Single-strand break repair
SUMO modification of the neuroprotective protein TDP1 facilitates chromosomal single-strand break repair
... of repair of chromosomal single-strand breaks arising from transcription- associated topoisomerase 1 activity or oxidative ...during single-strand break repair, and ...
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Poly(ADP-Ribose) Polymerase 1 Accelerates Single-Strand Break Repair in Concert with Poly(ADP-Ribose) Glycohydrolase
... 0270-7306/07/$08.00 ⫹0 doi:10.1128/MCB.02248-06 Copyright © 2007, American Society for Microbiology. All Rights Reserved. Poly(ADP-Ribose) Polymerase 1 Accelerates Single-Strand Break Repair ...
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Pathological mutations in PNKP trigger defects in DNA single-strand break repair but not DNA double-strand break repair
... to repair chro- mosomal SSBs induced by IR [this work and ( 54 ...in repair of IR-induced SSBs implicates reduced PNKP-dependent DNA phosphatase activity in the development of ...
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Genetic Requirements for the Single-Strand Annealing Pathway of Double-Strand Break Repair in Saccharomyces cerevisiae
... A densitometric analysis of these data showed that in the wild-type strain (Figure 5a) the whole recombina- tion product (deletion plus gene conversion) repre- sented alm[r] ...
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Drosophila ATR in Double-Strand Break Repair
... detect repair defects in grp or lok single ...HR repair of DSBs generated by P-element excision in different tissues, throughout ...39-ended single-strand overhang (B eall and R io ...
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MTE1 Functions with MPH1 in Double-Strand Break Repair
... Increased phleomycin-induced DSBs in the absence of MTE1 The presence of Mte1 at an induced DSB, and the sensitivity of mte1D strains to DSBs, suggested that Mte1 could play a role in DSB repair. We measured Rad52 ...
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Investigating double-strand break formation and repair in meiosis
... Two proteins have been implicated in the negative regulation of DSB formation in meiosis; the serine/threonine kinases Tel1 ATM and Mec1 ATR . Both proteins are involved in trans inhibition, a process that prevents DSBs ...
272
Single-Strand Annealing Plays a Major Role in Double-Strand DNA Break Repair following CRISPR-Cas9 Cleavage in Leishmania
... DNA polymerase is the key player in MMEJ in mammalian cells. The polymerase domain located at the C terminus of Pol is required in MMEJ for annealing the 3= overhangs and filling the gaps between broken DNA ends. The ...
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The Effect of Gap Length on Double-Strand Break Repair in Drosophila
... a repair frequency that differed signifi- cantly from any of the others in this group when comparisons were made using permutation tests with the single-male ...of repair opportunities to successful ...
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Double-Strand Break Repair by Non-homologous End-Joining
... a single DSB in one of two direct chromosomal repeats in hamster cells (Liang et ...the repair products, in brief, found that SSA accounted for -30% of the repair events, whilst 14% of the products ...
265
Differential Effects of DNA Double-Strand Break Repair Pathways on Single-Strand and Self-Complementary Adeno-Associated Virus Vector Genomes
... DNA repair and recombination pathways upon release into the host nucleus, resulting in circu- larization, concatemer formation, or chromosomal ...of single-strand rAAV (ssAAV) and self-complementary ...
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A Genetic Screen For DNA Double-Strand Break Repair Mutations in Drosophila
... double-strand break (DSB) repair has been greatly facilitated by the use of rare- cutting endonucleases, which induce a break precisely at their cut sites that can be strategically placed in ...
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Functional Analysis of Maize RAD51 in Meiosis and Double-Strand Break Repair
... Meiotic homologous pairing is reduced in the rad51 double mutants: Even though chromosome pairing at pachytene in rad51 double mutants looks indistin- guishable from wild-type plants at the light microscope level (Figure ...
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Differential Usage of Alternative Pathways of Double-Strand Break Repair in Drosophila
... conversion repair, the frequency of mitotic crossing over in the germ line indicates the relative prevalence of repair by double Holliday junction (DHJ) formation ...synthesis-dependent strand ...
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Meiotic Double-Strand Break Proteins Influence Repair Pathway Utilization
... long single-stranded overhangs are bound by Rad51 and Dmc1 proteins, which drive strand invasion and the search for extended sequence ...this strand-exchange activity relies on RAD-51, the only RecA ...
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Meiotic Double-Strand Break Proteins Influence Repair Pathway Utilization
... long single-stranded overhangs are bound by Rad51 and Dmc1 proteins which drive strand invasion and the search for extended sequence ...this strand- exchange activity relies on RAD-51, the only RecA ...
39
Assays for DNA double-strand break repair by microhomology-based end-joining repair mechanisms.
... enable repair by ...the break site, the SD- MMEJ mechanism often amplifies alternate microhomol- ogous sequences, as needed for pairing with a compatible single stranded sequence on the other DNA ...
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Suppression of the Double-Strand-Break-Repair Defect of the Saccharomyces cerevisiae rad57 Mutant
... lesion repair or bypass. Single- stranded gaps that form on the lagging strand or following restart of the leading strand downstream of the lesion are bypassed by template switching, homol- ...
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Coordination of DNA Ends During Double-Strand-Break Repair in Bacteriophage T4
... total repair probability of a cell containing that number of BAS1 ...rII single ent numbers of BAS1 ...rII single mutant the predicted rII single mutant to rII ⫹ recombinant ratio to rII ⫹ ...
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Double-Strand Break Repair in Tandem Repeats During Bacteriophage T4 Infection
... Recombinational repair of double-strand breaks in tandemly repeated sequences often results in the loss of one or more copies of the ...The single-strand annealing (SSA) model for ...
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