serum urate
Untangling the complex relationships between incident gout risk, serum urate, and its comorbidities
... once serum urate level was accounted ...in serum urate, which is consistent with the result that serum urate mediates this relation- ship with incident gout [33, ...
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Prescription and dosing of urate lowering therapy, rather than patient behaviours, are the key modifiable factors associated with targeting serum urate in gout
... A total of 273 patients attended the study visit. There were 89 (32.6%) patients with serum urate level <0.36 mmol/L (‘at SU target’ group). The clinical charac- teristics are shown for all patients in ...
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Interactions between serum urate associated genetic variants and sex on gout risk: analysis of the UK Biobank
... in serum urate would strengthen the findings of our ...However, serum urate measurements are not currently available in the UK Biobank ...
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Body mass index modulates the relationship of sugar sweetened beverage intake with serum urate concentrations and gout
... on serum urate in separate body mass index strata was assessed by analysing 12,870 people without gout from the Atherosclerosis Risk in Communities (ARIC), Framingham Heart Study (FHS) and New Zealand (NZ) ...
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Positive association of tomato consumption with serum urate: support for tomato consumption as an anecdotal trigger of gout flares
... Data from the Atherosclerosis Risk in Communities (ARIC) (http://www2.cscc.unc.edu/aric/), Cardiovascu- lar Health Study (CHS) (https://chs-nhlbi.org/) and Framingham Heart Study (FHS) Generation 3 (http:// ...
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The role of diet in serum urate concentration.
... in serum urate associated with secondary causes such as kidney disease and diuretics, which are likely to have significant influence in clinical populations, so as to understand the relative contributions ...
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What lies behind serum urate concentration? Insights from genetic and genomic studies
... into urate overproduction type, underexcretion type, and mixed ...However, urate excretion is the major factor in the regulation of serum urate concentrations, supported by the results of ...
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Physiologic Determinants of Serum Urate Levels in Adolescence
... Other physiological variables, blood pressure and cholesterol, have significant relationships to urate levels but make relatively minor indepen- dent contributions to the explanation of [r] ...
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Patient considerations in the management of gout and role of combination treatment with lesinurad
... accepted serum urate target level is < 6 mg/dL. However, a lower serum urate target of < 5 mg/dL is a consideration for patients with severe gout who need fast dissolution of ...
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A new concept for urate in human serum: Enzymatic assay of total urate (protein bound & loosely associated) in serum using 3,5 dichloro 2 hydroxybenzenesulphonic acid/4 aminophena zone chromogenic system
... of serum urate, some of the lactim toutomer (PBU) will be liberated from proteins slowly and rearranged to the lactam toutomer to stabilize the state of equilibrium, The resulted lactam will be involved in ...
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A Composite Endpoint Measure to Consolidate Multidimensional Impact of Treatment on Gouty Arthritis
... (e.g. serum urate levels versus categorical responses to self-reported pain measures), a common metric needs to be ...in urate levels could each be response ...
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aime201701030-m160570.pdf
... reduced urate levels, no study examined the effect of any dietary intervention on clinical outcomes, such as acute gout ...on serum urate levels in patients with ...
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Recurrent EIARF and PRES With Severe Renal Hypouricemia by Compound Heterozygous SLC2A9 Mutation
... which would have explained the pa- tient’s low serum urate level of 5.9 mol/L (0.1 mg/dL). GLUT9S cooper- ates with URAT1 on the apical side of the tubule. Therefore, mutations of the URAT1 gene, even in ...
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URIC ACID PRODUCTION IN GOUT
... Since the salivary excretion of uric acid gouty, and hyperuricemic subjects by measmal, is increased with the elevation of serum urate levels 22, the gouty subject should show, if uring [r] ...
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The relationship between ferritin and urate levels and risk of gout
... the serum ferritin versus serum urate/gout/flares ...with serum urate levels, the risk of gout and the number of self-reported flares and cannot be used to claim that this association ...
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Risk factors for incident hyperuricemia during mid adulthood in African American and White men and women enrolled in the ARIC cohort study
... baseline serum urate level (n = 77) because we were unsure whether or not they had hyperuricemia at ...subsequent urate measure were not included in this study (n = ...missing serum or plasma ...
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Association of the lipoprotein receptor related protein 2 gene with gout and non additive interaction with alcohol consumption
... Regression analysis was used to investigate relationships between the variables in this study. For continuous re- sponse variables, this involved standard linear regression. For binary response variables (that is, ...
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Recurrent exercise-induced acute kidney injury by idiopathic renal hypouricemia with a novel mutation in the SLC2A9 gene and literature review
... 4. Stiburkova B, Sebesta I, Ichida K, Nakamura M, Hulkova H, Krylov V, Kryspinova L, Jahnova H: Novel allelic variants and evidence for a prevalent mutation in URAT1 causing renal hypouricemia: biochemical, genetics and ...
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Guideline development for the management of gout: role of combination therapy with a focus on lesinurad
... if serum urate (SUA) target has not been met by appropriate or optimal dosing of a xanthine oxidase ...urinary urate excretion should be assessed prior to starting ...
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Single Nucleotide Polymorphisms (SNPs) of URAT1 (rs7932775) and ABCG2 (rs3825016) on Chronic Kidney Disease Patients with Hyperuricemia
... of urate excretion in the control of serum urate levels and the risk of gout and have identified the kidneys, the gut and the liver as sites of urate ...Human urate transpor- ter 1 ...
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