Sirtuin 1(Sirt1)
Resveratrol Restores Sirtuin 1 (SIRT1) Activity and Pyruvate Dehydrogenase Kinase 1 (PDK1) Expression after Hemorrhagic Injury in a Rat Model
... of sirtuin 1 (SIRT1) as a potential target in ...of SIRT1) after T-H improved left ventricular function and tissue ATP ...on SIRT1 activity. In this study, we evaluated the activity of ...
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Regulation of histone H2A.Z expression is mediated by sirtuin 1 in prostate cancer
... that sirtuin 1 is responsible for acquisition of genetic mutations in BCR-ABL in chronic myelogenous leukemia cells, conferring resistance to imatinib mesylate, which inhibits that tyrosine kinase [30, ...
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Celecoxib and sulindac inhibit TGF-β1-induced epithelial- mesenchymal transition and suppress lung cancer migration and invasion via downregulation of sirtuin 1
... that SIRT1 is a pivotal positive regulator of TGF-β-induced EMT and lung cancer migration, and invasion by ...of sirtuin 1 (SIRT1) deletion on transforming growth factor (TGF)-β1-induced A549 ...
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Repositioning antipsychotic chlorpromazine for treating colorectal cancer by inhibiting sirtuin 1
... by sirtuin 1 (SIRT1), a class III histone ...down SIRT1 sensitized tumor cells to CPZ ...of SIRT1 protein participating downstream of JNK, and JNK suppression abrogated CPZ-mediated ...
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The effects of green cardamom on blood glucose indices, lipids, inflammatory factors, paraxonase 1, sirtuin 1, and irisin in patients with nonalcoholic fatty liver disease and obesity: study protocol for a randomized controlled trial
... Background: The relationship between dietary components and nonalcoholic fatty liver disease (NAFLD) needs to be further investigated. The potential health benefits of cardamom have been found in some studies. Cardamom ...
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Original Article Decreased circulating levels of sirtuin-1 in patients with aortic dissection
... Abstract: Sirtuin-1 (SIRT1) has long been associated with beneficial metabolic effects and vascular ...endogenous SIRT1 in patients with aortic dissection (AD) has not been fully ...serum ...
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Sirtuin 1 stimulates the proliferation and the expression of glycolysis genes in pancreatic neoplastic lesions
... of Sirt1 is flanked by loxP sites to obtain homozygous Sirt1-deficient KC mice (KC;Sirt1-lox) [14, ...of SIRT1 protein is found in the pancreas of the KC;Sirt1-lox animals (Figure 1A ...
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Effects of cinnamon supplementation on expression of systemic inflammation factors, NF-kB and Sirtuin-1 (SIRT1) in type 2 diabetes: a randomized, double blind, and controlled clinical trial
... (P = 0.02). In addition, it is interesting to be mentioned that although the mean level of NF-kB had no significant within group changes in the treatment and placebo groups, the placebo group revealed a trend towards ...
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Sirtuin 1: A Target for Kidney Diseases
... of SIRT1 on (a) suppression of apoptosis, inflam- mation and fibrosis; (b) induction of autophagy and EPO expression; and (c) regulation of lipid metabolism, glu- cose homeostasis and blood pressure (Figure ...
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Green cardamom increases Sirtuin-1 and reduces inflammation in overweight or obese patients with non-alcoholic fatty liver disease: a double-blind randomized placebo-controlled clinical trial
... serum Sirt1, tumor necrosis factor-alpha (TNF- α ), high sensitive c-reactive protein (hs-CRP), interleukin-6 (IL-6), alanine transaminase (ALT), and aspartate transaminase (AST) were ...increased Sirt1 and ...
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Original Article Bioinformatics analysis of gene expression profiles in chronic lymphocytic leukemia
... Member 1), TP53 (Tumor Protein P53) with higher degrees were significantly enriched in PPI network for up-reg- ulated genes, and UBE2I (Ubiquitin-Conjugating Enzyme E2I), CBLB (Cbl Proto-Oncogene B, E3 Ubiquitin ...
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Original Article Ganoderma lucidum polysaccharides improve renal aging through upregulating SIRT1 expression
... homeobox 1 (Zeb1), P16, P21, and sirtuin 1 (SIRT1) were explored in renal tissues of senescence-accelerated-resistant (SAMR1) mice and (senescence-accelerated prone mouse) ...of SIRT1 ...
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The anti-ageing molecule sirt1 mediates beneficial effects of cardiac rehabilitation
... EX-527: Sirtuin 1 inhibitor; ACCF: American College of Cardiology Foundation; AHA: American Heart Association; ARBs: Angiotensin II Receptor Blockers; ATZ: 3-amino-1,2,4-triazole; AU: Arbitrary unit; BMI: ...
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An Updated Review On Anticancer Activity Of Capsaicin
... of sirtuin 1 (SIRT1) deacetylase, possibly through proteasome-mediated protein ...of SIRT1, which in turn, enhanced acetylation of cortactin and ...
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Microglial CX3CR1 promotes adult neurogenesis by inhibiting Sirt 1/p65 signaling independent of CX3CL1
... microglial SIRT1 increases proliferation of DCX + cells in cx3cr1 −/− mice and improves spatial learning and ...A sirtuin 1 activity assay using nuclear extracts from sorted microglia revealed ...
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Sirtuins and Chronic Obstructive Pulmonary Disease
... DOI: 10.4236/fns.2018.910089 1260 Food and Nutrition Sciences [35] Ichikawa, T., Hayashi, R., Suzuki, K., Imanishi, S., Kambara, K., Okazawa, S., In- omata, M., Yamada, T., Yamazaki, Y., Koshimizu, Y., Miwa, T., Matsui, ...
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SIRT1 Suppresses Human T-Cell Leukemia Virus Type 1 Transcription
... type 1 (HTLV-1)-associated diseases are poorly treatable, and HTLV-1 vaccines are not ...when SIRT1 was overexpressed, but Tax activa- tion of NF- B was ...when SIRT1 was ...a ...
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SIRT1-modified human umbilical cord mesenchymal stem cells ameliorate experimental peritoneal fibrosis by inhibiting the TGF-β/Smad3 pathway
... injected 1 × 10 7 hUCMSCs, another group of rats were intravenously injected 1 × 10 7 SIRT1-modified hUCMSCs, and PBS was injected into the third group as positive control of periton- eal ...
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The sirtuins in the pathogenesis of cancer
... 2005), SIRT1 and SIRT6 have been reported to exert both ADP ribosyltransferase and substrate-specific deacetylase activities (Michishita et ...2000). Sirtuin enzymatic activities have been linked to a ...
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Sirtuin Lipoamidase Activity Is Conserved in Bacteria as a Regulator of Metabolic Enzyme Complexes
... CobB interacts with lipoylated metabolic complexes in vivo. To further establish that CobB can associate with these substrates in vivo, we performed an immunoaffinity purification (IP) experiment, in which His-CobB was ...
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