Shock proteins and disease
Are heat shock proteins therapeutic target for Parkinson's disease?
... Are heat shock proteins therapeutic target for Parkinson’s disease? Guang-Rui Luo 1 , Sheng Chen 2 , Wei-Dong Le 1 1. Institute of Health Sciences, Shanghai Institutes of Biological Sciences, Chinese ...
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Cold shock proteins: from cellular mechanisms to pathophysiology and disease
... cold shock proteins within exosomes and thus their extracellular activities and we have a long road ahead to fully understand the complex behavior and activities of these fascinating proteins in both ...
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Heat shock proteins in health and disease: therapeutic targets or therapeutic agents?
... heat shock protein biology that remain ...heat shock proteins appears to be associated with several pathological disease states, yet, on the other hand, heat shock proteins are ...
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Heat shock proteins expressed in the marsupial Tasmanian devil are potential antigenic candidates in a vaccine against devil facial tumour disease
... heat shock proteins (HSPs) derived from tumour cells have been used instead of whole-tumour cell preparations as a source of anti- gens for cancer ...these proteins as antigenic components for the ...
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Small heat shock proteins and apolipoprotein E in Alzheimer's disease.
... Aβ-associated proteins, that may affect the biological function of Aβ (119), amongst which are the small heat shock proteins ...of proteins functioning as molecular chaperones that can prevent ...
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Extracellular cell stress (heat shock) proteins - immune responses and disease: an overview
... new proteins, yet found it surprisingly difficult to publish this ...heat shock. It was also noted that cellular levels of some proteins that were present before the application of elevated ...
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The two-faced nature of small heat shock proteins: amyloid assembly and the inhibition of fibril formation. Relevance to disease states
... target proteins to prevent their aggregation ...these proteins since they are likely to discourage formation of inter-molecular contacts that could lead to fibril formation ...
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Implications of heat shock / stress proteins for medicine and disease
... heat shock response, first observed in Drosophila melanogaster over thirty years ago (1), is now recognized to represent a universally conserved cellular defense ...heat shock response is mediated by the ...
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Heat-shock proteins in neuroinflammation
... the disease in response to seizures, suggesting that plasma HSPD1 can be used as a biomarker reflecting neuronal cell death ( Gammazza et ...the disease ( Nakhjavani et ...
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Heat shock proteins in multiple myeloma
... heat shock protein ...heat shock elements in the promoter regions of target proteins [100, ...heat shock protein expression with its downstream targets such as Hsp72 and ...heat shock, ...
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Heat Shock Proteins in Histoplasma and Paracoccidioides
... significant disease in both immunocompetent and compromised humans, with severe disease occurring more frequently in individ- uals with cellular ...Heat shock proteins (Hsps) are ubiquitous ...
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Involvement of heat shock proteins in gluten-sensitive enteropathy
... coeliac disease (CD) is a gluten-free ...heat shock proteins (HSPs) for the treatment of various autoimmune disorders and cancers have been developed and have shown promis- ing ...
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Detection of autoantibodies against heat shock proteins and collapsin response mediator proteins in autoimmune retinopathy
... heat shock protein 60 (hsp60) and collapsin response mediator protein 2 (CRMP2) as possible autoantigens frequently observed in patients with CAR, MAR and ...
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Stress proteins in Alzheimer's disease
... cause proteins to misfold or to accumulate abnormally due to impaired ...heat shock proteins, aid survival by preventing protein mis-folding and the formation of cytotoxic protein ...Heat ...
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A dynamics based analysis of allosteric modulation in heat shock proteins
... heat shock proteins (Hsp70 and Hsp90) are molecular chaperones that play central roles in maintaining cellular homeostasis in all organisms of life with the exception of ...multi-domain proteins that ...
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Heat shock proteins and hormesis in the diagnosis and treatment of neurodegenerative diseases
... chronic disease involves the optimized challenging of cells and whole organisms by any of a wide range of stressors including pharmacological, physical, diet- ary, exercise, and ...
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The Gordian knot of small heat shock proteins and tissue transglutaminae
... aggregated proteins in the form of inclusions and amyloid-like deposits are called inclusion body ...Huntington’s disease and cerebellar ataxias, the damaged tissues often display elevated tissue ...
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Cytokines and the regulation of heat shock proteins in systemic lupus erythematosus
... elevated levels of IL-6 and not elevated levels of IL-10, in patients with this disease. Of particular interest to the studies in this chapter, is the observation of an increased correlation between levels of IL-6 ...
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Small heat shock proteins: Role in cellular functions and pathology
... identical disease conditions, indicating that the sHsps, in addition to their similar functions, also have distinct ...causes disease could be differ- ent, but converge into the pathways that are critical ...
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Newcastle disease virus stimulates the cellular accumulation of stress (heat shock) mRNAs and proteins.
... kilodalton stress proteins synthesized in reticu- locyte lysates in response to mRNAs extracted from AV-infected cells (Fig. 4, lane A) and Bi- infected cells (lane C) were approximately[r] ...
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