signal transducer
Signal transducer and activator of transcription 1 localizes to the mitochondria and modulates mitophagy
... The signal transducer and activator of transcription (STAT) proteins are latent transcription factors that have been shown to be involved in cell proliferation, development, apoptosis, and ...
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Signal Transducer and Activator of Transcription 3 in Liver Diseases: A Novel Therapeutic Target
... common signal transducer of IL-6 family cytokines) in hepatocytes had no effect on liver fibrosis, while deletion of gp130 in nonpa- renchymal liver cells aggravated fibrosis progression ...
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Polymorphisms in signal transducer and activator of transcription 3 and lung function in asthma
... Signal transducer and activator of transcription 3 (STAT3) is a member of a protein family of transcription factors, which was discovered in the course of studies of inter- feron-induced intracellular ...
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Silica Nanoparticles Target a Wnt Signal Transducer for Degradation and Impair Embryonic Development in Zebrafish
... Wnt signaling controls a variety of physiological processes including embryonic axis elongation and segmentation, organ development, tissue homeostasis and stem cell maintenance[14, 15]. In addition, dysregulation of Wnt ...
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<p>The Hedgehog signal transducer <em>Smoothened</em> and microRNA-326: pathogenesis and regulation of drug resistance in pediatric B-cell acute lymphoblastic leukemia</p>
... a signal transducer, which eventually results in the activation and nuclear translocation of Gli transcription factors (Gli 1, Gli 2, and Gli 3) at target ...key signal transducer involved in ...
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Expression of activated signal transducer and activator of transcription 3 as a predictive and prognostic marker in advanced esophageal squamous cell carcinoma
... cancer is an aggressive upper gastrointestinal malignancy which generally presents as a locally advanced tumor that requires multimodal therapy, and the prognosis in patients with esophageal cancer remains poor, with a ...
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<p>Luteolin Attenuates Atherosclerosis Via Modulating Signal Transducer And Activator Of Transcription 3-Mediated Inflammatory Response</p>
... Method: ApoE -/- mice were fed with a high-fat diet to induce atherosclerosis in an animal model, where they were treated with oral administration of luteolin for 12 weeks. Primary mouse peritoneal macrophages challenged ...
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Identification of Drosophila Genes Modulating Janus Kinase/Signal Transducer and Activator of Transcription Signal Transduction
... The canonical pathway in Drosophila consists of the homologous secreted ligands Unpaired (Upd), Upd2, and Upd3 (H arrison et al. 1998; A gaisse et al. 2003; H ombria et al. 2005) and a cytokine-like transmembrane ...
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Signal Transducer and Activator of Transcription 4 in Liver Diseases
... STAT4 is a member of the signal transducer and activator of transcription (STAT) family of molecules that localizes to the cytoplasm. STAT4 regulates various genes expression as a tran- scription factor ...
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Constitutive activation of an epithelial signal transducer and activator of transcription (STAT) pathway in asthma
... cytokine signal transduc- tion (as opposed to altered cytokine production) in the pathogenesis of an inflammatory ...cytokine signal trans- duction that leads to Stat1 activation and enhanced expression of ...
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Modulating Antiangiogenic Resistance by Inhibiting the Signal Transducer and Activator of Transcription 3 Pathway in Glioblastoma
... Patients with recurrent GB who were treated with bevacizumab had a mean of 36.7 + 7.4% p-STAT3 expressing cells in comparison to a recurrent glioblastoma cohort that had never received a[r] ...
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Paeoniflorin inhibits human glioma cells via STAT3 degradation by the ubiquitin–proteasome pathway
... Abstract: We investigated the underlying mechanism for the potent proapoptotic effect of paeoniflorin (PF) on human glioma cells in vitro, focusing on signal transducer and activator of transcription 3 ...
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Original Article Inhibition of curcumin on proliferation and invasion in giant cell tumor of bone (GCTB) by targeting STAT3
... the signal transducer and activator transcription factor-3 (STAT3), as the main pro- tein in Jak-STAT3 signal pathway, has not been suggested as the direct target of curcumin, even in ...
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Gene Prioritization Through Consensus Strategy, Enrichment Methodologies Analysis and Networking for Osteosarcoma Pathogenesis
... principal signal transducer that mediates processes associated with cell cycle, DNA damage response, DNA replication and intrinsic/extrinsic apoptotic signaling ...
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Tyrosine 625 plays a key role and cooperates with tyrosine 630 in MPL W515L-induced signaling and myeloproliferative neoplasms
... STAT5: signal transducer and activator of transcription 5; STAT3: signal transducer and activator of transcription 3; MAPK: mitogen-activated protein kinases; ERK: extracellular ...
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STAT4 Is Required for Antibacterial Defense but Enhances Mortality during Polymicrobial Sepsis
... The signal transducer and activator of transcription factor 4 (STAT4) pathway mediates the intracellular effects of interleukin-12 (IL-12), leading to the production of gamma interferon, induction of a T ...
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Genetic Variability and Significance of STAT Gene in Dairy Animals
... Signal transducer and activator of transcription (STAT) factors are a family of cytoplasmic proteins that are stimulated activated in response to a large number of cytokines, growth factors, and hormones in ...
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Potential use of STAT3 inhibitors in targeted prostate cancer therapy: future prospects
... 1 Signal transducer and activator of transcription 3 (STAT3) activation: STAT3 activation is initiated by binding of the ligand, interleukin 6 (iL-6), to its receptor, which consists of glycoprotein 80 kDA ...
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A ROLE OF MACROPHAGES: AN OVERVIEW
... Many key transcription factors are involved in macrophage polarization , like signal transducer and activator of transcription (STATs), interferon-regulatory factor (IRFs), nuc[r] ...
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A Rare Case of Hyper IgE Syndrome with Vocal Cords Involvement
... (Signal transducer and activator of transcription 3) however, mutations or deletions in genes DOCK8 (dedicator of cytokinesis 8) and TYK2 (tyrosine kinase 2) have been reported to be in the autosomal ...
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