SH-SY5Y
On the cytotoxicity of HCR NTPase in the neuroblastoma cell line SH SY5Y
... Consequently, a mutant protein lacking this essential glutamate is expected to be catalytically inactive. Such a mutant was then suitable to decide whether unspecific intracellular hydrolysis of nucleotides or the ...
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Neuroprotective Effects of Methyl 3,4-Dihydroxybenzoate Against TBHP-Induced Oxidative Damage in SH-SY5Y Cells
... To further explore the molecular mechanisms of neuroprotective effect of MDHB on THBP- induced oxidative damage, we examined the expression of Bcl2, Bax, caspase-3, p-Akt and Akt in SH- SY5Y cells by ...
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The Role of Neurotransmitters in Protection against Amyloid β Toxicity by KiSS 1 Overexpression in SH SY5Y Neurons
... 3.2. Neuroprotection against Amyloid-𝛽 by KiSS-1 Overex- pression and the Role of Kisspeptin. The overexpression of the KiSS-1 gene in SH-SY5Y neurons was shown to be significantly (𝑃 < 0.0001; one-way ...
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Coffee Modulates the Function of Brain Derived Neurotrophic Factor (BDNF) in Human Neuroblastoma SH SY5Y Cells
... Recent epidemiological studies showed that daily coffee consumption is associated with a lower risk for several neurological disorders such as Alzheimer’s disease and Parkinson’s disease; how- ever, the molecular ...
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miR-186-5p Promotes Apoptosis by Targeting IGF-1 in SH-SY5Y OGD/R Model
... miR-186-5p has been found to play dual roles either as an oncogene or a tumor suppresser gene in several kinds of cancers[12]. For example, in NSCLC cells, miR-186-5p suppresses tumor proliferation by regulating cyclin ...
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Original Article Lentivirus-mediated silencing of HSP70 aggravated hypoxia-induced apoptosis in SH-SY5Y cells
... of SH-SY5Y cells induced by hypoxia. SH-SY5Y cells are derived from SK-N-SH cell line, and have the ability of adhesion and proliferation ...culture, SH-SY5Y is easy to ...
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The Role of Neurotransmitters in Protection against Amyloid β Toxicity by KiSS 1 Overexpression in SH SY5Y Neurons
... 3.2. Neuroprotection against Amyloid-𝛽 by KiSS-1 Overex- pression and the Role of Kisspeptin. The overexpression of the KiSS-1 gene in SH-SY5Y neurons was shown to be significantly (𝑃 < 0.0001; one-way ...
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Edible bird’s nest ameliorates oxidative stress induced apoptosis in SH SY5Y human neuroblastoma cells
... exposing SH-SY5Y cells to neurotoxin 6-hydroxydopamine ...on SH-SY5Y cells was tested using MTT ...cause SH-SY5Y cell death at concentrations up to 75 μ g/ml while the maximum ...
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Original Article Isatin inhibits SH-SY5Y neuroblastoma cell invasion and metastasis through PTEN signaling
... in SH-SY5Y cells, wherein H3K4m1 acts as a sub- strate of ...on SH-SY5Y cells by increasing the expression level of H3K4m1, which then activates PTEN signaling through the inhibition of LSD1 ...
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Evaluation of the Anti-apoptotic and Anti-cytotoxic Effect of Epicatechin Gallate and Edaravone on SH-SY5Y Neuroblastoma Cells
... bated for 1 h into SH-SY5Y cells, which were split in the 96-well plates at a density of 1.0×104 /well (IC50 concentration was calculated for each of these materi- als) (Yew et al., 2014). They were then ...
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Neuroprotective effects of melittin on hydrogen peroxide induced apoptotic cell death in neuroblastoma SH SY5Y cells
... 19. Zhang L, Yu H, Sun Y, Lin X, Chen B, Tan C, Cao G, Wang Z: Protective effects of salidroside on hydrogen peroxide-induced apoptosis in SH-SY5Y human neuroblastoma cells. Eur J Pharmacol 2007, 564:18 – ...
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Original Article Lidocaine hydrochloride increased apoptosis of SH-SY5Y cells through p38 MARK mediated DNA methylation
... MeCP2 releases transcription inhibiting com- pound from methylated genes to let transcrip- tion factor to connect with promoter so as to activate transcription [25, 26]. Our study de- tected obvious mitigation of DNA ...
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BACE-1 inhibition prevents the γ-secretase inhibitor evoked Aβ rise in human neuroblastoma SH-SY5Y cells
... In our first set of experiments, we were able to verify that LY450139 increases both Ab40 and Ab42 levels at a low concentration in SH-SY5Y APPwt cells but not in SH-SY5Y APPswe cells. At ...
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Loss of the Chr16p11.2 ASD candidate gene QPRT leads to aberrant neuronal differentiation in the SH-SY5Y neuronal cell model
... of SH-SY5Y wild-type cells [28] to the morphological changes during neuronal differentiation described in the present study, we found QPRT to be correlated with the development of the neuritic ...of ...
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Additive Protective Effects of Luteolin and Pyruvate against 6 Hydroxydopamine and 3 Hydroxykynurenine Induced Neurotoxicity in SH SY5Y Cells
... neuroblastoma SH-SY5Y ...in SH-SY5Y cells may be related to two differ- ent neuroprotective mechanisms and the capability to penetrate into the ...
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Neuroprotective effects of Paeonia Lactiflora extract against cell death of dopaminergic SH SY5Y cells is mediated by epigenetic modulation
... differentiated SH-SY5Y cells was significantly reduced by PLE pretreatment in a dose- dependent manner, accompanied by induced expression of ...dopaminergic SH-SY5Y cells via upregulation of ...
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Dephosphorylation of myristoylated alanine rich C kinase substrate accelerates wound induced migration of SH SY5Y cells
... We have reported that MARCKS is phosphorylated by both PKC and ROCK in SH-SY5Y cells [8]. We per- formed wound healing assay under the condition when ROCK inhibitor HA-1077 or PKC inhibitor Ro-31-8220 ...
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In vitro neuroprotective potential of four medicinal plants against rotenone induced toxicity in SH SY5Y neuroblastoma cells
... Four herbal remedies which are either traditionally reported to be used in the treatment of neurological dis- orders or which are implicated in neurological disorders were selected for investigation. Infusions of the ...
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<p>Liraglutide Attenuates Aβ42 Generation in APPswe/SH-SY5Y Cells Through the Regulation of Autophagy</p>
... inhibitor 3-MA. Based on our fi ndings, we hypothesize that the reduction of A β 42 generation by liraglutide might through enhancing autophagy in APPswe/SH-SY5Y cells. Recently, more attention has been paid ...
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<p>Andrographolide attenuates bupivacaine-induced cytotoxicity in SH-SY5Y cells through preserving Akt/mTOR activity</p>
... on SH-SY5Y cells was signi fi cantly alleviated by Andro (100 or 200 μ M) ...in SH-SY5Y ...Bup-treated SH-SY5Y cells was about 10% and ...Bup-treated SH-SY5Y cells ...
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