropane (CIT) single-photon ...
7
Psychogenetics of post-traumatic stress disorder: a short review
... An interesting and innovative study was carried out by an Australian team to assess whether a polymorphism of serotonin transporter gene (SLC6A4) may potentially affect response to cognitive behavioral ...
6
Borderline personality disorder and childhood trauma: exploring the affected biological systems and mechanisms
... Dopamine Transporter 1 (DAT1), Gamma-Aminobutyric Acid Type A Receptor Alpha1 Subunit (GABRA1), G Protein Subunit Beta 3 (GNB3), Glutamate Ionotropic Receptor NMDA Type Subunit 2B (GRIN2B), 5-Hydroxytryptamine ...
14
Understanding the nature of psychiatric comorbidity in migraine: a systematic review focused on interactions and treatment implications
... 5-HT: Serotonin; 5-HTTLPR: Serotonin-transporter-linked polymorphic region; BD: Bipolar disorder; CBCL: Child Behavior Checklist; CBT: Cognitive- behavioral therapy; CGRP: Calcitonin gene-related ...
17
Lack of association between COMT gene polymorphism and treatment outcome in major depression
... Meta- analysis of serotonin transporter gene promoter polymorphism (5-HTTLPR) association with selective serotonin reuptake inhibitor efficacy in depressed patients.[r] ...
6
Freeman_unc_0153D_12981.pdf
... the serotonin transporter gene (SLC6A4) has recently garnered attention as one such potential candidate genetic polymorphism (anomaly) (Cho, et ...The serotonin transporter is a logical ...
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Effect of the probiotic Lactobacillus plantarum IS-10506 on BDNF and 5HT stimulation: role of intestinal microbiota on the gut-brain axis
... Materials and Methods: The animals were divided into two groups: one received L. plantarum IS strain 10506 supple- mentation, while the control group received no treatment. Activation of the gut–brain axis was evaluated ...
6