Shh signalling
Autonomous and non autonomous Shh signalling mediate the in vivo growth and guidance of mouse retinal ganglion cell axons
... derived Shh mostly affects C-RGC axons, we cannot exclude the possibility that the difference observed in vitro between I- and C-RGC axons might reflect an effect that Shh secreted by C-RGCs may exert on ...
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Protease nexin 1 and its receptor LRP modulate SHH signalling during cerebellar development
... the SHH transcriptional targets Gli1 and Ptc1 in the oEGL, indicative of enhanced SHH signal ...the SHH- mediated, controlled local increase in the proliferation of CGNPs determines the extent of ...
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Ftm is a novel basal body protein of cilia involved in Shh signalling
... of Shh signalling, we analysed patterning of the neural tube, a structure allowing precise measurement of effects on Shh ...signalling. Shh is expressed in two ventral signalling ...
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Wnt canonical pathway restricts graded Shh/Gli patterning activity through the regulation of Gli3 expression
... of Shh, Ptch1 acts to suppress the activity of a second transmembrane protein, smoothened (Smo) (for reviews, see Ingham and McMahon, 2001; Lum and Beachy, ...by Shh relieves repression of Smo, then, ...
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Differential regulation of gene expression in the digit forming area of the mouse limb bud by SHH and gremlin 1/FGF mediated epithelial mesenchymal signalling
... ZPA-SHH signalling centres and differential mesenchymal responsiveness are established under the influence of the GLI3R-HAND2 pre-patterning mechanism ...to SHH signalling is probably set- up ...
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Temporal progression of hypothalamic patterning by a dual action of BMP
... (BMP) signalling ligands play key roles in regulating cell identities in the neural tube (Ericson et ...and Shh, which emanate from dorsal and ventral regions, respectively, establish opposing spatial ...
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Early mouse caudal development relies on crosstalk between retinoic acid, Shh and Fgf signalling pathways
... requires Shh signalling in order not to be processed into a negative form (Litingtung et ...of Shh signalling in neural and mesodermal tissues, but could also have independent ...and ...
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Ventral midline neuroectoderm development along the anteroposterior axis of the vertebrate embryo
... of SHH signal, a second possibility for the differential p attern in g activities of prechordal m esoderm and notochord m ay be th at prechordal m esoderm expresses a molecule(s) that alters the signalling ...
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Sonic hedgehog dependent synthesis of laminin α1 controls basement membrane assembly in the myotome
... of Shh in the pre- somitic ...of Shh signalling (purple arrow) in the paraxial mesoderm at the time somites form and assembles with β1 and γ1 laminin chains into a laminin-111 network in the ...Under ...
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SHH propagates distal limb bud development by enhancing CYP26B1 mediated retinoic acid clearance via AER FGF signalling
... (SHH) signalling by the limb bud organizer located in the posterior mesenchyme mainly controls establishment of the anteroposterior (AP) limb bud axis, which manifests predominantly in digit identities of ...
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FGF signalling generates ventral telencephalic cells independently of SHH
... of Shh to generate ventral cell types (Fig. 8). First, although SHH is required to induce ventral telencephalic cell types (Ericson et ...both SHH and GLI3 are lost, indicating that another factor ...
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Primary cilia regulate Shh activity in the control of molar tooth number
... Although Shh is only expressed in the epithelium during tooth development, Ptch1 and other Shh pathway molecules are expressed in both epithelial and mesenchymal cells in early tooth ...for Shh in ...
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Temporal and spatial requirements of Smoothened in ventral midbrain neuronal development
... [23]), anti-β-galactosidase (β-Gal; 1:20; #40-1a; Develop- mental Hybridoma Study Bank (DHSB), Iowa City, IA, USA), anti-Foxa2 (1:500; #3143; Cell Signaling Technology, Danvers, MA, USA), anti-5-hydroxytryptamine ...
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The transition from differentiation to growth during dermomyotome derived myogenesis depends on temporally restricted hedgehog signaling
... excess Shh. (G) Embryos co-transfected with Shh and Hhip to ...of Shh to ectoderm (arrows) followed by Hhip to ...of Shh alone to ectoderm ...local Shh application ...
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Pancreatic stellate cells contribute pancreatic cancer pain via activation of sHH signaling pathway
... We have previously shown the role of PSCs and the sHH pathway in our in vitro co-culture system. Although some studies have found that TRPV1 is essential for pain in pancreatic disease [7, 40], we investigated the ...
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<p>Curcumin Affects Gastric Cancer Cell Migration, Invasion and Cytoskeletal Remodeling Through Gli1-β-Catenin</p>
... through Shh signaling, 39 which was consistent with our results that curcumin inhibited the migration of SGC-7901 cells through Shh signaling ...through Shh and Wnt signaling ...
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A dynamic Shh expression pattern, regulated by SHH and BMP signaling, coordinates fusion of primordia in the amniote face
... of Shh in the ectoderm covering the frontonasal (FNP) and maxillary (MxP) ...this Shh expression domain contributes to the morphogenetic processes that drive the directional growth of the globular process ...
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Notochord derived Shh concentrates in close association with the apically positioned basal body in neural target cells and forms a dynamic gradient during neural patterning
... of Shh::GFP puncta associated with the lysosome, an organelle expected to degrade internalized Shh ligand ...of Shh::GFP ligand puncta with the basal body, we quantified the basal body association ...
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NF κB transmits Eda A1/EdaR signalling to activate Shh and cyclin D1 expression, and controls post initiation hair placode down growth
... U36277/NM010907), Shh (nt 120-760, X76290), cyclin D1 (nt 931-2358, BC044841), Eda A1 (tabby) (nt 2309-2945, Y13438) and TROY (nt 135- 591, AB040432) (Ohazama et ...
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Sonic hedgehog, secreted by amacrine cells, acts as a short range signal to direct differentiation and lamination in the zebrafish retina
... of shh in the zebrafish ...of shh RNA in the retina at 46 ...of shh- GFP (green) and Zn5 (red). Note that shh-GFP and Zn5 are co-expressed in ganglion cells, and that shh- GFP is also ...
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