single point mutation
Glutamate Excitotoxicity Is Involved in the Induction of Paralysis in Mice after Infection by a Human Coronavirus with a Single Point Mutation in Its Spike Protein
... a single point mutation in the viral spike (S) glycoprotein (Y241H), acquired during viral persistence in human neural cells, led to a hind-limb paralytic disease in infected ...a single ...
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A single point mutation of Ala-25 to Asp in the 14,000-Mr envelope protein of vaccinia virus induces a size change that leads to the small plaque size phenotype of the virus.
... 11 A Single Point Mutation of Ala-25 to Asp in the 14,000Mr Envelope Protein of Vaccinia Virus Induces a Size Change That Leads to the Small Plaque Size Phenotype of the Virus SHIAOCHING[r] ...
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A single point mutation activates the Moloney murine leukemia virus long terminal repeat in embryonal stem cells.
... 9 0022-538X/91/094691-08$02.00/0 Copyright ©D 1991, American Society for Microbiology A Single Point Mutation Activates the Moloney Murine Leukemia Virus Long Terminal Repeat in Embryona[r] ...
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A Single Point Mutation in the Rhinovirus 2B Protein Reduces the Requirement for Phosphatidylinositol 4-Kinase Class III Beta in Viral Replication
... a single point mutation in the conserved 2B protein near the cytosolic carboxy terminus, isoleucine 92 to threonine (termed ...The mutation did not confer resistance to ...
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A single point mutation has pleiotropic effects on pp60v-src function.
... 1898 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest The Rous sarcoma virus mutant tsLA29 encodes a pp6ov-src molecule that is temperature sensitive for both tyrosine k[r] ...
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A single point mutation in cyclin T1 eliminates binding to Hexim1, Cdk9 and RNA but not to AFF4 and enforces repression of HIV transcription
... Figure 6 Illustration of CycT1-V107E on the 3D structures of P-TEFb. a) The V107E mutation in CycT1 was positioned on the structure of P- TEFb and AFF4/SEC. It is located on the H4 helix of the cyclin box (pale ...
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A single point mutation in the VP7 major core protein of bluetongue virus prevents the formation of core-like particles.
... In contrast, similar extension mutants, having 11 extra amino acid residues representing a rabies virus G protein epitope at the amino terminus of VP7, did not prevent CLP formation, alt[r] ...
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Single point mutation in Rabenosyn-5 in a female with intractable seizures and evidence of defective endocytotic trafficking
... Tf associated rapidly and saturably with both PA and CB cells, displaying kinetic constants consistent with binding to the transferrin receptor [13-16], and similar to those previously determined in other mammalian cell ...
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A Single Point Mutation in Nonstructural Protein NS2 of Bovine Viral Diarrhea Virus Results in Temperature-Sensitive Attenuation of Viral Cytopathogenicity
... Y1338H mutation identified in NS2 of ...Y1338H mutation results in a temperature-dependent alteration of the NS2 structure and that the respective struc- tural change modulates the interaction of NS2 with ...
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DIAGNOSTICATION OF MALIGNANT HYPERTHERMIA IN SWINE
... a single point mutation (C→T) in the gene for the skeletal muscle ryanodine receptor ...This mutation generates the production of an abnormal protein (Cys→Arg), which alters the structure and ...
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The Predicted Metal-Binding Region of the Arterivirus Helicase Protein Is Involved in Subgenomic mRNA Synthesis, Genome Replication, and Virion Biogenesis
... a single point mutation in nsp10 (Ser-2429 to Pro; amino acid numbering is based on the full-length ORF1ab protein se- quence) strongly suggested a specific role for this protein in sg mRNA ...
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Mutation of the YXXL Endocytosis Motif in the Cytoplasmic Tail of Pseudorabies Virus gE
... a single point mutation at tyrosine 478 or a double mutation at tyrosine residues 478 and 517 re- sulted in a marked localization of the gE-gI complex to the plasma membrane of infected ...
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Oseltamivir-Resistant Influenza A Viruses Are Transmitted Efficiently among Guinea Pigs by Direct Contact but Not by Aerosol
... NA-E119V mutation has been shown to transmit efficiently by contact, while in the same background an arginine-to-lysine mutation at position 292 (NA-R292K) abolished ...NA-H274Y mutation has also ...
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The genetic drift of human papillomavirus type 16 is a means of reconstructing prehistoric viral spread and the movement of ancient human populations.
... Since the same people were also infected by variants of HPV-18 indistinguishable from East Asian HPV-18 variants or differing by a single point mutation 18, it is certain that the ethnic[r] ...
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Analysis of the stability and affinity of BlaR-CTD protein to β-lactam antibiotics based on docking and mutagenesis studies
... of single point mutation. It might be due to the mutation of hydrophobic AAs to polar AAs, which increased the affinity of the ...The mutation of V197D was also from hydrophobic AA to ...
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Single-Particle Tracking Shows that a Point Mutation in the Carnivore Parvovirus Capsid Switches Binding between Host-Specific Transferrin Receptors
... this mutation is important for the adaptation of CPV to raccoons and possibly other wild carnivore hosts (4, ...used single-particle tracking (SPT) techniques to characterize the binding of raccoon-derived ...
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Widely dispersed p53 mutation in respiratory epithelium A novel mechanism for field carcinogenesis
... a single point mutation in p53 codon 245, a codon which is frequently mutated in lung cancer ...p53 mutation in the tra- cheobronchial tree was verified by repetitive testing at all sites, ...
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Dynamics of Microsatellite Divergence Under Stepwise Mutation and Proportional Slippage/Point Mutation Models
... Figure 1.—PCR model simulation. Probability den- sity of the length in repeat units of a single microsatel- lite after 25,000,000 genera- tions is shown. Initially the microsatellite was a perfect repeat with ...
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Different mutation patterns of atovaquone resistance to Plasmodium falciparum in vitro and in vivo: rapid detection of codon 268 polymorphisms in the cytochrome b as potential in vivo resistance marker
... initial mutation at codon 133 was found to con- fer low resistance, which could be increased by an addi- tional mutation in the domain from codon 272 to codon ...
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Analysis of Single Point Cutting Tool
... There are different materials used for cutting tool such as HSS, cemented carbides, diamond etc. and the various machining parameters associated with the tool are cutting speed, feed and depth of cut. So in order to ...
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