Severe hemophilia A
Review of antihemophilic factor injection for the routine prophylaxis of bleeding episodes and risk of joint damage in severe hemophilia A
... Nonrandomized as well as randomized studies have accu- mulated a plethora of data on prophylactic FVIII infusions in patients with severe hemophilia A, documenting the beneficial results of decreased ...
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Cost–utility analysis of prophylaxis versus treatment on demand in severe hemophilia A
... Methods: A Markov model was developed and run using different sources of clinical, cost, and utility data. The model was populated with a hypothetical cohort of 100 individuals with severe hemophilia A. The ...
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Challenges and successes in the treatment of hemophilia: the story of a patient with severe hemophilia A and high-titer inhibitors
... with severe hemophilia have suffered a substantially reduced quality of life with frequent bleeding episodes, disabling arthropathy, and shorter life ...a severe hemophiliac through examination of ...
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To study the occurrence of inhibitors in children affected with hemophilia ‘A’ and hemophilia ‘B’ disease
... screen hemophilia affected patients for the presence of ...100 hemophilia A and B patients were screened for the presence of inhibitors to Factor VIII and Factor ...100 hemophilia patients screened ...
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Recombinant factor VIII in the management of hemophilia A: current use and future promise
... into severe (1% of normal circulating factor VIII activity), moderate (1%–4%), and mild ...with severe hemophilia A were treated when sponta- neous or traumatic bleeding episodes occurred, a style ...
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“Cost of Illness Patients with Hemophilia in RSUP Dr. Sardjito Yogyakarta” by Umi Nafisah, Satibi, Diah Ayu Puspandari, Indonesia.
... of Hemophilia based on the hospital perspective, to know the difference between the cost of illness patients with hemophilia A and hemophilia B, to investigate the effect of the inhibitor on the cost ...
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Rituximab for Treatment of Hemophilia A with High-Responder Inhibitors
... with severe hemophilia A with inhibitor titer ≥5 Bethesda Units/ml (BU) during 100 weeks in comprehensive hemophilia care center in Imam Khomeini ...No severe allergic reaction was ...
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<p>Health-related quality-of-life and treatment satisfaction of individuals with hemophilia A treated with turoctocog alfa pegol (N8-GP): a new recombinant extended half-life FVIII</p>
... Pathfinder™2 (NCT01480180) was a phase III, mul- ticenter, multinational, open-label, non-randomized trial. Patients enrolled in pathfinder™2 were $12 years of age with severe hemophilia A (,1 % FVIII), had ...
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Issues in pediatric haemophilia care
... of severe hemophilia A patients and in only 3-5% of those with hemophilia B, render replacement therapies ineffective ...with hemophilia: host predisposition to FVIII inhibitors has been ...
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... National Hemophilia Treatment Center in March- September ...with severe hemophilia A (factor VIII <1%), history of repeated joint bleeds, and previously received episodic ...
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Prevalence of Inhibitors in Patients with Hemophilia Treated with Factor VIII or IX Transfusion in Coimbatore Medical College Hospital
... Results from the study showed that inhibitor development were more common in severe hemophilia A than severe hemophilia B .Patients with more number of cumulative exposure days, earlier [r] ...
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Desensitization and immune tolerance induction in children with severe factor IX deficiency; inhibitors and adverse reactions to replacement therapy: a case-report and literature review
... with severe hemophilia A but only 1-3% of those with hemophilia B ...of severe hemophilia B results from missense mutations [8], providing an in- creased proportion of antigenic ...
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Antihemophilic factor (recombinant) plasma/albumin-free method for the management and prevention of bleeding episodes in patients with hemophilia A
... To assess the clinical response to therapy, 2 populations of patients with hemophilia are normally studied: previously untreated patients (PUPs) and previously treated patients (PTPs). Factor replacement regimens ...
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The value of usability testing for Internet-based adolescent self-management interventions: “Managing Hemophilia Online”
... We wish to thank all of the adolescents who participated in this study and the health care providers at both sites for their cooperation. We also wish to acknowledge AboutKidsHealth.ca for their role in the development ...
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Acquired Hemophilia A in an advanced age patient of hispanic origin: a case report
... To confirm the presence of AHA, the clinical indica- tions must be exhibited in addition with the specialized laboratory testing such as the Factor VIII inhibitory assay and Bethesda Unit quantification assay [7]. ...
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Circumcision in hemophilia using low quantity of factor concentrates: experience from Dakar, Senegal
... Many types of alternative protocols was used in various studies [14, 23, 24]. Al these protocols have the same ob- jectives to reduce or prevent bleeding events of circumci- sion. These studies show that the absence or ...
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<p>Mild-severe hemophilia B impacts relationships of US adults and children with hemophilia B and their families: results from the B-HERO-S study</p>
... that hemophilia affected their ability to form close relationships with partners or prospective partners; 35% were very/quite dissatis fi ed with the support received from a previous ...their hemophilia ...
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Use of Prothrombin Complex Concentrates in Hemophiliacs with Inhibitors: Clinical and Laboratory Studies
... Nine patients with severe classic hemophilia and inhibitors against factor VIII were treated for 156 bleeding episodes with 503 infusions of Proplex, Konyne, or.. Auto-Factor IX, three p[r] ...
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VASCULAR HEMOPHILIA
... The effect of transfusion of fresh-frozen normal plasma (225 ml) on bleeding time, clotting time, prothrombin consumption, and thromboplas- tin generation of patient T.H. Demonstration o[r] ...
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Treatment adherence in hemophilia
... Strategies are needed to align prophylaxis recommenda- tions with patients’ goals and skills. Types of interventions may include educational, cognitive/behavioral, and skill training (Table 3). These approaches need to ...
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