Shared epitope
Validation of the reshaped shared epitope HLA DRB1 classification in rheumatoid arthritis
... the shared epitope hypothesis in rheumatoid arthritis (RA); according to this model, RA is associated with the RAA shared epitope sequence (72–74 positions) and the association is modulated by ...
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Peptidyl arginine deiminase type IV (PADI4) haplotypes interact with shared epitope regardless of anti cyclic citrullinated peptide antibody or erosive joint status in rheumatoid arthritis: a case control study
... Rheumatoid arthritis (RA) is a chronic inflammatory dis- ease with a complex etiology that involves both genetic and environmental contributions; the pathogenesis of RA is still not fully understood. The genetic ...
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T cell autoreactivity to citrullinated autoantigenic peptides in rheumatoid arthritis patients carrying HLA DRB1 shared epitope alleles
... to shared epitope HLA-DR alleles [7] (and unpublished data), RA patients produced significantly greater amounts of IL-6, TNF and IL-10 in response to citrulli- nated than native aggrecan peptides (Figures ...
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The rheumatoid arthritis shared epitope increases cellular susceptibility to oxidative stress by antagonizing an adenosine mediated anti oxidative pathway
... We have recently demonstrated that the rheumatoid arthritis (RA) shared epitope (SE) acts as a ligand that triggers nitric oxide (NO) signaling in opposite cells. Given the known pro- oxidative effect of NO ...
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Associations of antibodies against citrullinated peptides with human leukocyte antigen shared epitope and smoking prior to the development of rheumatoid arthritis
... antigen-shared epitope (HLA-SE) alleles and smoking on the development of ACPA, as well as in combination with ACPA during the state of quiescent autoimmunity (before the onset of symptoms), on the ...
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Anti citrullinated peptide autoantibodies, human leukocyte antigen shared epitope and risk of future rheumatoid arthritis: a nested case–control study
... the shared epitope had higher affinity for citrullinated pep- tides in mice and that citrullinated peptide modification activated a CD4+ T-cell response ...
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Hypogalactosylation of immunoglobulin G in rheumatoid arthritis: relationship to HLA DRB1 shared epitope, anticitrullinated protein antibodies, rheumatoid factor, and correlation with inflammatory activity
... Background: Galactosylation of immunoglobulin G (IgG) is reduced in rheumatoid arthritis (RA) and assumed to correlate with inflammation and altered humoral immunity. IgG hypogalactosylation also increases with age. To ...
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B lymphocytopenia in rheumatoid arthritis is associated with the DRB1 shared epitope and increased acute phase response
... so-called shared epitope on a DRB1*04 allele, were found to suffer from a more rapid and severe course of joint ...the shared epitope seems sufficient to transmit a significantly increased ...
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HLA DRB1 shared epitope genotyping using the revised classification and its association with circulating autoantibodies, acute phase reactants, cytokines and clinical indices of disease activity in a cohort of South African rheumatoid arthritis patients
... revised shared epitope (SE) concept in rheumatoid arthritis (RA) is based on the presence (S) or absence (X) of the SE RAA amino acid motif at positions 72 to 74 of the third hypervariable region of the ...
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Spontaneous destructive periodontitis and skeletal bone damage in transgenic mice carrying a human shared epitope coding HLA DRB1 allele
... Figure 1 Periodontal micro-CT analyses. (A) 3D micro-CT-based quantification of mandibular bone parameters in SE-positive DRB1*04:01 (black bars) and SE-negative DRB1*04:02 (gray bars) Tg mice. Values represent mean and ...
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Diagnostic value of anti cyclic citrullinated peptides and association with HLA DRB1 shared epitope alleles in African rheumatoid arthritis patients
... 24. Hughes LB, Morrison D, Kelley JM, Padilla MA, Vaughan LK, Westfall AO, Dwivedi H, Mikuls TR, Holers VM, Parrish LA, Alarcón GS, Conn DL, Jonas BL, Callahan LF, Smith EA, Gilkeson GS, Howard G, Moreland LW, Patterson ...
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Cells of the synovium in rheumatoid arthritis T lymphocytes
... Cell-cell contact is necessary both at the inductive phase of T- cell activation in RA and at the effector phase, in which T cells indirectly mediate autoantibody production, joint inflammation, and bone resorption [33]. ...
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Influence of HLA DRB1 alleles in the susceptibility of rheumatoid arthritis and the regulation of antibodies against citrullinated proteins and rheumatoid factor
... Figure 1 Box plots of anti-citrullinated protein antibody (ACPA) levels (a) and rheumatoid factor (b) in rheumatoid arthritis pa- tients depending on the number of shared epitope (SE) alleles. ACPA levels ...
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Identification of a Shared Cytochrome p4502E1 Epitope Found in Anesthetic Drug-Induced and Viral Hepatitis
... one shared epitope between anesthetic and viral hepatitis that may contribute to sequelae following exposure to drugs or viruses and strongly suggests that this epitope could be the dominant CYP2E1 ...
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The role of the T cell in autoimmune inflammation
... Association of rheumatoid arthritis with HLA-DR4 and HLA-DR1 subtypes shared epitope Enrichment of activated CD4+ memory T cells in peripheral blood, synovial membrane, and synovial flui[r] ...
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Distinct Evolutionary Pressures Underlie Diversity in Simian Immunodeficiency Virus and Human Immunodeficiency Virus Lineages
... different epitope loci recognized and depth referring to the recognition of multiple vari- ants at individual epitope ...potential epitope coverage above a given ...cine-induced epitope ...
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A Novel CD8-Independent High-Avidity Cytotoxic T-Lymphocyte Response Directed against an Epitope in the Phosphoprotein of the Paramyxovirus Simian Virus 5
... Recombinant viruses. Plasmids carrying the SV5 NP (33), P and V (46), M (41), F (35), SH (22), HN (21), and L (33) genes have been described. Vaccinia viruses expressing the HN and F proteins were kindly provided by R. ...
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Relative Dominance of Epitope-Specific Cytotoxic T-Lymphocyte Responses in Human Immunodeficiency Virus Type 1-Infected Persons with Shared HLA Alleles
... each epitope and which epitopes were targeted as the dominant ...A2-restricted epitope p17 ...this epitope is not representative of the total HIV-1-specific CTL ...77–85 epitope among the ...
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Proteomic Analysis and Immunogenicity of Mannheimia haemolytica Vesicles
... immunodominant epitope of PlpE and the neutralizing epitope of LKT (11) stimulated antibodies with po- tent complement-mediated cell killing and LKT-neutralizing ac- tivities, whereas cattle vaccinated with ...
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IN SILICO EPITOPE PREDICTION AND HOMOLOGY MODELING OF ENVELOPE SURFACE GLYCOPROTEIN GP160, PRECURSOR REGION FROM HUMAN IMMUNO DEFICIENCY VIRUS 1
... To optimize the activity of the predicted epitopes; these epitopes were docked against the selected antibodies. For each docking, the lowest energy docked structure was selected from their respective runs which were ...
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