SH3 domain
Tau phosphorylation regulates the interaction between BIN1’s SH3 domain and Tau’s proline-rich domain
... Tau full-length (FL) 2N4R cDNA in pcDNA four was a kind gift from Luc Buée (INSERM U837, Lille, France). The BIN1 isoform used in the present study corresponds to the longest neuronal isoform 1 and will be denoted as ...
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The murine AIDS virus Gag precursor protein binds to the SH3 domain of c-Abl.
... docking molecule and binds to the c-Abl protein through its SH3 domain. This interaction appears to lead to the translo- cation of a fraction of c-Abl out of the nucleus, to the mem- brane, and to an ...
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Disruption of fyn SH3 domain interaction with a proline rich motif in liver kinase B1 results in activation of AMP activated protein kinase
... Fyn SH3 domain or the proline-rich motif of LKB1 resulted in the disruption of Fyn/LKB1 binding, re-localization of 70% of LKB1 signal in the cytoplasm and a 2-fold increase in AMPK ...
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Complex formation of EphB1/Nck/Caskin1 leads to tyrosine phosphorylation and structural changes of the Caskin1 SH3 domain
... the SH3 domain. By modeling the 3D structure of the rat Caskin1 SH3 domain it was found that Tyr296 is localized in the flexible RT loop linking the first two beta-strands, while Tyr336 is ...
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An update on the LIM and SH3 domain protein 1 (LASP1): a versatile structural, signaling, and biomarker protein
... LIM domain, which is composed of two sequential zinc-binding modules with a typical LIM motif, followed by tandem 35-residue nebulin-like repeats named R1 and R2, and by a C-terminal SRC homology region 3 ...
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MC159 of Molluscum Contagiosum Virus Suppresses Autophagy by Recruiting Cellular SH3BP4 via an SH3 Domain-Mediated Interaction
... the SH3 binding capacity and potential SH3 partner specificity of MC159, we expressed it in human 293T cells fused to a biotin acceptor domain (BD) and bound it to streptavidin-coated beads for ...
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SH3-domain binding protein 1 in the tumor microenvironment promotes hepatocellular carcinoma metastasis through WAVE2 pathway
... SH3-domain binding protein-1 (SH3BP1) specifically inactivating Rac1 and its target WAVE2 is required for cell motility. The present study shows SH3BP1 expression patterns in human HCC tissues and cell ...
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Alterations of sorbin and SH3 domain containing 3 (SORBS3) in human skeletal muscle following Roux-en-Y gastric bypass surgery
... of these marks has regulatory influence on gene expres- sion [7]. Our previously published study identified a novel gene, sorbin and SH3 domain containing 3 (SORBS3), that was differentially methylated with ...
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Hepatitis C virus NS5A protein binds the SH3 domain of the Fyn tyrosine kinase with high affinity: mutagenic analysis of residues within the SH3 domain that contribute to the interaction
... cell SH3 domains – the best characterised of these is the HIV- 1 Nef ...the SH3 domain of the Src-family kinase, Hck, is reported as one of the strongest interactions between an SH3 ...
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Hepatitis C virus NS5A protein binds the SH3 domain of the Fyn tyrosine kinase with high affinity: mutagenic analysis of residues within the SH3 domain that contribute to the interaction
... of domain I has been determined and it has been shown to complex with a zinc ion and (at least in the crystal structure) exists as a dimer ...the SH3 domains of the Src-family kinases Fyn, Lyn, Hck and Lck ...
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A Focal Adhesion Kinase-Derived Peptide Binds the Src SH3 Domain in Two Orientations, As Demonstrated Using Paramagnetic Nuclear Magnetic Resonance
... contrast with some low-a ffi nity protein complexes in which the partners are in a dynamic encounter state for a signi fi cant fraction of the time. This conclusion was based on the well- de fi ned CSP map and the localized ...
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Mutations in the SH3 domain of the src oncogene which decrease association of phosphatidylinositol 3'-kinase activity with pp60v-src and alter cellular morphology.
... 2 showed that immunoprecipitates of pp6ovs?' from cells infected with the CU12 src mutant, which had an extreme fusiform morphology, had reduced PI 3'-kinase activity, whereas the other [r] ...
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Mutations in the nebulin gene associated with autosomal recessive nemaline myopathy
... serine-rich domain with potential RS-phosphorylation motifs, and the SH3-domain of the ...the SH3 domain is shown below the exonyintron ...
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A lin-45 raf Enhancer Screen Identifies eor-1, eor-2 and Unusual Alleles of Ras Pathway Genes in Caenorhabditis elegans
... second SH3 domain of the sem-5/ Grb2 adaptor, a temperature-sensitive mutation in the helical hairpin of let-341/Sos, a gain-of-function mutation affecting a potential phosphorylation site of the lin-1 Ets ...
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Characterization of amphioxus nebulin and its similarity to human nebulin
... 185–SH3 domain and the SH3 domain bind to tropomodulin, desmin, connectin (also called titin), and myopalladin and β -actinin (also called CapZ), respectively (Bang et ...
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Chikungunya Virus nsP3 Blocks Stress Granule Assembly by Recruitment of G3BP into Cytoplasmic Foci
... variable domain inhib- ited the formation of foci and restored the ability of the host cell to form bona fide SGs, we set out to determine the element respon- sible within this ...(SH3) ...
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Overlapping effector interfaces define the multiple functions of the HIV 1 Nef polyproline helix
... for SH3 domain proteins have been suggested for several Nef activities: 1) the SH3 do- main protein, Hck, is known to bind Nef with nM affinity [20]; 2) Activation of Hck and other Src family kinases ...
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In vivo analysis of highly conserved Nef activities in HIV 1 replication and pathogenesis
... coding sequence (LAINefdd) in BLT humanzed mice [44]. LAI exhibited high levels of viral replication and near total depletion of CD4 + T cells in blood and tissues, as well as, depletion of CD4 + CD8 + thymocytes from ...
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The Adaptor Protein soc-1/Gab1 Modifies Growth Factor Receptor Output in Caenorhabditis elegans
... suggests that soc-1/Gab1 modulates daf-2A and daf-2B signaling distinctly. It is hypothesized that soc-1 nega- tively regulates daf-2A signaling and positively regulates daf-2B signaling. However, soc-1/Gab1 enhances the ...
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Heterologous SH3 p85β inhibits influenza A virus replication
... to SH3 domain of p85b and hence promote the activation of PI3K [14], whereas mutation within the SH3 binding motif 1 of NS1 is able to deprive NS1-p85b interaction and result in the reduction of ...
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