Serum tryptase
Assessment of Serum Tryptase Activity Among Acute and Chronic Myeloid Leukemia Patients Visiting Hematology-Oncology Clinic at TikurAnbessa Specialized Hospital, and Comparison with Healthy Controls
... Abstract: Tryptase is a serine protease that is expressed in leukemic cells of chronic myeloid leukemia (CML) patients and in blasts of acute myeloid leukemia (AML) ...patients. Tryptase may be useful for ...
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Mast cells and acute coronary syndromes: relationship between serum tryptase, clinical outcome and severity of coronary artery disease
... measured serum tryptase at admission in 140 consecutive patients with ACS and in 50 healthy ...of serum tryptase for 2-year MACCE was assessed and compared with hs-Tn, CRP and SYNTAX ...
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Non-steroidal anti-inflammatory drug hypersensitivity: association with elevated basal serum tryptase?
... basal serum tryptase levels of > 10 ...with serum tryptase levels of > 20 ng/mL had moderate (grade 2) anaphylaxis not requiring adrenaline, while the remaining 4 patients experienced ...
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Serum tryptase detected during acute coronary syndrome is significantly related to the development of major adverse cardiovascular events after 2 years
... Therefore, in the present study, we analyzed the correl- ation between the development of MACE and some angiographic and clinical parameters, such as SX-score and cardiovascular complexity, and the previously eva- luated ...
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The significance of diagnosing associated clonal mast cell diseases in patients with venom-induced anaphylaxis and the role of bone marrow investigation
... Presently, the diagnosis of HVA is based on clinical history, skin prick test and allergen-specific IgE [10]. Moreover, the measurement of baseline serum tryptase (sBT) has opened the possibility to screen ...
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Long-term treatment with imatinib results in profound mast cell deficiency in Ph+ chronic myeloid leukemia
... Although mast cells (MC) play an important role in allergic reactions, their physiologic role remains unknown. In mice, several models of MC-deficiency have been developed. However, no comparable human model is ...
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Dengue virus–elicited tryptase induces endothelial permeability and shock
... of tryptase at picomolar concen- trations and also approved for clinical use for intravascular coag- ulation (42, ...of tryptase and chymase activi- ties in the serum of mice from each experimental ...
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Vol 27, No 2 (2017)
... elevated serum tryptase levels, and the presence of mast cells in the papillary dermis histopathologically, the diagnosis of urticaria pigmentosa was ...
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Simplified tooth movement with mini implants and orthodontic elastics: A prosthodontic approach
... rupture. Tryptase activates matrix metalloproteinases (MMP), such as MMP-1, MMP-2 and MMP-3 and procollagenase, and promotes the degradation of lipoproteins and fibronectin 21,22 , acting as powerful inflammatory ...
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Stinging insect allergy: current perspectives on venom immunotherapy
... Predictors of severe systemic anaphylactic reactions in patients with Hymenoptera venom allergy: importance of baseline serum tryptase-a study of the European Academy of All[r] ...
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The alpha form of human tryptase is the predominant type present in blood at baseline in normal subjects and is elevated in those with systemic mastocytosis
... and tryptase in blood from normal and nonacute mastocytosis subjects, and binds with high affinity to recombinant beta-tryptase, tryptase in serum during anaphylaxis, and tryptase ...
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Effect of tryptase on mouse brain microvascular endothelial cells via protease-activated receptor 2
... Fig. 3 Tryptase upregulates the production of VCAM-1 via PAR-2. Mouse brain microvascular endothelial cell were pre-treated with FS at 400 μ M for 30 min and then stimulated with tryptase at 1 μ g/mL for 24 ...
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Adam, Marion (2011): Regulation and functional signaling of decorin in the testis in health and disease. Dissertation, LMU München: Fakultät für Biologie
... DCN was detected in conditioned media (3 days) using a commercial enzyme-linked immunosorbent assay (ELISA). Medium supernatants (total 2 ml per 60-mm dish) of the same tryptase/SLIGKV- treated and untreated ...
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Original Article Tryptase and TIM-1 double-positive mast cells in different stages of human chronic periodontitis
... goat serum and 1% bovine serum albumin (BSA) (pH ...anti-MC tryptase mouse monoclonal antibody (AA1, IgG1; 1 mg/ml, 1:200 dilution; Abcam, UK) overnight at ...
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Mast cells positive to tryptase, endothelial cells positive to protease-activated receptor-2, and microvascular density correlate among themselves in hepatocellular carcinoma patients who have undergone surgery
... Tryptase is an agonist of PAR-2 in vascular ECs, which stimulates their proliferation. Signaling via PAR-2 on ECs elicits activation of the major members of the mitogen-activated protein kinase phosphorylation ...
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Time course of appearance and disappearance of human mast cell tryptase in the circulation after anaphylaxis
... of tryptase in the circulation after an anaphylactic event and the stability of both endogenous and exogenous tryptase in terms of freeze-thawing and ...of tryptase after an experimentally induced ...
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Tryptase Clara, an activating protease for Sendai virus in rat lungs, is involved in pneumopathogenicity.
... Since postulated previously lung lesions asClara antibody was shown to suppress viral anti-tryptase activation in the lungs to 10 to 20% of the activation in the control rats, it is conc[r] ...
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Immunohistochemical Expression of Mast Cell in Oral Reactive Lesions
... tongue (2%), respectively. The mean tryptase-positive mast cell count was 28.1±10.4 in POF, 23.5±7.9 in PGCG, 18.9±8.1 in irritation fibroma, and 13.7±4.2 in normal oral mucosa (Figure 1). Using variance analysis, ...
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Enhanced release of IgE-dependent early phase mediators from nasal polyp tissue
... of tryptase positive cells, in both nasal polyps and inferior turbinates, which may be explained by the staining of other than mast cells, such as basophils, eosinophils [25] and dendritic cells ...
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A Functional Proteomics Screen of Proteases In Colorectal Carcinoma
... B. Tryptase activity was assayed in normal and high-salt colon tissue extracts with 50 M BOC-Ala-Gly-Pro- Arg-AMC (Enzyme Systems Products) in 50 mM Tris HCl, pH ...
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