Severe exacerbation
Serum sST2 levels predict severe exacerbation of asthma
... [23]. We assessed asthmatic patients who were recruited irrespective of atopic state and demonstrated that serum sST2 levels at steady state also correlated with disease severity (i.e. treatment step) and that serum sST2 ...
10
Prediction and course of symptoms and lung function around an exacerbation in chronic obstructive pulmonary disease
... an exacerbation, 48 were labeled as treatment failures and excluded from further analyses as they suffered from a new exacerba- tion within 8 weeks after the onset of the first exacerba- ...or severe ...
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Impact and prevention of severe exacerbations of COPD: a review of the evidence
... of severe exacerbations remains a significant unmet need in ...of severe exacerbations in patients with COPD at all stages of ...preventing severe exacerbations of ...of severe exacerbations ...
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<p>A Nomogram for Predicting Severe Exacerbations in Stable COPD Patients</p>
... Any exacerbation of COPD was a report of worsen- ing respiratory symptoms needing additional ...therapy. Severe exacerbation was de fi ned as a patient suffering from an acute episode of respiratory ...
10
A randomised pragmatic trial of corticosteroid optimization in severe asthma using a composite biomarker algorithm to adjust corticosteroid dose versus standard care: study protocol for a randomised trial
... protocol-defined severe exacerbations per patient per year, time to first severe exacerbation from randomisation, dose of inhaled steroid at the end of the study, cumulative dose of inhaled ...
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Exacerbation-related impairment of quality of life and work productivity in severe and very severe chronic obstructive pulmonary disease
... Several limitations of this study should be noted. The results will be most generalizable to similar patient popu- lations, that is, patients with severe or very severe COPD within the US population, who ...
12
<p>Mixed Phenotype of Emphysema and Airway Wall Thickening Is Associated with Frequent Exacerbation in Chronic Obstructive Pulmonary Disease Patients</p>
... experiencing exacerbation of COPD ...with severe exacerbation frequency in univari- ate ...with severe exacerbation ...frequent severe exacerbation (IRR ...
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Spirometric changes during exacerbations of COPD: a post hoc analysis of the WISDOM trial
... moderate/severe exacerbation between Week 12 (the time of complete ICS withdrawal) and Week 52; 182 patients experienced severe ...moderate/severe exacerbation, a total of 360 patients ...
7
Single-inhaler triple therapy in patients with chronic obstructive pulmonary disease: a systematic review
... prior exacerbation frequency subgroup, triple therapy demonstrated a higher reduction in the rate of moderate and severe exacerbations in patients with a history of more exacerbations than those who experi- ...
13
El Sawy
... asthma exacerbation is the most common cause of childhood emergency department visits and ...one severe exacerbation in the prior year have a two folds increased risk of subsequent severe ...
6
Impacts of coexisting bronchial asthma on severe exacerbations in mild-to-moderate COPD: results from a national database
... had severe exacer- bations over the 6 years (0.012/person-year). Severe exacerbations were more frequent in the COPD patients with concomitant self-reported physician-diagnosed asthma compared with only ...
9
A randomised pragmatic trial of corticosteroid optimization in severe asthma using a composite biomarker algorithm to adjust corticosteroid dose versus standard care: study protocol for a randomised trial
... protocol-defined severe exacerbations per patient per year, time to first severe exacerbation from randomisation, dose of inhaled steroid at the end of the study, cumulative dose of inhaled ...
13
Severe asthma exacerbation: role of acute Chlamydophila pneumoniae and Mycoplasma pneumoniae infection
... Acute exacerbation of bronchial asthma (AEBA) was defined as following: episodes of rapidly progressive increase in shortness of breath, cough, wheezing, or chest tightness, or some combination of these symptoms ...
6
The SYGMA programme of phase 3 trials to evaluate the efficacy and safety of budesonide/formoterol given ‘as needed’ in mild asthma: study protocols for two randomised controlled trials
... annualised severe exacerbation rate; 4114 patients (2057 patients/treatment group) were estimated to be re- quired to achieve 90% power to detect a difference in annualised severe asthma ...
13
<p>Greater eosinophil counts at first COPD hospitalization are associated with more readmissions and fewer deaths</p>
... first severe exacerbation of COPD, when assessed in a time frame free of systemic corticosteroids, was associated with a significant increase in 1-year readmission for COPD and a shorter time to first ...
11
Respiratory Manifestations of Food Allergy
... These specific mediators can also contribute to late-phase allergic reactions that occur 4 to 8 hours after an immediate allergic response. Mast cell-de- rived mediators can cause endothelial cells to up- regulate their ...
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A Task-based Support Architecture for Developing Point-of-care Clinical Decision Support Systems for the Emergency Department
... Diagnostic accuracies of MET3-AE and the ED medical staff are given in Table IV. When computing sensitivity and specificity we labeled the class combining moderate and severe exacerbations as the positive one (in ...
41
Determinants of change in physical activity during moderate-to-severe COPD exacerbation
... the exacerbation and those reflecting the general clinical con- dition of the patient influence changes in the level of PA, especially among those admitted to hospital from the ...
11
Prediction of severe acute exacerbation using changes in breathing pattern of COPD patients on home noninvasive ventilation
... AECOPD that could be explained by the fact that 38% of our cohort of patients who had a severe AECOPD had con- comitant obstructive sleep apnea. Rostral fluid distribution is known to increase apneic events. In ...
10
Clinical presentation and predictors of outcome in patients with severe acute exacerbation of chronic obstructive pulmonary disease requiring admission to intensive care unit
... Criteria for intubation were not standardized, and nonin- vasive ventilation was infrequently utilized at our hospital during the period of study. Endotracheal intubation and assisted mechanical ventilation were ...
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