signal transduction
Signal transduction, receptors, mediators and genes: younger than ever - the 13th meeting of the Signal Transduction Society focused on aging and immunology
... the Signal Transduction Society started with a workshop on Immune Signaling that was co-organized by the study group ‘Signal Transduction” of the German Society for Immunology and The ...
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Role of protein kinases in signal transduction and their inhibitors
... (i.e. signal transduction) and effectors in cellular functions, such as cell proliferation and ...to signal transduction, effects of overexpression of it and medicinal roles of diverse protein ...
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Eosinophils downregulate lung alloimmunity by decreasing TCR signal transduction
... Unlike other solid organ allografts, lungs are unique, as they are continuously exposed to the external envi- ronment as part of their natural function of gas exchange. For these reasons, unique pulmonary-specific ...
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Signal Transduction Therapies for Treatment of Chronic Leukemias
... first signal transduction inhibitor; a class of small molecules referred as tyrosine kinase inhibitor (TKI): Imatinib Mesylate (Glivec or Gleevec, ...
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Signal transduction inhibitors in treatment of myelodysplastic syndromes
... therapeutically targeted by small molecule inhibitor of the TGF- β receptor kinase, LY-2157299, with encouraging preclinical results. Apart from TGF- β receptor kinase inhibition, members of TGF- β super family and BMP ...
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2R and remodeling of vertebrate signal transduction engine
... that signal transduction was the most enriched GO term (in stark contrast to tan- dem or segmental duplications, where this term was ...membrane-attached signal-processing com- plexes at ...
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Mitogen Activated Protein kinase signal transduction pathways in the prostate
... comprehensive review of studies specifically using pros- tate tissue or cell lines. Admittedly, many more publica- tions may have examined some aspect of MAPKs, but we focused on abstracts including MAPK, ERK, JNK, or ...
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Mechanism and evolution of cytosolic Hedgehog signal transduction
... Genes containing a Fu kinase domain are easily identifiable in all branches of the eukarya, with the exception of fungi (our unpublished results). This includes plants and single-celled eukaryotes such as Chlamydomonas ...
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Regulatory control of signal transduction during morphogenesis in Drosophila
... ABSTRACT Morphogenesis shapes pattern and size during development. The initiation and propagation of morphogenetic processes is led by the integrated activation of signaling cascades. Much is known about regulatory ...
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Protein dynamics and conformational selection in bidirectional signal transduction
... Three theories have been proposed to explain protein ligand interactions in signal transduction. The first, the ‘lock and key’ mechanism, considered the protein a rigid molecule that requires an exact ...
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Protein phosphorylation and its role in archaeal signal transduction
... Intriguingly, related to information processing, the processes involved in transformation of DNA to protein (e.g. replication, transcription, translation, repair) in Archaea resemble their re- spective eukaryotic ...
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Approximations and their consequences for dynamic modelling of signal transduction pathways
... Signal transduction is the process by which the cell converts one kind of signal or stimulus into another. This involves a sequence of biochemical reactions, carried out by proteins. The dynamic ...
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Probabilistic Prediction of Unknown Metabolic and Signal-Transduction Networks
... training data; however, the most strongly predicted inter- action was of Apaf-1 interacting with itself. A search of the signal-transduction literature revealed that Apaf-1 does, in fact, self-associate (Hu ...
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MDA5 and LGP2: Accomplices and Antagonists of Antiviral Signal Transduction
... synergistic signal transduction activity resulting from coexpression of LGP2 with MDA5 that was not attributable to either RLR alone (64), suggesting that LGP2 may synergize with MDA5 to promote effi- cient ...
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The involvement of Rho GTPases in plexin mediated signal transduction
... Semaphoring have been associated with the invasive and metastatic progression of many tumours (Trusolino and Comoglio, 2002). In non-small-cell lung carcinomas lower Sema3F expression levels correlate with higher stage ...
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Signal transduction in cells of the immune system in microgravity
... They found a reduction of phagocytosis and a reduced oxi- dative burst- and degranulation-capacity. Meloni et al. [29] recently demonstrated that simulated weightlessness leads to massive alterations in the cytoskeleton ...
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Signal transduction mechanisms of cryptochrome
... Cryptochromes are photoreceptors that mediate a wide variety of growth and adaptive responses in diverse organisms. Although a detailed photocycle has yet to be described for any cryptochrome, it is known that C-terminal ...
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THE ROLE OF Ca2+ IN SIGNAL TRANSDUCTION FOLLOWING FERTILIZATION IN FUCUS SERRATUS
... the signal-transduction mechanisms associated with activation of various animal ...in signal transduction during egg activation and to zygote ...
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Reactive oxygen species in signal transduction
... Often ROS-dependent signaling involves MAPKs (mitogen-activated protein kinases) and/ or PI3K (phosphatidylinositol-3-kinases)/Akt. In addition, the activity of other protein kinases, in- cluding protein kinase C (PKC), ...
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Signal transduction by the Fat cytoplasmic domain
... for signal transduction downstream of Fat by creating targeted alterations within a genomic construct that contains the entire fat locus, and by monitoring and manipulating the membrane localization of the ...
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