single-domain antibody
Single-Domain Antibody-SH3 Fusions for Efficient Neutralization of HIV-1 Nef Functions
... SH3 domain-containing pro- teins, such as the phagocyte-specific kinase ...a single-domain antibody (sdAb) targeting Nef and inhibiting many, but not all, of its biological ...a single ...
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The Antiviral Mechanism of an Influenza A Virus Nucleoprotein Specific Single Domain Antibody Fragment
... IMPORTANCE Influenza virus strains can rapidly escape from protection afforded by seasonal vaccines or acquire resistance to available drugs. Additional ways to interfere with the virus life cycle are therefore urgently ...
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A single-domain antibody-linked Fab bispecific antibody Her2-S-Fab has potent cytotoxicity against Her2-expressing tumor cells
... tandem single-chain variable fragments (scFvs) (Muller and Kontermann 2007; Chames and Baty ...applied single-domain antibody in the construction of bispecific antibodies (Li et ...2015). ...
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Structural basis for the inhibition of HIV 1 Nef by a high affinity binding single domain antibody
... camelid single-domain antibody fragment, termed sdAb19, bound to HIV-1 Nef together with a stabilizing SH3 ...The antibody fragment binds Nef with low nanomolar affinity, which could be ...
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Biotechnological applications of recombinant single-domain antibody fragments
... VH single-domain anti- bodies isolated successively from a semi-synthetic library ...Another single-domain antibody (clone V86) was successfully used in several immunotechniques [27] ...
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Enhanced production of a single domain antibody with an engineered stabilizing extra disulfide bond
... of single domain antibody, and kinetic parameters were calculated using the standard Langmuir binding model available on the ProteOn Manager RM ...
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Retargeting of Adenovirus Vectors through Genetic Fusion of a Single-Chain or Single-Domain Antibody to Capsid Protein IX
... a single-domain antibody (sdAb) identified through panning of a llama sdAb phage library on the non-small-cell lung carcinoma cell line A549 (86), and it was a kind gift of Jianbing Zhang (National ...
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Single domain antibody fragments derived from heavy chain antibodies: a review
... ABSTRACT: Single-domain antibody (sdAb) fragments derived from heavy-chain antibodies of camelids and cartilagi- nous fish represent a new generation of therapeutic agents and ...
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Structure-guided discovery of a single-domain antibody agonist against human apelin receptor
... with antibody-dependent cellular cytotoxicity in vivo, for adult T cell leukemia-lymphoma and peripheral T cell lymphoma ...for antibody discovery is that the receptors have poor thermo- stability and high ...
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Inhibition of synovitis and joint destruction by a new single domain antibody specific for cyclophilin A in two different mouse models of rheumatoid arthritis
... It has been well established that proinflammatory cytokines and MMPs are involved in the pathogenesis of RA [2,3]. CypA may stimulate macrophages to degrade joint cartilage via MMP-9 expression and promote inflammation ...
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Preparation and characterization of a single-domain antibody specific for the porcine epidemic diarrhea virus spike protein
... for antibody library construction. The antibody library size was estimated by calculating the colony forming units (CFU) of 10 serial dilutions of the library on a 2 × YT-AG plate, and the electro-transfor- ...
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Mechanism of Action and Capsid-Stabilizing Properties of VHHs with an In Vitro Antipolioviral Activity
... the antibody can bind to two different viral particles and, in doing so, create a net- work of poliovirus-antibody ...five single-domain antibody fragments tested (PVSP6A, PVSS8A, ...
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Htun van der Horst, Edward (2002): The role of ErbB3/HER3 in gliomas and breast cancer: Molecular mechanisms and potential role as therapeutic target. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... 2001; Sliwkowski et al., 1999). Still, these effects are not sufficient to provide a tumour clearance in living organisms. A recent study by Clynes et al. has shown that the primary effect of Herceptin ® is to stimulate ...
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Samba3 HOWTO pdf
... • At each remote site, to reduce wide-area network traffic and to add stability to remote network operations. The design of the network, and the strategic placement of BDCs, together with an implementation that localizes ...
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Natural and Induced Magnetization in the Bobolink, Dolichonyx Oryzivorus (Aves: Icteridae)
... Because of the manner in which single domain SD and pseudo-single domain PSD magnetite particles attempt to align themselves with the ambient magnetic field, it seems plausible that magn[r] ...
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Rapid quantitative microenzyme linked immunosorbent assay for tetanus antibodies
... Quantitation of the antibody concentration is unique in that multiple serum dilutions are tested on a single patient, the results are plotted as an antibody dilution curve, and the area [r] ...
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Phage displayed domain antibody mimics for pyrethroid and its application in immunoassay
... The ability of the library to bind to anti-PBA MAb was detected by polyclonal ELISA. The polyclonal ELISA result of the fourth round was 5 times higher than that of the original library (Figure 1). Positive clones were ...
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Coupling of PARP1-mediated chromatin structural changes to transcriptional RNA polymerase II elongation and cotranscriptional splicing
... Ser2P antibody, which recog- nizes the transcriptionally engaged, elongating form of RNAPII, we showed that depletion of PARP1 correlated with depletion of this transcriptionally engaged RNAPII at the studied ...
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Dissociable psychosocial profiles of adolescent substance users
... When observing domain contribution to model performance across substances, striking differences are observable. The importance of individual and polysubstance domains across substances contrasts with variation for ...
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The epidermolysis bullosa acquisita antigen (type VII collagen) is present in human colon and patients with crohn's disease have autoantibodies to type VII collagen
... Visser et al (1993) used colon samples from four patients with normal mucosa by colonoscopy, under observation for rectal bleeding. These samples were subjected to direct immuno¯uores- cence using two monoclonal ...
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