SH-SY5Y cell model
Effects of Hypothermic Temperatures on Tau Hyperphosphorylation as a Model of Alzheimer’s Disease in SH-SY5Y Cells
... maintain cell structure by regulating the stabilization of microtubules, but have also been linked to progressive neurodegeneration under pathological conditions (Kong, ...in cell death and associated ...
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Differentiated Human SH-SY5Y Cells Provide a Reductionist Model of Herpes Simplex Virus 1 Neurotropism
... differentiated SH-SY5Y neuronal ...differentiated SH-SY5Y neuronal cells than in the undifferentiated progenitor ...neuronal SH-SY5Y ...neuronal SH-SY5Y cells, ...
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miR-186-5p Promotes Apoptosis by Targeting IGF-1 in SH-SY5Y OGD/R Model
... OGD10h/R model, among which hsa-miR-186-5p was the most ...use SH-SY5Y cells to build an OGD/R model in vitro to mimic ischemia and ...inducing SH-SY5Y cell apoptosis is ...
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SH-SY5Y-derived neurons: A neuronal model system for investigating TAU sorting mechanisms and neuronal subtype-specific TAU vulnerability
... human-derived SH-SY5Y neuroblastoma cell line is widely used for studying TAU physiology and TAU-related pathology in Alzheimer’s disease (AD) and related ...tauopathies. SH-SY5Y cells ...
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Original Article Establishing cell model of herpes simplex virus type 2 latent infection and reactivation in SH-SY5Y cells
... establish cell model of herpes simplex virus type 2 latent infection and reactivation in SH- SY5Y ...on SH-SY5Y cells were observed after cells were treated with ACV concentra- ...
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Cell Creeping and Controlled Migration by Magnetic Carbon Nanotubes
... the cell culture medium induce cell migration towards a permanent ...a model of cell movement based on the theory of bond survival postulated by Bell in ...The model parameters, ...per ...
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Loss of the Chr16p11.2 ASD candidate gene QPRT leads to aberrant neuronal differentiation in the SH-SY5Y neuronal cell model
... of SH-SY5Y wild-type cells [28] to the morphological changes during neuronal differentiation described in the present study, we found QPRT to be correlated with the development of the neuritic ...KO ...
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Increasing the TRPM2 Channel Expression in Human Neuroblastoma SH-SY5Y Cells Augments the Susceptibility to ROS-Induced Cell Death
... in SH-SY5Y cells is critical for the question of whether or not this human cell model can be used to gain insights into the molecular and signaling mechanisms for TRPM2-dependent ...
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Expression of a Cu,Zn superoxide dismutase typical for familial amyotrophic lateral sclerosis increases the vulnerability of neuroblastoma cells to infectious injury
... in-vitro model to study the cellular alterations associated with mutations of SOD1 was con- structed by transfection of the human neuroblastoma cell line SH-SY5Y with G93A-SOD1 ...
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The SH-SY5Y cell line in Parkinson’s disease research: a systematic review
... RA-differentiated SH-SY5Y cells as PD-model should be interpreted with ...differentiate SH- SY5Y cells is a sequential treatment with RA, usually 10 μM, and ...
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Original Article Puerarin attenuates cognitive dysfunction and oxidative stress in vascular dementia rats induced by chronic ischemia
... and cell death ...of SH-SY5Y cells under hydrogen peroxide ...of SH-SY5Y cells stimulated by hydrogen peroxide with or without treatments of dif- ferent dosages of ...positive ...
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On the cytotoxicity of HCR NTPase in the neuroblastoma cell line SH SY5Y
... Analysing the phylogenetic distribution of COG1618 pro- teins by phylogenetic COG ranking [11,12] reveals that they are absent from almost all mesophiles and present in all thermophiles, most of them archeae. In ...
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Original Article Overexpression of p58ipk protects neuroblastoma against paraquat-induced toxicity
... for cell apoptosis and Bax contribute to promote the cell ...the cell apoptosis ...the cell apop- tosis. These results suggested that PQ shift cell apoptosis, and low-expression of ...
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Promotion of SH SY5Y Cell Growth by Gold Nanoparticles Modified with 6 Mercaptopurine and a Neuron Penetrating Peptide
... As can be seen from the results, the particles pos- sessed an obvious acid-base property, which was related to the dissociation of the N(9)-H group of 6MP mol- ecule that took place in a pH range of 10.4 ~ 11.2 in so- ...
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Esomeprazole and pantoprazole enhance the antiproliferative effects of cisplatin on the human neuroblastoma SH-SY5Y cell line
... Background: Proton pump inhibitors (PPIs) largely used a drug to treat gastroesophageal disease such as gastric ulcers. Moreover, in recent years, several studies suggest that PPIs have an important anti-cancer effect in ...
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Original Article Isatin inhibits SH-SY5Y neuroblastoma cell invasion and metastasis through PTEN signaling
... Total RNA was extracted from the cultu- red SH-SY5Y cells with Trizol reagent (Solar- bio, Beijing, China). A reverse transcription kit (Transgene, Beijing, China) was used to con- struct the template cDNA ...
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<p>Tetramethylpyrazine attenuated bupivacaine-induced neurotoxicity in SH-SY5Y cells through regulating apoptosis, autophagy and oxidative damage</p>
... reverse BUP-induced oxidative damage in SH-SY5Y cells. However, when 3-MA was present, the level of total GS, SOD and MDA returned to the level of the BUP group. All these reports con fi rm our fi ndings that ...
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In vitro neuroprotective effect of charantin from Momordica charantia against neurotoxin and endoplasmic reticulum stress-induced cell death in SH-SY5Y cells
... study reveals that chrantin causes neuroprotection against MPP+ induced neuronal damage. Charantin when added at 8 h and 16 h after MPP+ treatment at a concentration of 1 mg/ ml showed a cell viability of 44% and ...
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Neuroprotective effects of melittin on hydrogen peroxide induced apoptotic cell death in neuroblastoma SH SY5Y cells
... is mediated by mitochondria through intrinsic pathways that activate caspases [22]. The Bcl-2 family contains two groups, an anti-apoptotic group (Bcl-2 and Bcl-x L) and a pro-apoptotic group (Bax, Bid and Bak), and ...
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Original Article Gastrodin improves cognitive dysfunction and decreases oxidative stress in vascular dementia rats induced by chronic ischemia
... lipids, cell proteins and nuclear acids within the nuclei that eventually lead to cellular ...vitro, SH-SY5Y cells were selected to be cultured in vitro and stimulated with hydrogen peroxide as ...
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