Signaling cascade
The p38 mitogen activated protein kinase signaling cascade in CD4 T cells
... In contrast to Th1-mediated autoimmune disorders, allergic disorders are mediated by Th2 cells through the production of IL-4, IL-5, and IL-13. Because of its central role in Th2 effector functions (Fig. 2), it is ...
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MicroRNA analysis suggests an additional level of feedback regulation in the NF-κB signaling cascade
... multiple signaling pathways, including those initiated by TNFα, various xenobiotics and stress factors ...RIPK1-dependent signaling leads to inflammation, necroptosis or apoptosis ...
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Activation of the PKR/eIF2α signaling cascade inhibits replication of Newcastle disease virus
... In the current report, we first demonstrated that the activities of phosphorylated PKR and eIF2α were grad- ually increased during NDV infection in both a time- and dose-dependent manner (Figure 1A–D). The fact that both ...
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Induction of the Gαq Signaling Cascade by the Human Immunodeficiency Virus Envelope Is Required for Virus Entry
... a signaling cascade in- volving G ␣ q , PLC, PKC, intracellular Ca 2⫹ release, Pyk2, and Ras that allows activation of Rac-1 and subsequent actin cy- toskeleton rearrangements necessary for ...host ...
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Deciphering the molecular signaling cascade in neuronal death
... 43 The key executioners that re-localize from the IMS to the cytosol (reviewed in Hengartner, 2000; Kroemer et al., 2007) include cytochrome c (CYTC), antagonists of inhibitor of apoptosis (IAP), ―second ...
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SH2B1 promotes NSCLC cell proliferation through PI3K/Akt/mTOR signaling cascade
... SH2B1 on Akt/mTOR/PTEN pathway. As expected, SH2B1 shRNA significantly decreased Akt (ser 473) and mTOR (ser 2448) phosphorylation in NSCLC A549 cells; however, no detectable changes in total Akt and mTOR protein were ...
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Insilico investigation of TNFSF10 signaling cascade in ovarian serous cystadenocarcinoma
... basic signaling pathways which are intrinsic and extrinsic ...apoptotic signaling [21- ...mediated signaling cascade in meningitis, in lammation, diabetes, asthma, immune diseases and ...
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Steroids initiate a signaling cascade that triggers rapid sporulation in Dictyostelium
... signaling cascade results in a million-fold amplification of the original ...multistep cascade regulating encapsulation are that most cells are required to produce SDF-3 such that it can accumulate ...
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Intracellular lactate signaling cascade in atrial remodeling of mitral valvular patients with atrial fibrillation
... lactate signaling cascade changes represent a cause- effect relationship or solely an association remains ...lactate signaling cascade may not only be a marker but also a mediator in the ...
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The Polyketide MPBD Initiates the SDF-1 Signaling Cascade That Coordinates Terminal Differentiation in Dictyostelium
... transduction cascade through the membrane receptor CrlA coupled to G ␣ 1, leading to the inhibition of GskA so that the precursor of SDF-1 is ...This signaling cascade shows similarities to the SDF-2 ...
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CK2-NCoR signaling cascade promotes prostate tumorigenesis
... To further explore the clinical relevance of CK2- NCoR signaling and prostate cancer development, NCoR phosphorylation and IP-10 expression were evaluated by immunohistochemistry using tissue microarrays. Sixty ...
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An Nfic hedgehog signaling cascade regulates tooth root development
... genes related to the Hh signaling pathway, including ligands, receptors, transcriptional effectors, regulators and other mediators. The Hh negative regulator Hhip was significantly reduced in Nfic −/− mice ( P ...
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3,4-dihydroxyphenyl acetic acid and (+)-epoxydon isolated from marine algae-derived microorganisms induce down regulation of epidermal growth factor activated mitogenic signaling cascade in Hela cells
... (Erk1/2) signaling pathway can be activated in re- sponse to a diverse range of extracellular stimuli including mitogens, growth factors, and cytokines [27,28] and is an important target in the diagnosis and ...
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<p>Antitumor Effect of miR-1294/Pyruvate Kinase M2 Signaling Cascade in Osteosarcoma Cells</p>
... of PKM2 in cancer cells, such as β -catenin, 35 mechanistic target of rapamycin (mTOR), 36 epidermal growth factor receptor (EGFR), 37 and p27 38 pathways. Whether these signaling pathways participate in the ...
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Endothelial Rac1 is essential for hematogenous metastasis to the lung
... A variety of vasoactive stimuli induce endothelial permeability through Rac1, a membrane of Rho small GTPases. Here, we determine whether tumor-secreted vasoactive stimulant through Rac1 inducing permeability contributes ...
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Odorant receptor genes and their expression in migratory Atlantic salmon (Salmo salar, L.)
... (1996) Sensory transduction in vomeronasal neurons: evidence for G alpha o, G alpha 12, and adenylyl cyclase II as major components of a pheromone signaling cascade. A novel[r] ...
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Regulation of enteric neuron migration by the gaseous messenger molecules CO and NO
... (NO/cGMP) signaling cascade, including nitric oxide synthase (NOS) and the target receptor protein soluble guanylyl cyclase (sGC) (Haase and Bicker, ...
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Sucrose Signaling Regulates Anthocyanin Biosynthesis Through a MAPK Cascade in Arabidopsis thaliana
... sugar signaling or/and ...gene cascade integral to the regulation of anthocyanin ...gene cascade module directly targeted the promoter of Transparent Testa 8 ( TT8 ) by direct EIN3 ...the ...
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Mating and Pathogenic Development of the Smut Fungus Ustilago maydis Are Regulated by One Mitogen-Activated Protein Kinase Cascade
... this signaling route is disturbed, pheromone- induced transcription of the a genes is blocked (29, 41), and such strains display filamentous growth that is independent of the b heterodimer (18, ...this ...
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Glucocorticoid dependent Wnt signaling by mature osteoblasts is a key regulator of cranial skeletal development in mice
... Given that MMP14 is a canonical Wnt target gene (Neth et al., 2006; Takahashi et al., 2002) and mature osteoblasts are a dominant source of Wnt proteins (Zhou et al., 2008), we proceeded to investigate the nature of ...
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