simian immunodeficiency virus from chimpanzees
High Prevalence of Simian Immunodeficiency Virus Infection in a Community of Savanna Chimpanzees
... Simian immunodeficiency virus of chimpanzees (SIVcpz) has a significant negative impact on the health, reproduction, and life span of chimpanzees, yet the prevalence and distribution of ...
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Generation of Infectious Molecular Clones of Simian Immunodeficiency Virus from Fecal Consensus Sequences of Wild Chimpanzees
... fragments from fecal virion RNA of a wild-living chimpanzee (Ch-06) in Gombe National Park (46, ...differed from the TAN1 consensus se- quence in 76 ...
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Eastern Chimpanzees, but Not Bonobos, Represent a Simian Immunodeficiency Virus Reservoir
... wild-living chimpanzees in the DRC are at least as high, if not higher, than in Cameroon and Gabon, it seems striking that SIVcpzPts strains have never been found in ...
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Transmission of Simian Immunodeficiency Virus SIVcpz and the Evolution of Infection in the Presence and Absence of Concurrent Human Immunodeficiency Virus Type 1 Infection in Chimpanzees
... undetectable virus loads (below 50 copies/ml plasma), common in HIV-1-in- fected ...intravenously from the naturally infected chronic carrier of SIVcpz-ANT, ...
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Simian Immunodeficiency Virus Infection of Chimpanzees
... arose from cross-species transmission of SIVcpz, where did SIVcpz originate? To answer this question, investigators had to look to the 70 other species of primates inhabiting sub-Saharan Africa, more than half of ...
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Simian Immunodeficiency Virus Infection in Wild-Caught Chimpanzees from Cameroon
... strain from Gabon (GAB2), as well as four SIVcpzPts strains from near Kisangani in the Democratic Re- public of Congo (DRC1) and from Gombe National Park in Tanzania (TAN2, TAN3, and TAN5) (26, 30; ...
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env Sequences of Simian Immunodeficiency Viruses from Chimpanzees in Cameroon Are Strongly Related to Those of Human Immunodeficiency Virus Group N from the Same Geographic Area
... Human immunodeficiency virus type 1 (HIV-1) group N from Cameroon is phylogenetically close, in env, to the simian immunodeficiency virus (SIV) cpz-gab from Gabon and ...
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Amplification of a Complete Simian Immunodeficiency Virus Genome from Fecal RNA of a Wild Chimpanzee
... of simian immunodeficiency virus (SIVcpz) infection of wild chimpanzees (Pan troglodytes) is incomplete since few isolates, mostly from captive apes from Cameroon and Gabon, have ...
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A Pathogenic Threshold of Virus Load Defined in Simian Immunodeficiency Virus- or Simian-Human Immunodeficiency Virus-Infected Macaques
... of virus load will almost certainly be a critical param- eter in the assessment of vaccine efficacy ...with chimpanzees (4, 33) and rhesus macaques (14, 15) suggested that virus load shortly after ...
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Fundamental Difference in the Content of High-Mannose Carbohydrate in the HIV-1 and HIV-2 Lineages
... The virus-encoded envelope proteins of human immunodeficiency virus (HIV) and simian immunode- ficiency virus (SIV) typically contain 26 to 30 sites for N-linked carbohydrate ...
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Neutralization Properties of Simian Immunodeficiency Viruses Infecting Chimpanzees and Gorillas
... in virus titers in chronically HIV-1-infected humans (96, 112), a second anti-CD4 antibody (2D5) afforded only partial protection in rhesus ma- caques challenged with a simian/human immunodeficiency ...
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Simian and Human Immunodeficiency Virus Nef Proteins Use Different Surfaces To Downregulate Class I Major Histocompatibility Complex Antigen Expression
... and simian CV1 cells (panels 4 to 6) were transfected with 10 g of the bicistronic vectors expressing HIV-1 NA7-Nef and a GFP reporter (panels 2 and 5) and SIV 239-Nef and a GFP reporter (panels 3 and 6) or a ...
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Increased Mucosal Transmission but Not Enhanced Pathogenicity of the CCR5-Tropic, Simian AIDS-Inducing Simian/Human Immunodeficiency Virus SHIVSF162P3 Maps to Envelope gp120
... Cells. Human osteosarcoma cells expressing CD4 and either human or rhesus CCR5 (HOS.CD4.CCR5) were gifts from N. Landau (Salk Institute, La Jolla, Calif.) and were maintained in Dulbecco’s modified Eagle’s medium ...
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Vaccine Protection by Live, Attenuated Simian Immunodeficiency Virus in the Absence of High-Titer Antibody Responses and High-Frequency Cellular Immune Responses Measurable in the Periphery
... Vaccine phase. A derivative of SIV239 lacking 100 amino acids that encompass all of the V1-V2 region of gp120 Env is still replication competent but requires point mutations in Env, particularly in gp41, for optimal ...
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Intestinal Epithelial Barrier Disruption through Altered Mucosal MicroRNA Expression in Human Immunodeficiency Virus and Simian Immunodeficiency Virus Infections
... human immunodeficiency virus (HIV) infection has largely been attributed to the rapid and severe depletion of CD4 ⴙ T cells in the gastrointestinal (GI) ...the simian immunodeficiency ...
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Evolution of a Simian Immunodeficiency Virus Pathogen
... derived from isolate SIVmac251 (29), into HuT78 ...necropsy) from macaque F965 was cocultivated with human peripheral blood mononuclear cells (PBMC) for 14 days, followed by passage of cell-free ...
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Differences in the role of the cytoplasmic domain of human parainfluenza virus fusion proteins.
... the simian virus 5 and NDV HN proteins (30, 41) significantly reduced or eliminated surface expression of these ...stomatitis virus G protein reduced or eliminated its transport to the cell surface ...
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Simian foamy virus type 1 is a retrovirus which encodes a transcriptional transactivator.
... Certain oncoviruses, such as human T-lymphotropic virus type 1 HTLV-1, and certain lentiviruses, such as human immunodeficiency virus types 1 and 2 and simian immunodeficiency virus, enc[r] ...
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Complex determinants of macrophage tropism in env of simian immunodeficiency virus.
... Characterization of infectious molecular clones of simian immunodeficiency virus SIVmac and human immunodeficiency virus type 2: persistent infection of rhesus monkeys with molecularly c[r] ...
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Simian immunodeficiency virus mutants resistant to serum neutralization arise during persistent infection of rhesus monkeys.
... Characterization of infectious molecular clones of simian immunodeficiency virus SIV mac and human immunodeficiency virus type 2: persistent infection of rhesus monkeys with molecularly [r] ...
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