Sickle Cell Trait
Biochemical and immunological mechanisms by which sickle cell trait protects against malaria
... (PfEMP-1) molecules on the erythrocyte surface, and via this protein adhere to endothelial cells in the microvascu- lature [61-64] .This process, termed cytoadherence, en- ables parasites to sequester in the vasculature ...
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Storage related haematological and biochemical changes in Plasmodium falciparum infected and sickle cell trait donor blood
... Sickle cell haemoglobin result when valine substitutes for glutamic acid at position 6 of the β-globin ...a sickle cell trait (SCT) or is said to be a carrier of sickle ...
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Hemoglobin K Woolwich (Hb KW): Its Combination with Sickle Cell Trait
... benign trait, whereas others indicate it may behave si- milarly to a β + ...with sickle cell trait and a delay of hemoglobin F to adult ...
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Relationships between sickle cell trait, malaria, and educational outcomes in Tanzania
... There is a large literature suggesting that malaria explains an important component of the lagging devel- opment performance of sub-Saharan Africa [6]. Using micro data, several recent papers [7–12] show long run ...
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Diabetes at Sickle Cell Trait with the Treatment of Medicinal Plants: A Study
... the sickle cell trait may protect against malaria, inheritance of two abnormal genes leading to SCD offers no such protection, and malaria is a major cause of ill-health and death in people with SCD ...
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Increased Complement Deposition on Red Blood Cells in Children with Sickle Cell Trait
... In sickle cell trait individuals, the levels of these complement regulatory proteins were however comparable in the younger age groups but beyond the age of 49 months and this was thought to be a ...
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Evaluation of the implantation of the national neonatal screening program regarding coverage index, disease prevalence and sickle cell trait in mato grosso do sul Brazil: 2001 – 2015
... of sickle cell anemia" (CAMPO GRANDE, ...Deficiency, Sickle cell Diseases and other hemoglobinopathies (MATO GROSSO, ...with sickle cell trait (HbAS) in Brazil, with ...
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Immunological Characterization in Malaria Patients with and without the Sickle Cell Trait
... As an alternative explanation, it seems possible that by controlling parasite densities during malaria infections [46] innate processes might paradoxically increase the chronicity of individual infections. This ...
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An up-date on the prevalence of sickle cell trait in Eastern and Western Uganda
... Sickle cell disease is an inherited hemoglobinopathy aris- ing from the substitution of glutamic amino acid by valine in the sixth position of the beta globin chain ...the sickle cell ...
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FAMILIAL DIFFERENCES IN THE PROPORTION OF ABNORMAL HEMOGLOBIN PRESENT IN THE SICKLE CELL TRAIT
... For each family it is known that only one parent exhibited the sickle cell trait, the other parent being normal in this respect This was an essential prerequisite to a study of this natu[r] ...
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Sickle Cell Trait and Sudden Death
... When sickle hemoglobin is deoxygenated, the mole- cules have an increased tendency to form hydrophobic bonds and will subsequently aggregate into large poly- mers on the red blood cell ...the cell. ...
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Effectiveness of Hydroxyurea Therapy in Sickle Cell Disease and Sickle Cell Trait
... of sickle cell disease (SS) and trait (AS), fulfilling all eligibility criteria, attending general medicine, sickle cell OPD and medicine wards were included after obtaining written ...
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PATHOGENESIS OF HYPOSTHENURIA IN PERSONS WITH SICKLE CELL ANEMIA OR THE SICKLE CELL TRAIT
... over 6 months of age have hyposthenunia; 2) hyposthenuria becomes increasingly more severe with advancing age in both sickle cell anemia and sickle cell trait; 3) in a 6-month-old patien[r] ...
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Renal Medullary Carcinoma in an Adolescent With Sickle Cell Trait
... with sickle cell ...loss. Sickle cell trait as the sole cause of hematuria in young black patients is a diagnosis of ...http://www.pediatrics.org/cgi/content/full/103/2/e22; ...
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Sickle Cell Trait Screening in Athletes: Pediatricians' Attitudes and Concerns
... The methods preferred for obtaining an athlete’s sickle cell status were var- ied. The majority of pediatricians pre- fer identification based on the pa- tient’s medical record (71%), although 21% thought ...
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Effects of alpha thalassemia and sickle polymerization tendency on the urine concentrating defect of individuals with sickle cell trait
... These observations are consistent with the hypothesis that the tendency for intracellular sickle hemoglobin polymerization found in the erythrocytes present in the vasa recta of the rena[r] ...
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ANESTHETIC RISKS IN SICKLE CELL TRAIT
... Most clinical disease associated with sick- ling of red blood cells has been described in sickle cell anemia ( S-S hemoglobinopathy),. sickle cell-hemoglobin C disease ( S-C hemo-[r] ...
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Imbalanced Distribution of Plasmodium falciparum MSP-1 Genotypes Related to Sickle-Cell Trait
... falciparum genotypes suggests that parasite fitness for a specific host is strain-dependent, which is consistent with our hypothesis that innate resistance might result from reduced fitn[r] ...
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OXYGEN DISSOCIATION CURVES IN SICKLE CELL ANEMIA AND IN SUBJECTS WITH THE SICKLE CELL TRAIT
... Table I indicates that despite efforts to keep the pCO2 constant in all studies, the mean pCO2 for the experimental points calculated in the cases of sickle cell anemia was higher than t[r] ...
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To test or not: occurrence of sickle cell trait and assessment of the awareness toward its screening among patients attending Magale Health Center IV, Namisindwa District, Eastern Uganda
... indicated nor done, the career likelihood is rather amplified and may promulgate the genotypes and the associated defects. Our study ought to be interpreted in light of these limitations. First, the rapid sickle ...
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